Systematic Review and Meta-analysis of Current Experience in Treating IPNB

Abstract

Early surgery is advisable for radiologically suspected IPNB as it is frequently invasive. The pathobiology of IPNB demonstrates geographic variation. Pancreaticobiliary IPNB expresses MUC1 and is more frequently associated with invasive disease than other IPNB subtypes.

Intraductal papillary neoplasm of the bile duct found incidentally during examination of colonic disease: A case report

“…IPNB accounts for 7%-38% of all bile duct carcinomas, and 40%-80% of IPNBs contain invasive carcinomas [3,6]. However, IPNB is generally less invasive and has a more favorable outcome than conventional bile duct cholangiocarcinoma.…”

“…The intrahepatic bile ducts showed no changes such as dilatation on preoperative images. Previous reports have indicated that most IPNB patients present with right hypochondria (35-88.5%), recurrent acute cholangitis (5-59%), and obstructive jaundice (20-36%) [4-6]), but that IPNB may also be detected incidentally in asymptomatic individuals (5-12%) [3,4]. IPNB remains difficult to differentiate from cholangiocarcinoma and other types of bile duct disease, and may mimic colon cancer metastases on radiological findings [7].…”

“…The clinical manifestations of IPNB include obstructive jaundice and cholangitis, but IPNB can also be detected incidentally in asymptomatic individuals. Early surgery should be performed in all cases of suspected IPNB based on clinical findings and imaging alone, to prevent disease progression [3]. We experienced a surgical case of IPNB detected during close examination of colonic disease.…”

“…Early systems classified bile duct tumors on the basis of their ability to produce mucin. IPNB is identified as a premalignant lesion or intraepithelial neoplasm of the bile duct, and has also been described anecdotally as having limited invasive potential, typically involving only cellular atypia, and at most carcinoma in situ [2,3]. However, tumors eventually invade into the bile duct wall and progress to invasive cholangiocarcinoma.…”

Clinicopathological Aspects and Diagnostic Problems in Patients with Intraductal Papillary Neoplasm of the Bile Duct

“…Furthermore, three types of pre-invasive lesion of bile duct tumor were also indicated in the sixth edition of the General Rules for Clinical and Pathological Studies on Cancer of the Biliary Tract in 2013 as follows: i) biliary intraepithelial neoplasm, ii) IPNB or intracystic papillary neoplasm, and iii) mucinous cystic neoplasm (17). IPNB-originating advanced bile duct carcinoma has also been reported (18,19). However, the definitive similarity and differentiation between IPNB and associated biliary neoplasms may still be unclear in some cases.…”