Systematic review of carcinoma arising in pharyngeal diverticula: A 112-year analysis

Abstract

Irregular symptoms in benign diverticula should raise suspicion of malignancy. Management consists of surgical excision ± PORT. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1368-1375, 2014.

Coincidental Killian-Jamieson Diverticulum During Thyroid Surgery: A Rare Cause of Dysphagia

“…Carcinoma of the pharyngeal diverticula has an incidence of 0.3-8% in literature (9). Therefore, careful histopathological examination is necessary to diagnose the malignancy.…”

“…Therefore, careful histopathological examination is necessary to diagnose the malignancy. Further computerized tomography scan and magnetic resonance imaging should be performed for the planning of treatment (9).…”

TP53 and PTEN as driver mutations in Zenker's carcinoma—a clinical presentation

“…sarcomas, inflammatory pseudotumor, and lipoma) of the hypopharynx and proximal esophagus. 8,9 Squamous cell carcinoma arising in Zenker's diverticulum is a rarity with an incidence of 0.3%-1.5% of benign diverticula 5,6 with a potentially poor prognosis of 3-year survival of 39% and 5-year survival of 14%. 5 The most comprehensive systematic review published by Khan et al in 2014 highlights many specific clinical features of Zenker's carcinoma compared to benign pharyngeal diverticula.…”

“…The two main treatment options for Zenker's diverticulum include transcervical excision and an endoscopic approach (rigid or flexible), which may be a good alternative in select patient groups 4 . The annual incidence of pharyngeal diverticulum worldwide is approximately 2 per 100 000, occurring after the fifth decade of life, displaying typical symptoms of dysphagia, regurgitation of undigested food, aspiration, foetor ex ore, and weight loss 5‐7 . Lump in the neck, bloody sputum, and a sudden worsening of dysphagia seem to occur more frequently in Zenker's carcinoma 6 .…”

“…The annual incidence of pharyngeal diverticulum worldwide is approximately 2 per 100 000, occurring after the fifth decade of life, displaying typical symptoms of dysphagia, regurgitation of undigested food, aspiration, foetor ex ore, and weight loss 5‐7 . Lump in the neck, bloody sputum, and a sudden worsening of dysphagia seem to occur more frequently in Zenker's carcinoma 6 . As symptoms are not specific, malignancy in patients presenting these conditions should always be ruled out.…”