2014
DOI: 10.5114/aoms.2014.44855
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Systematic review/Meta-analysis Clinical outcomes of second- versus first-generation drug-eluting stents in patients with acute myocardial infarction: a meta-analysis of randomized controlled trials

Abstract: IntroductionIt remains unclear whether the clinical outcomes of patients with acute myocardial infarction (AMI) receiving second- and first-generation drug-eluting stents (DES) are identical. The study aimed to investigate the differences in clinical utility between the two generations of DES in these specific subjects by a meta-analysis.Material and methodsWe systemically searched PubMed and EMBASE databases and the Cochrane Library up until January 2013. Randomized trials, which compared clinical outcomes of… Show more

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Cited by 10 publications
(7 citation statements)
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References 27 publications
(33 reference statements)
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“…Studies have confirmed that second-generation DES is more beneficial than first-generation DES 3 5 as it reduced the late ST risk. Therefore, it is reasonable to shorten the DAPT duration after second-generation DES implantation.…”
Section: Introductionmentioning
confidence: 95%
“…Studies have confirmed that second-generation DES is more beneficial than first-generation DES 3 5 as it reduced the late ST risk. Therefore, it is reasonable to shorten the DAPT duration after second-generation DES implantation.…”
Section: Introductionmentioning
confidence: 95%
“…Therefore, every effort is being made to improve not only therapy but also risk stratification. Novel parameters helpful in the assessment of prognosis are continuously searched for [3133]. High-risk patients require more intensive ambulatory monitoring and more aggressive treatment.…”
Section: Discussionmentioning
confidence: 99%
“…[ 25 26 27 ] Some studies even demonstrated remarkably lower long-term mortality with second-generation DES as compared with first-generation DES. [ 28 29 30 ] Presently, second-generation DES were widely applied in patients with CAD undergoing PCI in clinical practice. With the exception of the EXCEL study,[ 23 ] all other previous studies[ 21 22 24 ] have enrolled patients entirely or mostly treated with first-generation DES.…”
Section: Discussionmentioning
confidence: 99%