Systematic review of cardiovascular disease and cardiovascular death in patients with a small abdominal aortic aneurysm

Bath, Michael; Gokani, V.J.; Sidloff, David; Jones, Louise; Choke, Edward; Sayers, Robert D.; Bown, Matthew J.

doi:10.1002/bjs.9837

Cited by 80 publications

(60 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, CV-events, and not AAA rupture, are by far the commonest cause of death in patients with small AAA (<55mm in maximal diameter), regardless of whether they are offered an intervention to treat the aneurysm or not (5) -in the MASS screening trial 41% of deaths in the screening arm were due to a CV cause, of which only 2% were AAA related (2). A recent meta-analysis using data from 10 old retrospective series of patients with a small AAA which had previously reported CV-death rates, showed a 3% per year chance of CV-mortality, as well as a high prevalence (41%) of ischaemic heart disease (IHD) in this population (6). This risk of CV death is similar to patients that have already experienced a major cardiac event.…”

Section: Introductionmentioning

confidence: 76%

Patients with Small Abdominal Aortic Aneurysm are at Significant Risk of Cardiovascular Events and this Risk is not Addressed Sufficiently

Bath

Saratzis

Saedon

et al. 2017

European Journal of Vascular and Endovascular Surgery

View full text Add to dashboard Cite

Previous data suggest that patients with small AAA have a high risk of cardiovascular (CV) mortality and morbidity. The recent implementation of the NHS AAA screening programme (NAAASP) and similar programmes elsewhere has led to several individuals being diagnosed with small AAA, yet addressing their CV risk-factors is still not formalised clinical practice within screening programmes. The precise contemporary CV risk-profiles of these patients also remain unknown. Our findings suggest that despite recent advances in CV prevention in highrisk populations, the management of patients with small AAA remains suboptimal. Better CVprotection should be offered and monitored during surveillance. ABSTRACTBackground: Patients with abdominal aortic aneurysm (AAA) are at significant-risk of

show abstract

Section: Introductionmentioning

confidence: 76%

Patients with Small Abdominal Aortic Aneurysm are at Significant Risk of Cardiovascular Events and this Risk is not Addressed Sufficiently

Bath

Saratzis

Saedon

et al. 2017

European Journal of Vascular and Endovascular Surgery

View full text Add to dashboard Cite

show abstract

“…This observation was also seen in MASS, where men with an AAA had lower physical QoL scores, from both the Short Form 36 (QualityMetric, Lincoln, Rhode Island, USA) and EuroQol – 5D (EuroQol Group, Rotterdam, The Netherlands) questionnaires. AAA is an independent marker of cardiovascular risk, with a documented 3·0 per cent per year risk of cardiovascular death in patients with a small AAA. AAA and cardiovascular disease have been shown to share risk factors.…”

Section: Discussionmentioning

confidence: 99%

Impact of abdominal aortic aneurysm screening on quality of life

Bath

Sidloff

Saratzis

et al. 2018

British Journal of Surgery

Self Cite

View full text Add to dashboard Cite

BackgroundScreening for abdominal aortic aneurysm (AAA) is known to reduce AAA‐related mortality; however, the psychological impact of population AAA screening is unclear. The aim was to assess the impact of AAA diagnosis on quality of life (QoL) using data from an established AAA screening programme.MethodsMental and physical QoL scores for men diagnosed with AAA through participation in the English and Welsh AAA screening programmes were compared with no‐AAA controls. Participants were identified through the United Kingdom Aneurysm Growth Study (UKAGS), a nationwide prospective cohort study of men with an AAA of less than 55 mm diagnosed through voluntary participation in screening. The UKAGS participants completed QoL questionnaires at the time of screening and annually thereafter.ResultsA transient reduction in mental QoL scores was observed following the diagnosis of AAA, returning to baseline levels after 12 months. Physical QoL remained consistently lower in the AAA cohort. Participants thought about their AAA and the AAA growth progressively less 12 months after the initial screening diagnosis. AAA growth rate had no influence over QoL parameters.DiscussionThis study suggests that screening for AAA does reduce mental QoL; however, this effect is transient (less than 12 months). Men diagnosed with AAA have a consistently worse physical QoL compared with controls.

show abstract

“…Importantly, an AAA is in itself a marker for other cardiovascular diseases. Patients with small AAA have a high prevalence of ischaemic heart disease, myocardial infarction, heart failure, and stroke, as well as a 3 % yearly risk for cardiovascular death [27]. Therefore, if high biomarker levels could be demonstrated in patients with AAA, other cardiovascular processes may likely be the explanation.…”

Section: Discussionmentioning

confidence: 99%

No relation between biomarkers at age 47–49 and aortic diameter after 14–19 years of follow-up – a population-based study

Taimour

Zarrouk

Holst

et al. 2017

Vasa

View full text Add to dashboard Cite

Summary:Background: Biomarkers refl ecting diverse pathophysiological pathways may play an important role in the pathogenesis of abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA), levels of many biomarkers are elevated and correlated to aortic diameter among 65-year-old men undergoing ultrasound (US) screening for AAA. Probands and methods: To evaluate potential relationships between biomarkers and aortic dilatation after long-term follow-up, levels of C-reactive protein (CRP), proneurotensin (PNT), copeptin (CPT), lipoprotein-associated phospholipase 2 (Lp-PLA2), cystatin C (Cyst C), midregional proatrial natriuretic peptide (MR-proANP), and midregional proadrenomedullin (MR-proADM) were measured in 117 subjects (114 [97 %] men) aged 47-49 in a prospective population-based cohort study, and related to aortic diameter at US examination of the aorta after 14-19 years of follow-up.

show abstract

Systematic review of cardiovascular disease and cardiovascular death in patients with a small abdominal aortic aneurysm

Cited by 80 publications

References 48 publications

Patients with Small Abdominal Aortic Aneurysm are at Significant Risk of Cardiovascular Events and this Risk is not Addressed Sufficiently

Patients with Small Abdominal Aortic Aneurysm are at Significant Risk of Cardiovascular Events and this Risk is not Addressed Sufficiently

Impact of abdominal aortic aneurysm screening on quality of life

No relation between biomarkers at age 47–49 and aortic diameter after 14–19 years of follow-up – a population-based study

Contact Info

Product

Resources

About