Systematic review and meta-analysis regarding maternal apelin in pregnant women with and without preeclampsia

Fuentes-Carrasco, Marta; Ruíz-Román, Rebeca; Savirón-Cornudella, Ricardo; Pérez-Roncero, Gonzalo; López‐Baena, María T.; Pérez‐López, Faustino R.

doi:10.1080/09513590.2022.2122433

Cited by 2 publications

(2 citation statements)

References 41 publications

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“…The apelinergic-axis (apelin/receptor APJ) is involved in many physiological and pathological processes. Although controversial, several studies indicate changes in apelin levels in obesity and PE (Daviaud et al, 2006; Fuentes-Carrasco & Ruíz-Román, 2022; Inuzuka et al, 2013; Liu et al, 2019). Our results showed lower apelin placental expression in overweight/obese women and an inverse correlation between pre-gestational BMI and pre-pregnancy weight.…”

Section: Discussionmentioning

confidence: 99%

Apelin and Visfatin Expression in Placental Tissue in Women With Preeclampsia and Overweight/Obesity

Braga

Silva

Lelis

et al. 2023

Biological Research For Nursing

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Background Preeclampsia (PE) is a multifunctional and multisystem disorder. Several factors favor the development of PE, including obesity. Cytokines are also expressed in the placenta, predisposing to local alterations that favor the development of distinct pathological processes, including PE. This study aimed to evaluate the apelin and visfatin mRNA expression in the placental tissue of women with preeclampsia and overweight/obesity and correlates with maternal and fetal variables. Methods A cross-sectional analytical study was performed with 60 pregnant women and their newborns. Clinical, anthropometric, and laboratory variables were collected. Placental tissue samples were obtained, and the apelin and visfatin mRNA expression levels were assessed by qRT-PCR. Results The main findings evidenced lower levels of apelin expression in overweight/obese women, accompanied by a negative correlation with BMI and pre-pregnancy weight; a higher expression of apelin was also observed in women with late PE and no personal history of PE. For visfatin levels, higher expression levels were observed in women with late PE and term delivery. Furthermore, a positive correlation was observed between visfatin levels and fetal anthropometric parameters, such as weight, length, and head circumference. Conclusion Apelin levels were less expressed in overweight/obese women. Apelin and visfatin levels were correlated/associated with maternal-fetal variables.

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Section: Discussionmentioning

confidence: 99%

Apelin and Visfatin Expression in Placental Tissue in Women With Preeclampsia and Overweight/Obesity

Braga

Silva

Lelis

et al. 2023

Biological Research For Nursing

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“…Nevertheless, two teams also studied apelin-13 and also found decreased serum levels [104,105]. On the other hand, a recent review determined that, although there was a high heterogeneity within available studies, there was no difference in circulating maternal apelin levels between the two patient groups [106]. Nevertheless, it was observed that patients with PE had a higher BMI and lower gestational age and birthweight at delivery.…”

Section: Preeclampsia (Pe)mentioning

confidence: 99%

The Apelinergic System in Pregnancy

Pécheux

Correia-Branco

Cohen

et al. 2023

IJMS

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The apelinergic system is a highly conserved pleiotropic system. It comprises the apelin receptor apelin peptide jejunum (APJ) and its two peptide ligands, Elabela/Toddler (ELA) and apelin, which have different spatiotemporal localizations. This system has been implicated in the regulation of the adipoinsular axis, in cardiovascular and central nervous systems, in carcinogenesis, and in pregnancy in humans. During pregnancy, the apelinergic system is essential for embryo cardiogenesis and vasculogenesis and for placental development and function. It may also play a role in the initiation of labor. The apelinergic system seems to be involved in the development of placenta-related pregnancy complications, such as preeclampsia (PE) and intrauterine growth restriction, but an improvement in PE-like symptoms and birth weight has been described in murine models after the exogenous administration of apelin or ELA. Although the expression of ELA, apelin, and APJ is altered in human PE placenta, data related to their circulating levels are inconsistent. This article reviews current knowledge about the roles of the apelinergic system in pregnancy and its pathophysiological roles in placenta-related complications in pregnancy. We also discuss the challenges in translating the actors of the apelinergic system into a marker or target for therapeutic interventions in obstetrics.

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Systematic review and meta-analysis regarding maternal apelin in pregnant women with and without preeclampsia

Cited by 2 publications

References 41 publications

Apelin and Visfatin Expression in Placental Tissue in Women With Preeclampsia and Overweight/Obesity

Apelin and Visfatin Expression in Placental Tissue in Women With Preeclampsia and Overweight/Obesity

The Apelinergic System in Pregnancy

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