Systematic Review: Neutrophils and Clinical Outcomes in Patients With Acute Coronary Syndromes and/or Cardiac Revascularization

Guasti, Luigina; Dentali, Francesco; Castiglioni, Luana; Maroni, Lorenzo; Marino, Franca; Squizzato, Alessandro; Ageno, Walter; Gaudio, Giovanni; Grandi, Andrea; Cosentino, Marco; Contini, Sara; Macchi, Valentina; Serratiʼ, M.; Interlandi, G; Venco, Achille

doi:10.1097/00004872-201106001-01610

Cited by 17 publications

(27 citation statements)

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“…Although endothelial damage has been known as the triggering factor for the formation of atherosclerotic plagues, inflammatory process is responsible in the initiation and progression of the atherosclerosis [3]. Inflammatory markers, including white blood cell (WBC), C-reactive protein (CRP), and homocysteine, have been used for the prediction of cardiovascular events in asymptomatic patients [5]. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have recently been investigated as new predictors for worse cardiovascular outcome [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have recently been investigated as new predictors for worse cardiovascular outcome [6,7]. Previous studies have shown that NLR is associated with morbidity and mortality in many cardiovascular diseases such as hypertension, heart failure, infective endocarditis, and acute coronary syndromes (ACS) [5][6][7][8]. Although previous data have shown that NLR is associated with severity of CAD [4], its relation with PLR remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Relation of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio with coronary artery disease severity in patients undergoing coronary angiography

et al. 2015

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A b s t r a c tBackground: Atherosclerosis is a chronic systemic inflammatory disease. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are systemic inflammatory markers that are correlated with poor cardiovascular outcomes. Aim:To explore the relation of NLR and PLR with severity of coronary artery disease (CAD). Methods:The study population consisted of 180 consecutive patients who underwent elective coronary angiography (CAG). While 100 patients (22 female, mean age: 60.6 ± 12.6 years) had abnormal CAG, 80 patients (44 female, mean age: 57.2 ± 10.9 years) had normal CAG. NLR and PLR were calculated as the ratio of neutrophil count to lymphocyte count and as the ratio of platelet count to lymphocyte count, respectively. Results:Although age distribution was similar between the two groups (p = 0.073), female gender was significantly higher in the normal CAG group (p < 0.001). Patients with abnormal CAG had significantly higher NLR and PLR when compared to patients with normal CAG (3.7 ± 2.6 vs. 2.2 ± 1.7, p < 0.001 and 125.9 ± 72.3 vs. 102.6 ± 33.8, p = 0.027, respectively). NLR and PLR were significantly correlated with SYNTAX score and GENSINI score. In logistic regression analyses, only NLR (odds ratio: 1.576, confidence interval: 1.198-2.072, p = 0.001) was an independent predictor of CAD. An NLR of 2.3 or higher predicted the CAD with a sensitivity of 66% and specificity of 70%.Conclusions: NLR and PLR seem to be a simple method to predict severity of CAD in patients undergoing elective CAG, and it may be part of cardiovascular examination before CAG.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relation of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio with coronary artery disease severity in patients undergoing coronary angiography

et al. 2015

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“…As a representative indicator of inflammation in the body, the neutrophil-to-lymphocyte ratio (NLR) has been newly used as a biological sign to predict coronary heart disease (Gibson et al, 2010). A series of studies show that a high NLR is an independent risk factor for the progression of atheromatous plaque lesions, in-stent restenosis, cardiac death after percutaneous coronary intervention or coronary artery bypass surgery, and development of cardiac events in acute coronary syndrome (ACS) (Gibson et al, 2007;Muhmmed Suliman et al, 2010;Guasti et al, 2011;Kalay et al, 2012;Turak et al, 2012). The relation between NLR and CAD has been shown in several studies; however, most of these studies focus on the significance of this relation in diagnosing ACS or predicting the outcome instead of the severity of coronary stenosis.…”

Section: Introductionmentioning

confidence: 99%

Relation between neutrophil-to-lymphocyte ratio and severity of coronary artery stenosis

Zhang¹,

Chen²,

Yu³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. This study aimed to investigate the relation between the neutrophil-to-lymphocyte ratio (NLR) and the severity of coronary artery stenosis. A total of 219 patients were included in the study, comprising 51 coronary artery atherosclerosis (CAC) patients, 92 stable angina pectoris (SAP) patients, and 76 acute coronary syndrome (ACS) patients. Based on the results of coronary angiography, all patients were divided into two groups according to the Gensini scores: the low-score group (N = 142) and the high-score group (N = 77). The NLR was computed from the ratio of neutrophils and lymphocytes from the complete blood count. The association between the NLR and severity of coronary artery disease was assessed using correlation analysis and logistic regression. The NLR was higher in ACS patients than in SAP and CAC patients (P < 0.05). In addition, the NLR was higher in the high-score group than in the low-score group (P < 0.05). Correlation analysis showed that the NLR was significantly correlated with the Gensini score. After multivariate analysis, high NLRs were independent predictors of high Gensini scores, together with age and high-density lipoprotein. A cutoff NLR of 2.385 predicted high Gensini scores with a sensitivity and specificity of 64 and 63%, respectively. The study suggests that the NLR is an independent Neutrophil-to-lymphocyte ratio and coronary artery stenosis predictor of coronary heart disease that may be useful for predicting the severity of coronary artery stenosis.

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“…Neutrophils are classically considered as short-lived phagocytes with the ability to release vast amounts of proteolytic enzymes and reactive oxygen species, both of which are important during bacterial infections. Thus, both exuberant and/or diminished responses by the innate immune system may worsen clinical outcomes in severely ill patients with acute and chronic liver diseases [16], airway diseases [17] or acute coronary syndrome [18]. Neutrophils play key roles in sepsis [19] and atherosclerosis [20] and were shown to aggravate endothelial dysfunction, to activate macrophages, promote foam cell formation and to contribute to weakening of the fibrous cap [20].…”

Section: Introductionmentioning

confidence: 99%

Neutrophil effector responses are suppressed by secretory phospholipase A2 modified HDL

2015

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Systematic Review: Neutrophils and Clinical Outcomes in Patients With Acute Coronary Syndromes and/or Cardiac Revascularization

Cited by 17 publications

References 0 publications

Relation of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio with coronary artery disease severity in patients undergoing coronary angiography

Relation of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio with coronary artery disease severity in patients undergoing coronary angiography

Relation between neutrophil-to-lymphocyte ratio and severity of coronary artery stenosis

Neutrophil effector responses are suppressed by secretory phospholipase A2 modified HDL

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