Systematic review and meta-analysis of the association between peripheral inflammatory cytokines and generalised anxiety disorder

Costello, Harry; Gould, Rebecca L.; Abrol, Esha; Howard, Robert

doi:10.1136/bmjopen-2018-027925

Cited by 149 publications

(111 citation statements)

References 58 publications

Supporting

Mentioning

104

Contrasting

Order By: Relevance

“…Elevated cytokines are related to decreased levels of serotonin, which may result in depression and cognitive dysfunction (Sohani and Samaan, 2012). While it appears anxiety is related to an elevated inflammatory response in healthy individuals, there is less evidence of cytokines playing a role (Costello et al, 2019). However, higher anxiety is associated with inflammatory markers in patients with diabetes (Brennan et al, 2009), and inflammation during acute coronary syndrome has been shown to predict anxiety and cognitive symptoms of depression (Steptoe et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Psychological Distress and Cognitive Function Differs as a Function of Obesity Status in Inpatient Heart Failure

et al. 2020

View full text Add to dashboard Cite

Heart failure (HF) is a chronic medical condition rapidly growing in prevalence. Evidence links HF to cognitive decline, obesity, and psychological distress. The current study examined the association between cognitive function and ejection fraction (EF%), anxiety, depression, and obesity in inpatient HF. Patients completed the Generalized Anxiety Disorder 7-Item Scale (GAD-7), Patient Health Questionnaire 9-Item Scale (PHQ-9), and Mini-Cog while hospitalized for HF. Additional demographic and medical information was gathered via chart review. All models controlled for age. Of 117 patients assessed (49% male), 55% (n = 64) were obese. ANCOVA analyses were conducted comparing those with obesity and without on cognitive function: model A included EF%, model B included depression, and model C included anxiety. All three models were significantly related to cognitive function. There was a significant interaction effect of EF% and obesity and of anxiety and obesity to predict Mini-Cog scores. Post hoc partial correlational analyses revealed that anxiety was negatively associated with Mini-Cog scores among only patients without obesity. Depression was not significantly related to cognitive function in either group. However, patients with obesity demonstrated higher depression and anxiety than patients without. Results suggest that at lower EF%, and with higher anxiety, patients without obesity may be at greater risk of cognitive dysfunction than those with obesity. Cognitive dysfunction among HF patients with obesity may be independent of psychological distress. These findings may reflect the "obesity paradox" observed among HF patients, in that patients with obesity may have a different biopsychosocial presentation, which may lead to unexpected clinical outcomes. Further research is necessary to articulate the relationship of obesity and cognitive function in HF.

show abstract

Section: Discussionmentioning

confidence: 99%

Relationship Between Psychological Distress and Cognitive Function Differs as a Function of Obesity Status in Inpatient Heart Failure

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Similar basal anti-inflammatory effect was observed before by antiepileptic drugs that inhibits neuronal sodium channels like vinpocetine, carbamazepine and lamotrigine 30,50 . This basal inhibition might be clinically relevant to the current PGB-indicated conditions where elevated basal levels of these cytokines were clinically observed [7][8][9][10][11][12][13][14][15][16][17] .…”

Section: Discussionmentioning

confidence: 76%

“…Of note, in the current report we have focused on the effects of PGB on peripheral inflammatory responses. Although neuroinflammation per se was not investigated in this study, our results might give some clues to the effect of PGB on peripheral inflammation observed in PGB-indicated conditions (neuropathic pain conditions, fibromyalgia, epilepsy and generalized anxiety disorders) where inflammatory mechanisms and elevation of proinflammatory cytokines, such as IL-6, TNF-α, IL-1β and IL-2 have been documented [7][8][9][10][11]16,17 . Besides, compared to our study, similar model of inflammation and comparable doses of LPS were employed before to study these conditions [21][22][23][24] .…”

Section: Discussionmentioning

confidence: 79%

“…Peripheral inflammation is observed in the primary PGB-indicated conditions which all share elevated levels of IL-6, TNF-α, IL-1β and IL-2 cytokines [7][8][9][10][11][12][13][14][15][16][17] . Mitogen (LPS or ConA)-induced models of inflammation has long been used to assess the effects of drugs on macrophages-and T-cells-mediated proinflammatory cytokines production 34 and were also used to study the inflammation in PGB-indicated conditions [21][22][23][24]26 .…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, elevated levels of the proinflammatory cytokines IL-6, TNF-α, IL-1β and IL-2 have been reported in epilepsy [12][13][14][15][16] . In patients with generalized anxiety disorders, an elevated level of several proinflammatory cytokines, including IL-6, TNF-α, IL-1β and IL-2 have been reported 17 . Thus, peripheral inflammation PGB preparation.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Pregabalin inhibits in vivo and in vitro cytokine secretion and attenuates spleen inflammation in Lipopolysaccharide/Concanavalin A -induced murine models of inflammation

Abu-rish

Mansour

et al. 2020

Sci Rep

View full text Add to dashboard Cite

is observed in the principal PGB-indicated conditions which share the alteration in IL-6, TNF-α, IL-2 and IL-1β cytokines level. Yet, reports on PGB immunomodulatory and anti-inflammatory effects are a few and focused mainly on in vitro assays, local inflammatory changes within the nervous system, and attenuation of the secretion of only IL-1β and TNF-α cytokines 18-20. In addition, PGB effects on cytokines secretion in immune cells, such as isolated splenocytes and peritoneal macrophages (PMs), and its effect on lymphoid organs, were not examined before. Therefore, there is a need to perform a simultaneous assessment of the effect of PGB on the secretion of the cytokines that were commonly elevated in the aforementioned PGB-indicated conditions (IL-6, TNF-α, IL-1β and IL-2) and to expand the investigation to its effect on lymphoid organs and cytokine secretion in immune cells. As peripheral inflammation and elevated systemic cytokines levels were demonstrated in the above-mentioned PGB-indicated conditions, we investigated in this study the effect of PGB on murine models of peripheral inflammation. In this study, we used for the first time, LPS and ConA-induced murine models of inflammation to examine the effect of PGB on peripheral proinflammatory cytokine secretion (IL-6, TNF-α, IL-1β and IL-2) in vitro and in vivo in BALB/c mice. LPS-model of inflammation has been employed before to study neuroinflammatory conditions, seizure and anxiety disorders in mice 21-25 , while ConA was used to investigate T-cell function in patients with fibromyalgia 26. Additionally, in this study, the effect of PGB on mitogen-induced inflammatory changes in the spleen, as a lymphoid organ, was also examined for the first time. Regarding in vitro investigation, the lack of reports that examined the effect of PGB on the secretion of cytokines in immune cells prompted us to investigate such effects of PGB on basal and mitogen-induced proinflammatory cytokines secretion in splenocytes and peritoneal macrophages (PMs).

show abstract

Association Between Mental Health Disorders and Mortality Among Patients With COVID-19 in 7 Countries

et al. 2021

View full text Add to dashboard Cite

IMPORTANCE Heterogeneous evidence exists for the association between COVID-19 and the clinical outcomes of patients with mental health disorders. It remains unknown whether patients with COVID-19 and mental health disorders are at increased risk of mortality and should thus be targeted as a high-risk population for severe forms of COVID-19.OBJECTIVE To determine whether patients with mental health disorders were at increased risk of COVID-19 mortality compared with patients without mental health disorders.DATA SOURCES For this systematic review and meta-analysis, MEDLINE, Web of Science, and Google Scholar were searched from inception to February 12, 2021. Bibliographies were also searched, and the corresponding authors were directly contacted. The search paradigm was based on the following combination: (mental, major[MeSH terms]) AND (COVID-19 mortality[MeSH terms]). To ensure exhaustivity, the term mental was replaced by psychiatric, schizophrenia, psychotic, bipolar disorder, mood disorders, major depressive disorder, anxiety disorder, personality disorder, eating disorder, alcohol abuse, alcohol misuse, substance abuse, and substance misuse.STUDY SELECTION Eligible studies were population-based cohort studies of all patients with identified COVID-19 exploring the association between mental health disorders and mortality.DATA EXTRACTION AND SYNTHESIS Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline was used for abstracting data and assessing data quality and validity. This systematic review is registered with PROSPERO. MAIN OUTCOMES AND MEASURESPooled crude and adjusted odds ratios (ORs) for the association of mental health disorders with mortality were calculated using a 3-level random-effects (study/country) approach with a hierarchical structure to assess effect size dependency.RESULTS In total, 16 population-based cohort studies (data from medico-administrative health or electronic/medical records databases) across 7 countries (1 from Denmark, 2 from France, 1 from Israel, 3 from South Korea, 1 from Spain, 1 from the UK, and 7 from the US) and 19 086 patients with mental health disorders were included. The studies covered December 2019 to July 2020, were of good quality, and no publication bias was identified. COVID-19 mortality was associated with an increased risk among patients with mental health disorders compared with patients without mental health disorders according to both pooled crude OR (1.75 [95% CI, 1.40-2.20]; P<.05) and adjusted OR (1.38 [95% CI, 1.15-1.65]; P<.05). The patients with severe mental health disorders had the highest ORs for risk of mortality (crude OR: 2.26 [95% CI, 1.18-4.31]; adjusted OR: 1.67 [95% CI, 1.02-2.73]). CONCLUSIONS AND RELEVANCEIn this systematic review and meta-analysis of 16 observational studies in 7 countries, mental health disorders were associated with increased COVID-19-related mortality. Thus, patients with mental health disorders should have been targeted as a high-risk population for severe forms of COVID-19,...

show abstract

Systematic review and meta-analysis of the association between peripheral inflammatory cytokines and generalised anxiety disorder

Cited by 149 publications

References 58 publications

Relationship Between Psychological Distress and Cognitive Function Differs as a Function of Obesity Status in Inpatient Heart Failure

Relationship Between Psychological Distress and Cognitive Function Differs as a Function of Obesity Status in Inpatient Heart Failure

Pregabalin inhibits in vivo and in vitro cytokine secretion and attenuates spleen inflammation in Lipopolysaccharide/Concanavalin A -induced murine models of inflammation

Association Between Mental Health Disorders and Mortality Among Patients With COVID-19 in 7 Countries

Contact Info

Product

Resources

About