Systematic review and meta-analysis of application of fibrin sealant after liver resection

Abstract

This study demonstrated a modest benefit of FS over no FS, topical hemostatic agents and ABC in controlling intraoperative bleeding from the raw liver surface after liver resection. But there is no evidence that FS is beneficial to patients in reducing amount of drainage and drainage duration.

Safety and Hemostatic Effectiveness of the Fibrin Pad for Severe Soft‐Tissue Bleeding During Abdominal, Retroperitoneal, Pelvic, and Thoracic (Non‐cardiac) Surgery: A Randomized, Controlled, Superiority Trial

“…Although most TAHs are effective against moderately intense bleeding, they are less effective against severe bleeding because they ''float off'' tissue owing to lack of adhesion [6,[12][13][14]. The fibrin pad (FP) has been developed to treat bleeding across a spectrum of intensities.…”

Anesthesia for Hepatobiliary Surgery

“…Control of residual bleeding of the resected liver surface may be achieved by use of argon beam coagulation or the spray application of fibrin glue. 65,66 Anesthetic Technique Intraoperative Anesthetic techniques during hepatic resection aim to reduce the need for vascular occlusion techniques by minimizing the potential for blood loss through optimum fluid Anesthesia for Hepatobiliary Surgery management and the avoidance of unnecessary blood transfusion through appropriate correction of coagulopathy.…”

Fibrin sealants: surgical hemostat, sealant and adhesive

“…FSs are being explored for anal fistula closure, adhesion prevention, seroma reduction, as well as urologic, vascular, intestinal and nerve anastomoses [20,[36][37][38][39][40][41][42][43]. The adhesive properties are being exploited as an alternative fixation technique in various hernia repairs, as a means of pain reduction from reduced suture or tack placement, or for pain reduction after plastic surgical procedures [44][45][46][47][48][49][50].…”