Systematic Review Comparing the Efficacy and Safety of Collagenase Clostridium Histolyticum (Xiaflex®) Injection with Surgical Fasciectomy for the Treatment of Dupuytren’s Contracture

Abstract

intraoperative revision for malplaced screws during the index procedure. Results of 10 case series and a European registry show rates of pedicle screw placement accuracy (0 mm to ≤ 2 mm) between 95% and 100% with 3D O-arm surgical imaging with navigation compared to 84%-95% reported for various current practice options from multiple meta-analyses. In addition, accuracy rates of between 72% and 92% have been reported for 2D C-arm without navigation. Economic studies demonstrated 3D O-arm surgical imaging with navigation has the potential to reduce the cost of fusion procedures in Europe and the USA by negating the need for pre-operative and post-operative imaging associated with current standardof-care, reducing the need for reoperations for screw revision, shortening length of procedures and OR time. It has been estimated that it could reduce the cost of hospitalization for spinal surgery by at least 3.8%. ConClusions: Current evidence shows 3D O-arm surgical imaging with navigation substantially reduces the human and financial burden of patients during spinal stabilization surgery compared with standard practice. PMS11 Evaluating thE Efficacy of BioSiMilar inflixiMaB with thE acr50 rESPonSE in PatiEntS with rhEuMatoid arthritiS; a MEta-analySiS in BayESian fraMEwork