Systematic review: fluoroquinolones for the treatment of intra‐abdominal surgical infections

Falagas, Matthew E.; Matthaiou, Dimitrios K.; Bliziotis, Ioannis A.

doi:10.1111/j.1365-2036.2006.03154.x

Cited by 17 publications

(10 citation statements)

References 46 publications

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“…Many studies have proved fluoroquinolones in association with metronidazole an effective therapeutic option for the treatment of patients with intra-abdominal infections since their discovery [127]. The combination of ciprofloxacin/metronidazole has been one of the most commonly used regimens for the treatment of patients with severe complicated intra-abdomianl infections in the last years.…”

Section: Antimicrobial Therapy In Intra-abdominal Infectionsmentioning

confidence: 99%

A focus on intra-abdominal infections

2010

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Complicated intra-abdominal infections are an important cause of morbidity and are frequently associated with poor prognosis, particularly in higher risk patients.Well defined evidence-based recommendations for intra-abdominal infections treatment are partially lacking because of the limited number of randomized-controlled trials.Factors consistently associated with poor outcomes in patients with intra-abdominal infections include increased illness severity, failed source control, inadequate empiric antimicrobial therapy and healthcare-acquired infection.Early prognostic evaluation of complicated intra-abdominal infections is important to select high-risk patients for more aggressive therapeutic procedures.The cornerstones in the management of complicated intra-abdominal infections are both source control and antibiotic therapy.The timing and the adequacy of source control are the most important issues in the management of intra-abdominal infections, because inadequate and late control of septic source may have a negative effect on the outcomes.Recent advances in interventional and more aggressive techniques could significantly decrease the morbidity and mortality of physiologically severe complicated intra-abdominal infections, even if these are still being debated and are yet not validated by limited prospective trials.Empiric antimicrobial therapy is nevertheless important in the overall management of intra-abdominal infections. Inappropriate antibiotic therapy may result in poor patient outcomes and in the appearance of bacterial resistance.Antimicrobial management is generally standardised and many regimens, either with monotherapy or combination therapy, have proven their efficacy. Routine coverage especially against Enterococci and candida spp is not always recommended, but can be useful in particular clinical conditions. A de escalation approach may be recommended in patients with specific risk factors for multidrug resistant infections such as immunodeficiency and prolonged antibacterial exposure.Therapy should focus on the obtainment of adequate source control and adequate use of antimicrobial therapy dictated by individual patient risk factors. Other critical issues remain debated and more controversies are still open mainly because of the limited number of randomized controlled trials.

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Section: Antimicrobial Therapy In Intra-abdominal Infectionsmentioning

confidence: 99%

A focus on intra-abdominal infections

2010

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“…In addition all the fluoroquinolones are rapidly and almost completely absorbed from the gastrointestinal tract [193,194]. The combination of ciprofloxacin/metronidazole has been one of the most commonly used regimens for the treatment of patients with complicated IAIs in the last years.…”

Section: Extra-biliary Community-acquired Intra-abdominal Infectionsmentioning

confidence: 99%

WSES consensus conference: Guidelines for first-line management of intra-abdominal infections

et al. 2011

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Intra-abdominal infections are still associated with high rate of morbidity and mortality.A multidisciplinary approach to the management of patients with intra-abdominal infections may be an important factor in the quality of care. The presence of a team of health professionals from various disciplines, working in concert, may improve efficiency, outcome, and the cost of care.A World Society of Emergency Surgery (WSES) Consensus Conference was held in Bologna on July 2010, during the 1st congress of the WSES, involving surgeons, infectious disease specialists, pharmacologists, radiologists and intensivists with the goal of defining recommendations for the early management of intra-abdominal infections.This document represents the executive summary of the final guidelines approved by the consensus conference.

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“…Despite the challenges of antimicrobial research, currently fifteen compounds are in Phase I clinical trials or beyond: four Grampositive spectrum glycopeptides [14], five beta-lactams [15], three quinolones [16], a dihydrofolate reductase inhibitor [17], an oxazolidinone [18] and a tetracycline [19] but in addition to these compounds novel antimicrobial agents will be needed to sustain the ability to treat bacterial infections in future.…”

Section: Importance Of New Antibioticsmentioning

confidence: 99%

Computer Simulation of Antimicrobial Peptides

Mátyus

Kandt²,

Tieleman³

2007

CMC

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Naturally occurring and synthetic peptides may be a novel class of clinically useful antibiotics. A large body of experimental data on structure function relationships for such peptides is available, but the molecular mechanism of their action remains elusive in most cases. Computer simulations can give detailed insights into the interactions between peptides and lipid bilayers, at least one crucial step in the antimicrobial mechanism. Here we review recent simulations of antimicrobial peptides and discuss potential future contributions of computer simulations in understanding and ultimately designing antimicrobial peptides.

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Systematic review: fluoroquinolones for the treatment of intra‐abdominal surgical infections

Abstract: SUMMARY BackgroundIntra-abdominal infections result in substantial morbidity and mortality. Fluoroquinolones are among the various regimens that are used for the treatment of these infections.

Cited by 17 publications

References 46 publications

A focus on intra-abdominal infections

A focus on intra-abdominal infections

WSES consensus conference: Guidelines for first-line management of intra-abdominal infections

Computer Simulation of Antimicrobial Peptides

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