Systematic review and meta-analysis of the efficacy of clinically tested protectants of cisplatin nephrotoxicity

Casanova, Alfredo G.; Hernández-Sánchez, María Teresa; López‐Hernández, Francisco J.; Martı́nez-Salgado, Carlos; Prieto, Marta; Vicente-Vicente, Laura; Morales, Ana Isabel

doi:10.1007/s00228-019-02771-5

Cited by 36 publications

(27 citation statements)

References 55 publications

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“…New strategies based on the co-administration of nephroprotectors are under development. Candidate nephroprotectors include magnesium formulations [ 6 , 9 ] and, most prominently, a variety of antioxidants [ 6 , 20 , 21 ]. Flavonoids are a family of nephroprotective polyphenolic products derived from vegetables, fruits, nuts, and wine, with strong antioxidant properties [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

A Micellar Formulation of Quercetin Prevents Cisplatin Nephrotoxicity

Casanova

Prieto

Colino

et al. 2021

IJMS

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The antioxidant flavonoid quercetin has been shown to prevent nephrotoxicity in animal models and in a clinical study and is thus a very promising prophylactic candidate under development. Quercetin solubility is very low, which handicaps clinical application. The aim of this work was to study, in rats, the bioavailability and nephroprotective efficacy of a micellar formulation of Pluronic F127-encapsulated quercetin (P-quercetin), with improved hydrosolubility. Intraperitoneal administration of P-quercetin leads to an increased plasma concentration and bioavailability of quercetin compared to the equimolar administration of natural quercetin. Moreover, P-quercetin retains overall nephroprotective properties, and even slightly improves some renal function parameters, when compared to natural quercetin. Specifically, P-quercetin reduced the increment in plasma creatinine (from 3.4 ± 0.5 to 1.2 ± 0.3 mg/dL) and urea (from 490.9 ± 43.8 to 184.1 ± 50.1 mg/dL) and the decrease in creatinine clearance (from 0.08 ± 0.02 to 0.58 ± 0.19 mL/min) induced by the nephrotoxic chemotherapeutic drug cisplatin, and it ameliorated histological evidence of tubular damage. This new formulation with enhanced kinetic and biopharmaceutical properties will allow for further exploration of quercetin as a candidate nephroprotector at lower dosages and by administration routes oriented towards its clinical use.

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Section: Introductionmentioning

confidence: 99%

A Micellar Formulation of Quercetin Prevents Cisplatin Nephrotoxicity

Casanova

Prieto

Colino

et al. 2021

IJMS

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“…1 Patients that survive AKI are predisposed to develop chronic kidney disease (CKD). 2 Since there is a lack of an effective therapeutic approach for cisplatininduced AKI prevention and treatment, 3,4 risk factors that induce or promote AKI should be addressed during cisplatin treatment as carefully as possible.…”

Section: Introductionmentioning

confidence: 99%

Lansoprazole promotes cisplatin‐induced acute kidney injury via enhancing tubular necroptosis

Pang

Huang

et al. 2021

J Cellular Molecular Medi

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Acute kidney injury (AKI) is the main obstacle that limits the use of cisplatin in cancer treatment. Proton pump inhibitors (PPIs), the most commonly used class of medications for gastrointestinal complications in cancer patients, have been reported to cause adverse renal events. However, the effect of PPIs on cisplatin‐induced AKI remains unclear. Herein, the effect and mechanism of lansoprazole (LPZ), one of the most frequently prescribed PPIs, on cisplatin‐induced AKI were investigated in vivo and in vitro. C57BL/6 mice received a single intraperitoneal (i.p.) injection of cisplatin (18 mg/kg) to induce AKI, and LPZ (12.5 or 25 mg/kg) was administered 2 hours prior to cisplatin administration and then once daily for another 2 days via i.p. injection. The results showed that LPZ significantly aggravated the tubular damage and further increased the elevated levels of serum creatinine and blood urea nitrogen induced by cisplatin. However, LPZ did not enhance cisplatin‐induced tubular apoptosis, as evidenced by a lack of significant change in mRNA and protein expression of Bax/Bcl‐2 ratio and TUNEL staining. Notably, LPZ increased the number of necrotic renal tubular cells compared to that by cisplatin treatment alone, which was further confirmed by the elevated necroptosis‐associated protein expression of RIPK1, p‐RIPK3 and p‐MLKL. Furthermore, LPZ deteriorated cisplatin‐induced inflammation, as revealed by the increased mRNA expression of pro‐inflammatory factors including, NLRP3, IL‐1β, TNF‐α and caspase 1, as well as neutrophil infiltration. Consistently, in in vitro study, LPZ increased HK‐2 cell death and enhanced inflammation, compared with cisplatin treatment alone. Collectively, our results demonstrate that LPZ aggravates cisplatin‐induced AKI, and necroptosis may be involved in the exacerbation of kidney damage.

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“…Furthermore, there was no significant difference on the body weight or survival rate between the control group and the ONP group, suggesting that ONP possibly had no obvious toxicity. The clinical application of DDP shows that nephrotoxicity is one of its main side effects and may even lead to death (Casanova et al., 2020; Charlier et al., 2004). Based on the attenuation of body weight loss and the increasing of survival rate in mice, ONP was likely to have the potential to protect the kidneys.…”

Section: Resultsmentioning

confidence: 99%

A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin‐induced nephrotoxicity

Zhou

et al. 2021

Food Science & Nutrition

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Ophiocordyceps lanpingensis is an edible mushroom distributed over the south‐eastern part of the Tibet Plateau, which is also recognized as an effective ethnomedicine to alleviate diseases. This study explored the effects of a kind of Ophiocordyceps lanpingensis neutral polysaccharide (ONP) on RAW264.7 macrophages and cisplatin‐induced nephrotoxicity. The results showed that ONP relieved the inflammatory response of RAW264.7 macrophages by increasing the expression level of anti‐inflammatory factor IL‐10. Furthermore, ONP treatment significantly prolonged the survival of the mice treated by cisplatin through decelerating pathological progress and alleviating damaged functions of the kidneys. Compared with the cisplatin group, ONP reduced the oxidative stress of the renal cells and the expression levels of pro‐inflammatory factors. Apoptosis of renal cells was also weakened in the ONP treatment group. These findings indicated that ONP alleviated cisplatin nephrotoxicity mainly by inhibiting oxidative stress, inflammation, and apoptosis in the kidneys, underscoring the potential of ONP supplementation to alleviate the side effects of cisplatin chemotherapy.

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Systematic review and meta-analysis of the efficacy of clinically tested protectants of cisplatin nephrotoxicity

Cited by 36 publications

References 55 publications

A Micellar Formulation of Quercetin Prevents Cisplatin Nephrotoxicity

A Micellar Formulation of Quercetin Prevents Cisplatin Nephrotoxicity

Lansoprazole promotes cisplatin‐induced acute kidney injury via enhancing tubular necroptosis

A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin‐induced nephrotoxicity

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