Systematic review and meta-analysis of the effectiveness of radiofrequency ablation in low grade dysplastic Barrett’s esophagus

Pandey, Gargi; Mulla, Mubashir; Lewis, Wyn G.; Foliaki, Antonio; Chan, David

doi:10.1055/a-0588-5151

Cited by 24 publications

(18 citation statements)

References 31 publications

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“…Three systematic reviews [58,71,72] Fewer patients progressed to higher grades of dysplasia with the radiofrequency ablation (RFA) treatment [low certainty] [58]. However, there is discrepancy in how this outcome is labelled in the review.…”

Section: Radiofrequency Ablation + Proton Pump Inhibitor Versus Ppi Amentioning

confidence: 99%

“…The text says there was no data for those progressing from IM to dysplasia and labels it as progression to higher grades of dysplasia, but the forest plot is titled progression from IM to dysplasia. When the outcome was restricted to progression to HGD among patients with LGD, no difference was observed [very low certainty] [71,72].…”

Section: Radiofrequency Ablation + Proton Pump Inhibitor Versus Ppi Amentioning

confidence: 99%

“…81 There was no difference between treatment effects for stricture formatio [58] [very low certainty]. There were no instances of perforation reported [72] [very low certainty], and only one study participant developed bleeding, but data was not presented per arm [72] [very low certainty].…”

Section: Radiofrequency Ablation + Proton Pump Inhibitor Versus Ppi Amentioning

confidence: 99%

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Screening for esophageal adenocarcinoma and precancerous conditions (dysplasia and Barrett’s esophagus) in patients with chronic gastroesophageal reflux disease with or without other risk factors: two systematic reviews and one overview of reviews to inform a guideline of the Canadian Task Force on Preventive Health Care (CTFPHC)

et al. 2020

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Background: Two reviews and an overview were produced for the Canadian Task Force on Preventive Health Care guideline on screening for esophageal adenocarcinoma in patients with chronic gastroesophageal reflux disease (GERD) without alarm symptoms. The goal was to systematically review three key questions (KQs): (1) The effectiveness of screening for these conditions; (2) How adults with chronic GERD weigh the benefits and harms of screening, and what factors contribute to their preferences and decision to undergo screening; and (3) Treatment options for Barrett's esophagus (BE), dysplasia or stage 1 EAC (overview of reviews). Methods: Bibliographic databases (e.g. Ovid MEDLINE®) were searched for each review in October 2018. We also searched for unpublished literature (e.g. relevant websites). The liberal accelerated approach was used for title and abstract screening. Two reviewers independently screened full-text articles. Data extraction and risk of bias assessments were completed by one reviewer and verified by another reviewer (KQ1 and 2). Quality assessments were completed by two reviewers independently in duplicate (KQ3). Disagreements were resolved through discussion. We used various risk of bias tools suitable for study design. The GRADE framework was used for rating the certainty of the evidence.

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Section: Radiofrequency Ablation + Proton Pump Inhibitor Versus Ppi Amentioning

confidence: 99%

Section: Radiofrequency Ablation + Proton Pump Inhibitor Versus Ppi Amentioning

confidence: 99%

See 1 more Smart Citation

Screening for esophageal adenocarcinoma and precancerous conditions (dysplasia and Barrett’s esophagus) in patients with chronic gastroesophageal reflux disease with or without other risk factors: two systematic reviews and one overview of reviews to inform a guideline of the Canadian Task Force on Preventive Health Care (CTFPHC)

et al. 2020

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“…Egy másik metaanalízis a radiofrekvenciás abláció (RFA) hatékonyságát vizsgálta Barrett-nyelőcsőben (4). A guideline jelenleg az endoszkópos ablációt akkor ajánlja, ha a lowgrade dysplasia (LGD) 6 hónap követés során perzisztál.…”

Section: öSszefoglaló Közlemények / Reviewsunclassified

Újdonságok a tápcsatorna endoszkópiájában

Bajor¹,

Dubravcsik²,

Hritz³

et al. 2019

CEU-JGH

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“…Наиболее эффективным методом является радиочастотная аблация, применение которой позволяет добиваться удаления дисплазии у 96,7% пациентов при наблюдении в течение 12-44 мес. и значительно снижать показатели прогрессирования пищевода Барретта в рак пищевода [22].…”

Section: заболевания пищевода и желудкаunclassified

Prevalence and modern aspects of the treatment of patients with Barrett’s esophagus

et al. 2018

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The article analyzes the prevalence and principles in treatment of Barrett’s esophagus. The prevalence of Barrett’s esophagus varies widely from region to region of the world and has ethnic differences. The use of endoscopic methods and the histological examination of the biopsies of esophageal mucosa are of utmost importance in the diagnosis of this pathology. The prevention of esophageal cancer is the main task in managing patients with Barrett’s esophagus. The length of the Barrett’s esophagus segment, the presence and extent of dysplasia is of the greatest importance to select tactics for managing patients. Endoscopic methods are widely used for the eradication of metaplasia sites, among which the radiofrequency ablation is the most effective one. Prolonged treatment with proton pump inhibitors is safe and reduces the risk of transformation of Barrett’s esophagus into adenocarcinoma of the esophagus. There is evidence that small doses of aspirin, nonsteroidal anti-inflammatory drugs, statins and ursodeoxycholic acid have the preventive effect on the development of esophageal cancer. However, the possibilities of using these drugs for this purpose are still limited. Anti-reflux surgery still holds relevance, but at the same time, it has no advantages over the drug therapy for the prevention of esophageal cancer.

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Systematic review and meta-analysis of the effectiveness of radiofrequency ablation in low grade dysplastic Barrett’s esophagus

Abstract: RFA safely eradicates IM and dysplasia and reduces the rates of progression from LGD to HGD or cancer in the short term.

Cited by 24 publications

References 31 publications

Újdonságok a tápcsatorna endoszkópiájában

Prevalence and modern aspects of the treatment of patients with Barrett’s esophagus

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