Systematic review and meta-analysis of glyphosate exposure and risk of lymphohematopoietic cancers

Chang, Ellen T.; Delzell, Elizabeth

doi:10.1080/03601234.2016.1142748

Cited by 51 publications

(51 citation statements)

References 75 publications

(245 reference statements)

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“…Upon further review, two of these references were excluded: Lee et al (2005) because it did not focus on NHL or MM (only glioma) and the meta-analysis of Schinasi and Leon (2014) because our focus was on the primary literature. A meta-analysis by Chang and Delzell (2016) that was pending publication at the time of our review would have been excluded for the same reason.…”

Section: Literature Search and Included/excluded Published Papersmentioning

confidence: 99%

Glyphosate epidemiology expert panel review: a weight of evidence systematic review of the relationship between glyphosate exposure and non-Hodgkin’s lymphoma or multiple myeloma

Acquavella

Garabrant

Marsh

et al. 2016

Critical Reviews in Toxicology

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We conducted a systematic review of the epidemiologic literature for glyphosate focusing on nonHodgkin's lymphoma (NHL) and multiple myeloma (MM) -two cancers that were the focus of a recent review by an International Agency for Research on Cancer Working Group. Our approach was consistent with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for systematic reviews. We evaluated each relevant study according to a priori criteria for study quality: adequacy of study size, likelihood of confounding, potential for other biases and adequacy of the statistical analyses. Our evaluation included seven unique studies for NHL and four for MM, all but one of which were case control studies for each cancer. For NHL, the case-control studies were all limited by the potential for recall bias and the lack of adequate multivariate adjustment for multiple pesticide and other farming exposures. Only the Agricultural Health (cohort) Study met our a priori quality standards and this study found no evidence of an association between glyphosate and NHL. For MM, the case control studies shared the same limitations as noted for the NHL case-control studies and, in aggregate, the data were too sparse to enable an informed causal judgment. Overall, our review did not find support in the epidemiologic literature for a causal association between glyphosate and NHL or MM. ARTICLE HISTORY

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Section: Literature Search and Included/excluded Published Papersmentioning

confidence: 99%

Glyphosate epidemiology expert panel review: a weight of evidence systematic review of the relationship between glyphosate exposure and non-Hodgkin’s lymphoma or multiple myeloma

Acquavella

Garabrant

Marsh

et al. 2016

Critical Reviews in Toxicology

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“…Among environmental factors, glyphosate or its formulated products have been indicated to be linked with increased incidence of and mortality by multiple diseases (including cataract related to subsequent breast carcinoma) and cancer (Swanson et al, 2014;Singh et al, 2017). In the latter category, associations were found with non-Hodgkin lymphoma or multiple myeloma incidence (Hardell and Eriksson, 1999;McDuffie et al, 2001;Hardell et al, 2002;De Roos et al, 2003Eriksson et al, 2008;Schinasi and Leon, 2014;Mesnage et al, 2015b), although other reviews claimed no causal relationship between exposure to glyphosate and lymphohematopoietic cancers (Acquavella et al, 2016;Chang and Delzell, 2016;Williams et al, 2016a). Some of these findings have been questioned by Monsanto (Acquavella et al, 1999) and a recent cohort prospective epidemiology study carried out in the US on 57310 licensed pesticide applicators and 32347 spouses in Iowa or North Carolina States found no apparent correlation between glyphosate use and solid tumor or lymphoid malignancies, including non-Hodgkin lymphoma, except for increased risk of acute myeloid leukemia in case of high exposure (Andreotti et al, 2018).…”

Section: Registration Of Glyphosate In the European Unionmentioning

confidence: 99%

Re-registration Challenges of Glyphosate in the European Union

Székacs

Darvas

2018

Front. Environ. Sci.

104

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“…ha −1 . Even though the safe use of glyphosate has been under discussion for many years (Chang and Delzell, 2016), it was used in order to preserve the same killing method in all the campaigns in this long-term experiment under conservation tillage management. All of the CC residues were left on top of the soil.…”

Section: Experimental Design and Agronomic Managementmentioning

confidence: 99%

Effect of cover crops on greenhouse gas emissions in an irrigated field under integrated soil fertility management

et al. 2016

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Abstract. Agronomical and environmental benefits are associated with replacing winter fallow by cover crops (CCs). Yet, the effect of this practice on nitrous oxide (N 2 O) emissions remains poorly understood. In this context, a field experiment was carried out under Mediterranean conditions to evaluate the effect of replacing the traditional winter fallow (F) by vetch (Vicia sativa L.; V) or barley (Hordeum vulgare L.; B) on greenhouse gas (GHG) emissions during the intercrop and the maize (Zea mays L.) cropping period. The maize was fertilized following integrated soil fertility management (ISFM) criteria. Maize nitrogen (N) uptake, soil mineral N concentrations, soil temperature and moisture, dissolved organic carbon (DOC) and GHG fluxes were measured during the experiment. Our management (adjusted N synthetic rates due to ISFM) and pedo-climatic conditions resulted in low cumulative N 2 O emissions (0.57 to 0.75 kg N 2 O-N ha −1 yr −1 ), yield-scaled N 2 O emissions (3-6 g N 2 O-N kg aboveground N uptake −1 ) and N surplus (31 to 56 kg N ha −1 ) for all treatments. Although CCs increased N 2 O emissions during the intercrop period compared to F (1.6 and 2.6 times in B and V, respectively), the ISFM resulted in similar cumulative emissions for the CCs and F at the end of the maize cropping period. The higher C : N ratio of the B residue led to a greater proportion of N 2 O losses from the synthetic fertilizer in these plots when compared to V. No significant differences were observed in CH 4 and CO 2 fluxes at the end of the experiment. This study shows that the use of both legume and nonlegume CCs combined with ISFM could provide, in addition to the advantages reported in previous studies, an opportunity to maximize agronomic efficiency (lowering synthetic N requirements for the subsequent cash crop) without increasing cumulative or yieldscaled N 2 O losses.

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Systematic review and meta-analysis of glyphosate exposure and risk of lymphohematopoietic cancers

Cited by 51 publications

References 75 publications

Glyphosate epidemiology expert panel review: a weight of evidence systematic review of the relationship between glyphosate exposure and non-Hodgkin’s lymphoma or multiple myeloma

Glyphosate epidemiology expert panel review: a weight of evidence systematic review of the relationship between glyphosate exposure and non-Hodgkin’s lymphoma or multiple myeloma

Re-registration Challenges of Glyphosate in the European Union

Effect of cover crops on greenhouse gas emissions in an irrigated field under integrated soil fertility management

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