Systematic Review: Efficacy of Silicone Microimplants (Macroplastique®) Therapy for Stress Urinary Incontinence in Adult Women

Meulen, P.H. ter; Berghmans, Luc; Kerrebroeck, Ph. E. V. A. van

doi:10.1016/s0302-2838(03)00374-9

Cited by 52 publications

(33 citation statements)

References 57 publications

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“…[34][35][36] It is composed of solid polydimethylsiloxane suspended in inert gel. The systematic review could not recommend Macroplastique due to insufficient evidence, 35 but three RCTs have been published since that time (Table 1).…”

Section: Macroplastiquementioning

confidence: 99%

“…The systematic review could not recommend Macroplastique due to insufficient evidence, 35 but three RCTs have been published since that time (Table 1). 16,17,34 In women with urethral hypermobility and SUI, Macroplastique (24 women) had higher cure and improvement rate of 70.8% compared with a pelvic floor exercise program (21 women) 28.5% (P = 0.029). This study did not follow both groups past 3 months and with small treatment groups few definitive conclusions can be drawn.…”

Section: Macroplastiquementioning

confidence: 99%

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The treatment of female stress urinary incontinence: an evidenced-based review

Pelletier-Cameron¹,

Haraway²

2011

RRU

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Objective: To review the literature on the surgical and nonsurgical treatment options for stress urinary incontinence in women, focusing exclusively on randomized clinical trials and high quality meta-analyses. Materials and methods: A computer-aided and manual search for published randomized controlled trials and high quality meta-analyses investigating both conservative and surgical treatment options for stress urinary incontinence. In the case of a treatment that is not studied in these formats large case series have been used. Results: Articles were reviewed and the results summarized on pelvic floor physical therapy, pharmacotherapy, bulking agents, and surgery (open and minimally invasive). Conclusion: There are numerous high quality studies in the literature. It can be difficult to make definitive conclusions on the most appropriate treatment options due to the variability in the outcomes used to define success in these articles. There is also a dire lack of studies evaluating and comparing the surgical options for patients with intrinsic sphincter deficiency.

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Section: Macroplastiquementioning

confidence: 99%

Section: Macroplastiquementioning

confidence: 99%

The treatment of female stress urinary incontinence: an evidenced-based review

Pelletier-Cameron¹,

Haraway²

2011

RRU

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“…In studies, success rates vary from 58% (long term) to 73% (short term) [9]. Macroplastique® is a bulking agent that consists of solid polydimethylsiloxane particles with a mean maximum diameter of 209 μm [10].…”

Section: Introductionmentioning

confidence: 99%

Effects of Macroplastique® Implantation System for stress urinary incontinence and urethral hypermobility in women

et al. 2008

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A study was carried out to evaluate efficacy of Macroplastique® (MPQ) Implantation System (MIS) in women with urodynamic stress urinary incontinence (SUI) and urethral hypermobility after an unsuccessful conservative treatment. This is a prospective randomized controlled trial in women without previous incontinence surgery. Twenty-four women received MPQ. Twenty-one controls underwent a pelvic floor muscle exercises home program. Follow-up was at 3 months and the MPQ group also at 12 months. At 3 months, pad usage decreased significantly more in the MPQ group than in the control group (p= 0.015). According to physician and patient self-assessment, respectively, 71% and 63% women in the MPQ group were considered cured or markedly improved. This was significantly higher compared to controls. There was a significant higher increase of Incontinence Quality-of-Life questionnaire score in the MPQ group compared to controls (p= 0.017). Improvements in MPQ group at 3 months are sustained to 12 months. Adverse events were mild and transient. MIS is an acceptable option for women with SUI and urethral hypermobility.

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“…They reported a continence rate of 66.6% in the midurethral group and of 60% for the bladder neck group, respectively. They conclude that both procedures improve patients' satisfaction almost equally with a small advantage for midurethral injections.In this view, we would like to give our contribution to the argument as follows.It is well known that careful patient selection using optimal diagnostic tools is mandatory for achieving the maximal results of urethral bulking agent therapy [2]. Bulking agents injection is considered an effective procedure in women with stress SUI due to intrinsic sphincter deficiency (ISD) with urethral hypomobility [2].…”

mentioning

confidence: 99%

“…It is well known that careful patient selection using optimal diagnostic tools is mandatory for achieving the maximal results of urethral bulking agent therapy [2]. Bulking agents injection is considered an effective procedure in women with stress SUI due to intrinsic sphincter deficiency (ISD) with urethral hypomobility [2].…”

mentioning

confidence: 99%