Systematic Review Concerning the Care of Breast Cancer during Pregnancy with a Case Report of Breast Cancer during Triple Gestation

Abstract

Introduction:Cancer affects 1 woman over 1000 during the gestation of which the most common is the breast cancer. Its management is not yet well defined. The study aim is to carry out a systematic review to help achieve the most optimal management. This literature review will be accompanied by a case report concerning a pregnant with a triple fetus complicated by pre-eclampsia and breast cancer at 28 weeks. Methods:We performed a systematic review. The potentially eligible studies were identified by searching the United States National Library of Medicine (PubMed) electronic database, from January 2001 through December 2020, using combinations of the following keywords: (breast cancer) AND (pregnancy) more or less (pre-eclampsia). For pre-eclampsia, the research spanned from January 2010 to December 2020. The Preferred Reporting Items for Systematic review and Meta-Analysis (PRISMA) were used. We examined the retrieved articles and discarded duplicated ones. We also excluded unrelated studies through careful browsing of titles and abstracts of all retrieved publications; studies with an inadequate design, case reports with a low number of participants, and publications in languages other than English were removed.Results: 5018 articles were found concerning breast cancer during pregnancy and 43 on pre-eclampsia and breast cancer, only 54 were kept. Conclusion:Diagnostic and extension assessment of breast cancer during pregnancy is like without pregnancy, the treatment is modulated according to gestational age. The surgery is possible during all trimester. Chemotherapy is prohibited during the first trimester. The target therapy and hormonotherapy are not possible during the pregnancy.