Systematic review and meta-analysis of outcomes after liver resection in patients with hepatocellular carcinoma (HCC) with and without bile duct thrombus

Navadgi, Suresh; Chang, Chi Chun; Bartlett, Adam; McCall, John L.; Pandanaboyana, Sanjay

doi:10.1016/j.hpb.2015.12.003

Cited by 47 publications

(31 citation statements)

References 28 publications

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“…The reasons for the poor prognosis of HCC patients with bile duct invasion include the following. HCC with bile duct invasion is often accompanied by obstructive jaundice, cholangitis and hemobilia that are also immediate threats to survival, HCC with bile duct invasion is frequently accompanied by portal vein invasion, while HCC with bile duct invasion has been shown to have a more advanced tumor stage HCC with adverse histological features including higher rates of microvascular invasion, lymphovascular invasion and poor differentiation [65]. The long-term outcomes after surgical treatment for HCC with bile duct invasion are still controversial.…”

Section: Bile Duct Invasionmentioning

confidence: 99%

Current status of imaging biomarkers predicting the biological nature of hepatocellular carcinoma

et al. 2019

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Hepatocellular carcinoma (HCC) is heterogeneous in terms of its biological nature. Various factors related to its biological nature, including size, multifocality, macroscopic morphology, grade of differentiation, macro/microvascular invasion, bile duct invasion, intra-tumoral fat and molecular factors, and their value as prognostic imaging biomarkers have been reported. And recently, genome-based molecular HCC classification correlated with clinical outcome has been elucidated. The imaging biomarkers suggesting a less aggressive nature of HCC are smaller size, solitary tumor, smooth margin suggesting small nodular type with indistinct margin and simple nodular type with distinct margin, capsule, imaging biomarkers predicting early or well-differentiated grade, intra-tumoral fat detection, and low fluorodeoxyglucose (FDG) accumulation. The imaging biomarkers suggesting an aggressive HCC nature are larger size, multifocality, non-smooth margin suggesting simple nodular type with extranodular growth, confluent multinodular, and infiltrative type, imaging biomarkers predicting poor differentiation, macrovascular tumor thrombus, predicting microvascular invasion imaging biomarkers, bile duct dilatation or tumor thrombus, and high FDG accumulation. In the genome-based molecular classification, CTNNB-1 mutated HCC shows a less aggressive nature, while CK19/EpCAM positive HCC and macrotrabecular massive HCC show an aggressive one. Better understanding of these imaging biomarkers can contribute to devising more appropriate treatment plans for HCC.

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Section: Bile Duct Invasionmentioning

confidence: 99%

Current status of imaging biomarkers predicting the biological nature of hepatocellular carcinoma

et al. 2019

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“…Liver resection in these patients offers similar survival at 3 years but inferior long-term survival compared with those patients without bile duct tumour thrombus. 28 In our opinion, the mere presence of bile duct tumour thrombus in HCC does not indicate an advanced or inoperable lesion. When technically feasible, a formal liver resection is the preferred treatment option for these patients.…”

Section: Discussionmentioning

confidence: 62%

Liver resection for hepatocellular carcinoma: personal experiences in a series of 1330 consecutive cases in China

Huang

Yan

et al. 2018

ANZ Journal of Surgery

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“…Portal veins are located near the bile ducts. To this end, HCC patients with a bile duct thrombus display differential progression of HCC, including a higher rate of lymphovascular invasion, macrovascular invasion, and poor differentiation [ 33 ].…”

Section: Disordered Liver Zonation Points To Abnormal Metabolism Amentioning

confidence: 99%

In Search of Zonation Markers to Identify Liver Functional Disorders

Yang

Zhang

et al. 2020

Oxidative Medicine and Cellular Longevity

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A substantial amount of research is being conducted on zonation markers to identify hepatic injuries and disorders based on the structural and functional zonation of the liver. In contrast to metabolic zonation, hepatocyte ploidy reflects the capability of liver regenerative turnover. Nonetheless, many knowledge gaps remain in the understanding of the links between liver disorders and altered zonation and ploidy, partially owing to the lack of sufficient zonation markers. Under this setting, we recapitulated the currently known and prospective markers used to identify normal and altered liver zonation in different disorders. Furthermore, we discussed new findings from studies that have used advanced methodologies to identify potential markers with greater accuracy. We also elaborated on the perspectives and future applications of zonation research in the early detection of various liver diseases.

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Systematic review and meta-analysis of outcomes after liver resection in patients with hepatocellular carcinoma (HCC) with and without bile duct thrombus

Cited by 47 publications

References 28 publications

Current status of imaging biomarkers predicting the biological nature of hepatocellular carcinoma

Current status of imaging biomarkers predicting the biological nature of hepatocellular carcinoma

Liver resection for hepatocellular carcinoma: personal experiences in a series of 1330 consecutive cases in China

In Search of Zonation Markers to Identify Liver Functional Disorders

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