Systematic Review Focusing on the Excretion and Protection Roles of Sweat in the Skin

Yan, Ping; Cui, Xiaojie; Liu, Yanhua; Li, Yaoyin; Liu, Jian; Cheng, Biao

doi:10.1159/000357524

Cited by 22 publications

(11 citation statements)

References 39 publications

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“…The ability to lose heat is affected by the prevailing outside temperature as well as humidity. However, it is increasingly being recognised that sweat has a number of other important roles which include the production and secretion of a range of AMPs such as LL-37, lactoferrin and dermicidin, an AMP unique to skin [187–189], as well as compounds that maintain skin condition (barrier function) and skin lubricants [190]. Sweat glands also contain stem cells important for renewing skin after wounding and burns [186, 191].…”

Section: Role Of Cftr In Sweat Gland Physiologymentioning

confidence: 99%

Role of CFTR in epithelial physiology

Saint‐Criq

Gray

2016

Cell. Mol. Life Sci.

303

291

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Salt and fluid absorption and secretion are two processes that are fundamental to epithelial function and whole body fluid homeostasis, and as such are tightly regulated in epithelial tissues. The CFTR anion channel plays a major role in regulating both secretion and absorption in a diverse range of epithelial tissues, including the airways, the GI and reproductive tracts, sweat and salivary glands. It is not surprising then that defects in CFTR function are linked to disease, including life-threatening secretory diarrhoeas, such as cholera, as well as the inherited disease, cystic fibrosis (CF), one of the most common life-limiting genetic diseases in Caucasian populations. More recently, CFTR dysfunction has also been implicated in the pathogenesis of acute pancreatitis, chronic obstructive pulmonary disease (COPD), and the hyper-responsiveness in asthma, underscoring its fundamental role in whole body health and disease. CFTR regulates many mechanisms in epithelial physiology, such as maintaining epithelial surface hydration and regulating luminal pH. Indeed, recent studies have identified luminal pH as an important arbiter of epithelial barrier function and innate defence, particularly in the airways and GI tract. In this chapter, we will illustrate the different operational roles of CFTR in epithelial function by describing its characteristics in three different tissues: the airways, the pancreas, and the sweat gland.

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Section: Role Of Cftr In Sweat Gland Physiologymentioning

confidence: 99%

Role of CFTR in epithelial physiology

Saint‐Criq

Gray

2016

Cell. Mol. Life Sci.

303

291

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“…Exocrine glands produce and secrete a large variety of fluids that are important for digestion, lubrication, lactation and thermoregulation [28–32]. Examples of exocrine glands include sweat, salivary, lacrimal, and mammary glands.…”

Section: Basic Mechanisms Of Salt and Fluid Secretionmentioning

confidence: 99%

Regulation of epithelial ion transport in exocrine glands by store-operated Ca2+ entry

Concepcion

Feske

2017

Cell Calcium

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Store-operated Ca2+ entry (SOCE) is a conserved mechanism of Ca2+ influx that regulates Ca2+ signaling in many cell types. SOCE is activated by depletion of endoplasmic reticulum (ER) Ca2+ stores in response to physiological agonist stimulation. After it was first postulated by J.W. Putney Jr. in 1986, SOCE has been described in a large number of non-excitable cell types including secretory cells of different exocrine glands. Here we discuss the mechanisms by which SOCE controls salt and fluid secretion in exocrine glands, with a special focus on eccrine sweat glands. In sweat glands, SOCE plays an important, non-redundant role in regulating the function of Ca2+-activated Cl− channels (CaCC), Cl− secretion and sweat production. In the absence of key regulators of SOCE such as the CRAC channel pore subunit ORAI1 and its activator STIM1, the Ca2+-activated chloride channel TMEM16A is inactive and fails to secrete Cl−, resulting in anhidrosis in mice and human patients.

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“…Generally, intestinal tract is an alimentary organ for digestion and absorption. According to general understanding of evolution, other organs like skin [7] and intestinal tract [8] could also share the excretory function. Although there were clinic clues [9, 10] that the intestinal tract could be an alternative excretory organ, the effect of intestinal tract for excretion was not fully understood.…”

Section: Discussionmentioning

confidence: 99%

“…Actually, kidney, though, is the main but not the only organ for excretion. Then, other organs, like skin [7] and intestinal tract [8], could partly undertake the task, because some metabolites could be detected in sweat [7], and intestinal dialysis [9, 10] was helpful for renal failure patients to improve their symptoms by lowering BUN and serum creatinine. However, the role of intestinal tract in excretion was ignored to a large extent in both clinic and experiment studies, and the fact was not proved with experimental results.…”

Section: Introductionmentioning

confidence: 99%

Excretory Function of Intestinal Tract Enhanced in Kidney Impaired Rats Caused by Adenine

Gao

et al. 2016

The Scientific World Journal

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The main aim of the study was to prove the compensative effect of intestine for renal function. Rat kidney was impaired by intragastrically administrating adenine (400 mg per day for 5 days). Intestinal tract was harvested and equally divided into 20 segments except cecum. Kidneys were harvested and histologically examined with hematoxylin-eosin staining kits. Uric acid, urea (BUN), and creatinine in serum were determined with assay kits, and BUN and creatinine in every intestinal segment were also determined. The results showed that adenine was able to increase uric acid level in serum from 20.98 ± 6.98 μg/mL to 40.77 ± 7.52 μg/mL and cause renal function damage with BUN (from 3.87 ± 0.62 mM to 12.33 ± 3.27 mM) and creatinine (from 51.48 ± 6.98 μM to 118.25 ± 28.63 μM) increasing in serum and with abnormally micromorphological changes in kidney. The amount of BUN and creatinine distributed in intestinal tract was positively correlated with those in blood. In impaired renal function rats, the amount of BUN (from 4.26 ± 0.21 μMole to 10.72 ± 0.55 μMole) and creatinine (from 681.4 ± 23.3 nMole to 928.7 ± 21.3 nMole) distributed in intestinal tract significantly increased. All the results proved that intestinal tract had excretory function compensative for renal function.

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Systematic Review Focusing on the Excretion and Protection Roles of Sweat in the Skin

Cited by 22 publications

References 39 publications

Role of CFTR in epithelial physiology

Role of CFTR in epithelial physiology

Regulation of epithelial ion transport in exocrine glands by store-operated Ca2+ entry

Excretory Function of Intestinal Tract Enhanced in Kidney Impaired Rats Caused by Adenine

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