Systematic review and meta-analysis of prevalence and risk factors for Barrett’s esophagus

Qumseya, Bashar J.; Bukannan, Aymen; Gendy, Sherif; Ahemd, Yahya; Sultan, Shahnaz; Bain, Paul; Gross, Seth A.; Iyer, Prasad G.; Wani, Sachin

doi:10.1016/j.gie.2019.05.030

Cited by 103 publications

(91 citation statements)

References 69 publications

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“…To the best of our knowledge this is the first study to systematically provide an overall estimate of the prevalence of endoscopically suspected and histologically confirmed gastro-oesophageal reflux symptoms. [12] The authors pooled data from 13 studies in which reflux symptoms were reported as a risk factor, reporting a pooled prevalence of BO of 3%…”

Section: Discussionmentioning

confidence: 99%

“…[11] A more recent systematic review and meta-analysis reported a pooled prevalence of BO of 3% among subjects in the general population with gastro-oesophageal reflux symptoms. [12] However, other than the studies included in their analysis, which described the prevalence of BO in unselected samples of the general population, a considerable amount of data from other settings, such as cohorts of only individuals with GORD, has been published examining the relationship between BO and gastro-oesophageal reflux symptoms specifically. We therefore performed a systematic review and meta-analysis of the prevalence of BO, and its complications, among patients with gastro-oesophageal reflux symptoms, or GORD, in order to examine these issues.…”

Section: What Are the New Findings?mentioning

confidence: 99%

See 1 more Smart Citation

Global prevalence of Barrett’s oesophagus and oesophageal cancer in individuals with gastro-oesophageal reflux: a systematic review and meta-analysis

Eusebi

Cirota

Zagari

et al. 2020

Gut

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ObjectivesChronic gastro-oesophageal reflux might lead to the development of Barrett’s oesophagus (BO) or even oesophageal adenocarcinoma. There has been no definitive systematic review and meta-analysis of data to estimate global prevalence of BO or oesophageal adenocarcinoma in individuals with gastro-oesophageal reflux.DesignWe searched MEDLINE, Embase and Embase Classic to identify cross-sectional surveys that reported prevalence of BO or oesophageal adenocarcinoma in adults with gastro-oesophageal reflux. We extracted prevalence for all studies, both for endoscopically suspected and histologically confirmed cases. We calculated pooled prevalence according to study location, symptom frequency and sex, as well as ORs with 95% CIs.ResultsOf the 4963 citations evaluated, 44 reported prevalence of endoscopically suspected and/or histologically confirmed BO. Prevalence of BO among individuals with gastro-oesophageal reflux varied according to different geographical regions ranging from 3% to 14% for histologically confirmed BO with a pooled prevalence of 7.2% (95% CI 5.4% to 9.3%), whereas pooled prevalence for endoscopically suspected BO was 12.0% (95% CI 5.5% to 20.3%). There was heterogeneity in many of our analyses. Prevalence of BO was significantly higher in men, both for endoscopically suspected (OR=2.1; 95% CI 1.6 to 2.8) and histologically confirmed BO (OR=2.3; 95% CI 1.7 to 3.2). Dysplasia was present in 13.9% (95% CI 8.9% to 19.8%) of cases of histologically confirmed BO, 80.7% of which was low-grade.ConclusionThe prevalence of Barrett’s oesophagus among individuals with gastro-oesophageal reflux varied strikingly among countries, broadly resembling the geographical distribution of gastro-oesophageal reflux itself. Prevalence of BO was significantly higher in men.

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Section: Discussionmentioning

confidence: 99%

Section: What Are the New Findings?mentioning

confidence: 99%

Global prevalence of Barrett’s oesophagus and oesophageal cancer in individuals with gastro-oesophageal reflux: a systematic review and meta-analysis

Eusebi

Cirota

Zagari

et al. 2020

Gut

View full text Add to dashboard Cite

show abstract

“…In a more recent SR and MA by Qumseya et al, 51 the authors estimated the prevalence of BE in patients with specific risk factors who underwent screening and tried to synthesize the interactions between such risk factors. The authors identified 48 studies with over 300,000 patients, of which >1900 had biopsy specimenconfirmed BE.…”

Section: Policymakersmentioning

confidence: 99%

ASGE guideline on screening and surveillance of Barrett’s esophagus

Qumseya¹,

Sultan

Bain

et al. 2019

Gastrointestinal Endoscopy

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298

204

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“…Barrett's esophagus (BE) or intestinal metaplasia of the esophagus is a precursor lesion for EAC, and progression to EAC involves a series of pathologic changes from nondysplastic BE to low-grade dysplasia, high-grade dysplasia, and finally EAC. The incidence of BE and EAC increases with age, especially after age 50, and occurs more commonly among men and smokers with prolonged GERD, obesity, or family history of BE (Qumseya et al 2019). Screening for BE is still controversial, as over 90% of patients with EAC do not have a prior diagnosis of BE, but one time endoscopic screening for BE is recommended by society guidelines in high-risk individuals with several risk factors (Shaheen et al 2016).…”

Section: Barrett's Esophagus and Esophageal Cancermentioning

confidence: 99%