Systematic review, meta-analysis and regression of randomised controlled trials reporting an association between an intake of circa 25g soya protein per day and blood cholesterol

Harland, Janice I.; Haffner, Tanya A.

doi:10.1016/j.atherosclerosis.2008.04.006

Cited by 138 publications

(105 citation statements)

References 53 publications

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“…Increased consumption of grain legumes as well as consumption of targeted functional foods and dietary supplements (or nutraceuticals) based on legumes could help in realizing their positive health effects (Sirtori et al 2009). Soybean and lupin proteins have the potential to reduce blood cholesterol and thus protect from hypercholesterolemia and atherosclerosis (Harland and Haffner 2008;Marchesi et al 2008;Sirtori et al 2012). In addition, lupin proteins are considered to have an antidiabetic effect (Bertoglio et al 2011).…”

Section: Health Impact Of Legumesmentioning

confidence: 99%

Grain legume decline and potential recovery in European agriculture: a review

Zander

Amjath-Babu

Preißel

et al. 2016

Agron. Sustain. Dev.

166

157

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Sustainable development of agriculture is at the core of agricultural policy debates in Europe. There is a consensus that diversification of cropping would support sustainable development. However, a reduction in legume cultivation has been observed in the EU during the last decades. This decline has induced, in turn, a deficit of proteins and a reduction of ecosystem services provided by legumes. Therefore, we analysed the mechanisms that shape agricultural systems to identify leverage points for reviving European legume production. Specifically, we reviewed the factors that affect the market and non-market value of legumes and the relevant agricultural policies. We characterized the decline in legume cropping as an outcome of the dominance of economic forces that favour specialization of production systems over diversification. We found that the value of market outputs of legumes per unit area is relatively low and volatile, with a 25-78 % variation in pea gross margins, which reduces market competitiveness. We observed that the value of systeminternal outputs of legumes such as the nitrogen fixed, of 130 to 153 kg N ha; crop protection services that reduce agrochemical costs, by 20-25 % in cereals; and yield enhancements of subsequent crops, of 0.2 to 1.6 t ha −1 in cereals, are often underestimated. In addition, markets fail to translate external effects of legumes such as biodiversity enhancement, reduction in emissions, of up to 50 % in N 2 O, and soil improvements into economic benefits. Current policies support legumes through selected mechanisms such as ecological focus areas, agri-environmental programmes and sparse coupled support measures. Domestic cultivation of legumes could be supported through trade policies such as import restrictions on genetically modified soybean or new mechanisms to appreciate non-market outputs including payments for ecosystem services and carbon markets. In addition, development of new value chains, niche markets, scaling-up of plant breeding efforts and dissemination of information is required.

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Section: Health Impact Of Legumesmentioning

confidence: 99%

Grain legume decline and potential recovery in European agriculture: a review

Zander

Amjath-Babu

Preißel

et al. 2016

Agron. Sustain. Dev.

166

157

View full text Add to dashboard Cite

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“…The studies in the area of dyslipidaemia prevention were stimulated by the similarities of the composition of lupin and soybean, which is one of the main functional ingredient for dyslipidaemia prevention (Harland & Haffner, 2008;Jenkins, Mirrahimi, Srichaikul, Berryman, Wang, Carleton, et al, 2010;C R Sirtori, Eberini, & Arnoldi, 2007).…”

Section: Prevention Of Dyslipidaemiamentioning

confidence: 99%

The health benefits of sweet lupin seed flours and isolated proteins

Arnoldi

Boschin

Zanoni

2015

Journal of Functional Foods

117

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Abstract.The interest for lupin is continuously growing: one driving force are the numerous studies showing it provides useful health benefits. This review discusses available literature in the area of dyslipidaemia, diabetes, and hypertension prevention, providing hints on the mechanism of action.The addition of lupin protein to the diet of different models of hypercholesterolaemia, such as rat, rabbit, hamster and pig, induce decreases of total and non-HDL cholesterol. The clinical investigations on the cholesterol lowering activity provided controversial results. Those involving hypercholesterolaemic subjects and based on improved lupin foods gave statistically significant total and/or LDL-cholesterol reductions: both protein and fibre are relevant. The moderate hypotensive activity observed in some studies is probably linked to digestion-released ACE-inhibitory peptides.The hypoglycaemic activity, observed in post-prandial studies, is due to gamma-conglutin, a specific protein fraction. All this information suggests that lupin seeds may become a source of ingredients of innovative functional foods.Abbreviations: ACE, angiotensin converting enzyme; Akt, protein kinase B; DBP; diastolic blood pressure; GSK3, glycogen synthase kinase 3; HDL-C, high-density-lipoprotein cholesterol;HMGCoA, 3-hydroxy-3-methylglutaryl coenzyme A; LDL-C, low-density-lipoprotein cholesterol; NL-LUP, narrow-leaf lupin protein isolate; NPS, non-starch polysaccharides; PI3K, phosphatidylinositol 3'-kinase; SBP, systolic blood pressure; SCAP, SREBP-cleavage activating protein; SREBP, sterol regulatory element binding protein; TAG, triacylglycerides; TOC, tocopherol; W-LUP, white lupin protein isolate.

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“…The major influence of baseline cholesterolaemia on the final effect of soya proteins was highlighted in an editorial (121) . A recent systematic metaanalysis of available randomised controlled studies mainly in subjects with moderate hypercholesterolaemia confirmed that the inclusion in the diet of a modest amount of soya protein (25 g) produces a highly significant reduction of total cholesterol and LDL-C, equivalent to about 6 % LDL-C reduction (122) . The cholesterol-reducing effect of soya proteins, potentially leading to a reduced cardiovascular risk, became the basis for the US Food and Drug Administration approval of the health claim for the role of soya protein consumption in coronary disease risk reduction (123) .…”

Section: Soya Proteinsmentioning

confidence: 98%

Functional foods for dyslipidaemia and cardiovascular risk prevention

et al. 2009

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A food can be regarded as ‘functional’ if it can demonstrate a beneficial efficacy on one or more target functions in the body in a convincing way. Beyond adequate nutritional qualities, functional foods should either improve the state of health and wellbeing and/or reduce the risk of disease. Functional foods that are marketed with claims of heart disease reduction focus primarily on the major risk factors, i.e. cholesterol, diabetes and hypertension. Some of the most innovative products are designed to be enriched with ‘protective’ ingredients, believed to reduce risk. They may contain, for example, soluble fibre (from oat and psyllium), useful both for lowering cholesterol and blood pressure, or fructans, effective in diabetes. Phytosterols and stanols lower LDL-cholesterol in a dose-dependent manner. Soya protein is more hypocholesterolaemic in subjects with very high initial cholesterol and recent data indicate also favourable activities in the metabolic syndrome.n-3 Fatty acids appear to exert significant hypotriacylglycerolaemic effects, possibly partly responsible for their preventive activity. Dark chocolate is gaining much attention for its multifunctional activities, useful both for the prevention of dyslipidaemia as well as hypertension. Finally, consensus opinions about tea and coffee have not emerged yet, and the benefits of vitamin E, garlic, fenugreek and policosanols in the management of dyslipidaemia and prevention of arterial disease are still controversial.

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Systematic review, meta-analysis and regression of randomised controlled trials reporting an association between an intake of circa 25g soya protein per day and blood cholesterol

Cited by 138 publications

References 53 publications

Grain legume decline and potential recovery in European agriculture: a review

Grain legume decline and potential recovery in European agriculture: a review

The health benefits of sweet lupin seed flours and isolated proteins

Functional foods for dyslipidaemia and cardiovascular risk prevention

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