Systematic review and meta-analysis of the association between diabetes mellitus and incidence and mortality in breast and colorectal cancer

Bruijn, Kirstin Marie Jeanne de; Arends, Lidia R.; Hansen, Bettina E.; Leeflang, Stephanie; Ruiter, Rikje; Eijck, Casper H.J. van

doi:10.1002/bjs.9229

Cited by 184 publications

(163 citation statements)

References 51 publications

(114 reference statements)

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“…Studies have shown there would be a strong association between diabetes and cancer (6). The use of metformin might lead to reduction of liver cancer, pancreas cancer, colon cancer, and breast cancer incidence.…”

Section: Contextmentioning

confidence: 99%

Metformin Versus Sulfonylurea in Breast Cancer Risk of Diabetic Patients: A Systematic Review and Meta-Analysis

et al. 2016

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Context: Metformin has been used for diabetic patients. This medicine might decrease the risk of breast cancer. The main objective of this article was to determine the breast cancer risk in diabetic patients and its association with metformin and sulfonylurea.Evidence Acquisition: In order to gather evidences, main databases [MEDLINE, PubMed, Cochrane library, Science Direct, Trip, Google Scholar, Institute of Scientific Information (ISI), SCOPUS and EMBASE] as well as relevant websites have searched without time limitation up to June 2015. We have searched with appropriate keywords and strategies. After quality assessment of studies, consequences of risk and mortality for breast cancer have extracted. RevMan and comprehensive meta-analysis software has used, if needed, for meta-analysis.Results: A total of 423 studies, 352 studies have entered firstly and 11 studies have selected after final review. According to the significance of heterogeneity (I 2 = 94%) in these studies, meta-analysis have scrutinized by step by step removing the studies to investigate the reason of heterogeneity. So the relative risk of breast cancer was significant in favor of metformin (RR: 0.63, 95% CI (0.56 -0.70), Pv < 0.001). Conclusions:In this study, we have concluded that the incidence of breast cancer in patients with type 2 diabetes who have used metformin might be less than who have used sulfonylurea. However, this finding should consider carefully and needed to be confirmed with further studies.Keywords: Breast Cancer, Diabetes, Metformin, Sulfonylurea, Systematic Review, Meta-Analysis ContextAccording to global statistics, breast cancer has known as the most common cancer in women around the world (1). It has reported as the most common cancer and the second leading cause of cancer deaths among Iranians women (2). Breast cancer was also the most frequent cancer among Iranian women with incidence rate of 25 per 100,000 (3). Diabetes, metabolic syndrome and breast cancer were the main problems in developed and developing countries based on people lifestyle (4). The results of a study aimed at investigating the diabetes impact on breast cancer risk, reported that, 40% of deaths in the first 5 years after breast cancer have occurred in women with diabetes (5).Studies have shown there would be a strong association between diabetes and cancer (6). The use of metformin might lead to reduction of liver cancer, pancreas cancer, colon cancer, and breast cancer incidence. It could also reduce the deaths from liver and breast cancer (7). Metformin, as a drug for treatment of diabetes, has approved in Britain at 1958, 1972 in Canada and 1995. It has also considered as the only biguanide for type 2 diabetic patients with the lowest risk of side effects (9). Metformin was one of the most common anti-diabetic medicines which plenty evidences have suggested its potential impacts as an anti-cancer drug (10).In this regard, results have shown that women with diabetes with long-term use of metformin were less prone to breast cancer. Of c...

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Section: Contextmentioning

confidence: 99%

Metformin Versus Sulfonylurea in Breast Cancer Risk of Diabetic Patients: A Systematic Review and Meta-Analysis

et al. 2016

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“…In Canada, close to 24,000 new cases of crc were expected to be diagnosed in 2013 2 . A statistically significant association between diabetes and the incidence of crc is well established 3,4 . Compared with nondiabetic patients, patients with type 2 diabetes tend to be younger at presentation, to have more right-sided tumours, and to experience poorer 5-year overall survival (os) 5 .…”

Section: Introductionmentioning

confidence: 96%

A Retrospective Study on the Role of Diabetes and Metformin in Colorectal Cancer Disease Survival

et al. 2016

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“…91 For example, patients with diabetes have a 26% increased risk of developing colon cancer and a 30% increased risk of dying because of it compared with patients without diabetes. 92 Data exist that modifiable lifestyle issues (diet and activity) are increasingly associated with the risk of colorectal cancer development, perhaps more so than any other malignancy.…”

Section: Colorectal Cancermentioning

confidence: 99%

Lifestyle Medicine: A Brief Review of Its Dramatic Impact on Health and Survival

Bodai¹,

Nakata²,

Wong

et al. 2018

TPJ

135

106

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By ignoring the root causes of disease and neglecting to prioritize lifestyle measures for prevention, the medical community is placing people at harm. Advanced nations, influenced by a Western lifestyle, are in the midst of a health crisis, resulting largely from poor lifestyle choices. Epidemiologic, ecologic, and interventional studies have repeatedly indicated that most chronic illnesses, including cardiovascular disease, cancer, and type 2 diabetes, are the result of lifestyles fueled by poor nutrition and physical inactivity.In this article, we describe the practice of lifestyle medicine and its powerful effect on these modern instigators of premature disability and death. We address the economic benefits of prevention-based lifestyle medicine and its effect on our health care system: A system on the verge of bankruptcy. We recommend vital changes to a disastrous course. Many deaths and many causes of pain, suffering, and disability could be circumvented if the medical community could effectively implement and share the power of healthy lifestyle choices. We believe that lifestyle medicine should become the primary approach to the management of chronic conditions and, more importantly, their prevention. For future generations, for our own health, and for the Hippocratic Oath we swore to uphold ("First do no harm"), the medical community must take action. It is our hope that the information presented will inspire our colleagues to pursue lifestyle medicine research and incorporate such practices into their daily care of patients. The time to make this change is now.

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Systematic review and meta-analysis of the association between diabetes mellitus and incidence and mortality in breast and colorectal cancer

Abstract: This meta-analysis indicated that DM is a risk factor for breast and colorectal cancer, and for cancer-specific mortality.

Cited by 184 publications

References 51 publications

Metformin Versus Sulfonylurea in Breast Cancer Risk of Diabetic Patients: A Systematic Review and Meta-Analysis

Metformin Versus Sulfonylurea in Breast Cancer Risk of Diabetic Patients: A Systematic Review and Meta-Analysis

A Retrospective Study on the Role of Diabetes and Metformin in Colorectal Cancer Disease Survival

Lifestyle Medicine: A Brief Review of Its Dramatic Impact on Health and Survival

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