Systematic review of Ethiopian medicinal plants used for their anti-inflammatory and wound healing activities

Nigussie, Dereje; Makonnen, Eyasu; Tufa, Takele Beyene; Brewster, Malcolm; Legesse, Belete Adefris; Fekadu, Abebaw; Davey, Gail

doi:10.1016/j.jep.2021.114179

Cited by 23 publications

(14 citation statements)

References 70 publications

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“…The ethnomedicinal utilization of the species is recorded in many previous works. Coffea arabica (AbouZid and Mohamed, 2011), Nigella sativa (Tiwari et al, 2004;AbouZid and Mohamed, 2011;Mandaville, 2011;Abouri et al, 2012;Islam et al, 2020) and Zingiber officinale (Davison & Frank, 1935;Tiwari et al, 2004;AbouZid and Mohamed, 2011;Abouri et al, 2012;Islam et al, 2020;Nigussie et al,, 2021;Aparicio et al, 2021). In addition to the cultivated Lawsonia inermis (Mandaville, 2011;Islam et al, 2020;Nigussie et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…Coffea arabica (AbouZid and Mohamed, 2011), Nigella sativa (Tiwari et al, 2004;AbouZid and Mohamed, 2011;Mandaville, 2011;Abouri et al, 2012;Islam et al, 2020) and Zingiber officinale (Davison & Frank, 1935;Tiwari et al, 2004;AbouZid and Mohamed, 2011;Abouri et al, 2012;Islam et al, 2020;Nigussie et al,, 2021;Aparicio et al, 2021). In addition to the cultivated Lawsonia inermis (Mandaville, 2011;Islam et al, 2020;Nigussie et al, 2021). The other three species that are wild include Acacia nilotica that is scattered open vegetation in the main channel of wadis as indicated by Boulos (2008).…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have been carried out to deal with the ethnobotanical utilization of plant species ( Ribeiro et al, 2010;Mandaville, 2011;Khajoei Nasab and Khosravi, 2014;Manas et al, 2015;Maleki and Akhani, 2018;Rana et al, 2019;Aly, 2019;Salmerón-Manzano et al, 2020;Aparicio et al, 2021;Khajuria et al, 2021;Nigussie et al, 2021). Goodman and Hobbs (1988) made vital findings as a naturalist and described plants in detail by a particular tribe in the area of study.…”

Section: Introductionmentioning

confidence: 99%

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Ethnobotanical survey among the Nubian and south eastern tribes of Egypt

Soliman

Hamdy

Hamada

2021

Catrina: The International Journal of Environmental Sciences

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This survey was undertaken on four tribes (Ababda, Bisharia, Nubian, and Rashayda) living in Egypt's southern Nile Valley and Eastern Desert to chronicle and evaluate traditional herbal treatments, as well as to examine the links between these tribes based on ethnobotanical use. A total of 180 interviews with Bedouins and herbal healers were undertaken, with 45 informants for each tribe, ranging in age from 18 to 85 years. There were 39 species in total, belonging to 36 genera and 27 families. Fabaceae and Poaceae and Rutaceae were the species-rich families. The used wild species comprised 43.6%, cultivated species (38.5%) and the remaining 17.9% were bought from the herbalist shops. The leaves were the most commonly used part (31%), followed by stems and fruits (22% each). Distinct species included Acacia nilotica, that is used in the treatment of dental discomfort and has a use-value of 33.3 %, and Cymbopogon schoenanthus subsp. proximus, that is used in the treatment of cough and headache and has a use-value of 35% and 30.6%, respectively. A combination of Acacia nilotica and Lawsonia inermis, has a use-value of 22.2 % for the treatment of sore throats. Based on ethnobotanical treatments, the most resemblance was found between the Nubian and Rashayda tribes (55.3%), that the Rashayda' nomads utilized the Nubian markets for the winter, and Nubians were supplied with livestock or handicrafts by the nomads, followed by 46.8% between Ababda and Bisharia that both tribes are shared land, resources, and even reached a historical homogeneous state not only due to land proximity but also through marriage and social relations. The most prevalent ailments were diarrhoea and headache, each had seven different recipes, while cough and dental aches had six. This type of research should be encouraged in order to better understand how the common flora might be used in human healthcare.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ethnobotanical survey among the Nubian and south eastern tribes of Egypt

Soliman

Hamdy

Hamada

2021

Catrina: The International Journal of Environmental Sciences

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“…Using plants with medicinal properties to treat wounds have been found useful in fighting against infection and accelerate wound healing ( 75 ). A recent study conducted by Nigussie et al, described Lawsonia inermis and Azadirachta indica were the most studied plant species for wound healing, and the most common in vivo techniques used for the anti-inflammatory and the wound healing assays were carrageenan-induced paw edema, and excision and incision wound models, respectively ( 76 ). CAM is not only used for treating non-oncologic cutaneous problems but is also used in the prevention and treatment of malignant diseases ( 77 ).…”

Section: Role Of Complementary and Alternative Medicines In Wound Treatmentmentioning

confidence: 99%

Challenges in Healing Wound: Role of Complementary and Alternative Medicine

et al. 2022

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“…[31][32][33] Research conducted in recent years shows that extracts of many traditional medicinal plants have inhibitory and sometimes completely lethal effects on various microorganisms. 34 Among the plants used for therapeutic and medicinal purposes, trachyspermum and nettle plants received more attention. Trachyspermum, scientifically known as L. copticum Carum, belongs to the Apiaceae family.…”

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confidence: 99%

PVA based nanofiber containing cellulose modified with graphitic carbon nitride/nettles/trachyspermum accelerates wound healing

Nemati

Ashjari

Rashedi

et al. 2021

Biotechnology Progress

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Today, bacterial cellulose has received a great deal of attention for its medical applications due to its unique structural properties such as high porosity, good fluid uptake, good strength, and biocompatibility. This study aimed to fabricate and study bacterial cellulose/graphitic carbon nitride/nettles/trachyspermum nanocomposite by immersion and PVA/BC/g-C 3 N 4 /nettles/trachyspermum nanofiber by electrospinning method as a wound dressing. The g-C 3 N 4 and g-C 3 N 4 solution were synthesized and then were characterized using Fourier transform infrared, X-ray diffraction, Zeta Potential, and scanning electronic microscope analyzes. Also, the antibacterial properties of the synthesized materials were proved by gram-positive and gram-negative bacteria using the minimum inhibitory concentration method.Besides, the toxicity, migration, and cell proliferation results of the synthesized materials on NIH 3T3 fibroblasts were evaluated using MTT and scratch assays and showed that the BC/PVA/g-C 3 N 4 /nettles/trachyspermum composite not only had no toxic effect on cells but also contributed to cell survival, cell migration, and proliferation has done. To evaluate the mechanical properties, a tensile strength test was performed on PVA/BC/g-C 3 N 4 /nettles/trachyspermum nanofibers, and the results showed good strength of the nanocomposite. In addition, in vivo assay, the produced nanofibers were used to evaluate wound healing, and the results showed that these nanofibers were able to accelerate the wound healing process so that after 14 days, the wound healing percentage showed 95%. Therefore, this study shows that PVA/BC/g-C 3 N 4 /nettles/trachyspermum nanofibers effectively inhibit bacterial growth and accelerate wound healing.

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Systematic review of Ethiopian medicinal plants used for their anti-inflammatory and wound healing activities

Cited by 23 publications

References 70 publications

Ethnobotanical survey among the Nubian and south eastern tribes of Egypt

Ethnobotanical survey among the Nubian and south eastern tribes of Egypt

Challenges in Healing Wound: Role of Complementary and Alternative Medicine

PVA based nanofiber containing cellulose modified with graphitic carbon nitride/nettles/trachyspermum accelerates wound healing

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