Systematic review and meta-analysis of the efficacy of different exercise programs in pilocarpine induced status epilepticus models

Iqbal, Muneeb; Rahman, Md. Saidur; Zafar, Salman; Chen, Xinlin; Liu, Jianxin; Liu, Yong

doi:10.1016/j.yebeh.2017.06.007

Cited by 12 publications

(4 citation statements)

References 66 publications

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“…As the main finding, the authors pointed out that resistance training proved to be more effective in treating epilepsy in rats, and protocols of long duration and moderate to high intensity were demonstrated to be more effective when compared with their counterparts. 10 A previous study reported that only 2 of the 400 adults (less than 0.5%) had seizures during physical activity. 11 Another study concluded that exercise and sports may not trigger seizures in children and adolescents with epilepsy during physical activity at school.…”

Section: Introductionmentioning

confidence: 96%

The Benefits of Physical Activity in Children and Adolescents with Epilepsy: A Systematic Review

Svierkovski

Stein

Cavazzotto

et al. 2021

Journal of Pediatric Epilepsy

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The aim of this study was to review the literature about the effect of physical activity intervention in children and adolescents with epilepsy. Articles were searched in the central electronic databases of MEDLINE, Embase, PsycAriticles, and CINAHL for the following keywords: “epilepsy,” “seizure,” “physical activity,” “physical exercise,” “exercise therapy,” “sport,” using the Boolean operator “AND” and “OR.” The quality of the selected articles was evaluated by the Physiotherapy Evidence Database scale. Out of the 22 articles selected, 18 did not involve intervention or did not have pre- and postresults and therefore were excluded from the study. The remaining four were studies from Canada and Korea which comprised two long-period interventions and were included in the analysis. Both programs demonstrated a positive effect of physical activity on variables related to psychological well-being and cognitive function. All the four articles demonstrated a lower score of quality. In conclusion, reviewed studies suggest that physical exercise program induces some benefits in children and adolescents with epilepsy. However, the noncontrolled trials and the varied analyses (quantitative vs. qualitative) make it difficult to establish a consensus about benefits of physical activity in epilepsy.

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Section: Introductionmentioning

confidence: 96%

The Benefits of Physical Activity in Children and Adolescents with Epilepsy: A Systematic Review

Svierkovski

Stein

Cavazzotto

et al. 2021

Journal of Pediatric Epilepsy

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“…Moreover, forced PE seemed to produce more bromodeoxyuridine+ cells, although it increased anxiety-like behaviors in the animals (23). For some patients who are unable to perform voluntary PE, researchers first chose mechanically-assisted forced PE (19,(24)(25)(26).…”

Section: Introductionmentioning

confidence: 99%

Aerobic Physical Exercise as a Non-medical Intervention for Brain Dysfunction: State of the Art and Beyond

et al. 2022

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Brain disorders, including stroke, Alzheimer's disease, depression, and chronic pain, are difficult to effectively treat. These major brain disorders have high incidence and mortality rates in the general population, and seriously affect not only the patient's quality of life, but also increases the burden of social medical care. Aerobic physical exercise is considered an effective adjuvant therapy for preventing and treating major brain disorders. Although the underlying regulatory mechanisms are still unknown, systemic processes may be involved. Here, this review aimed to reveal that aerobic physical exercise improved depression and several brain functions, including cognitive functions, and provided chronic pain relief. We concluded that aerobic physical exercise helps to maintain the regulatory mechanisms of brain homeostasis through anti-inflammatory mechanisms and enhanced synaptic plasticity and inhibition of hippocampal atrophy and neuronal apoptosis. In addition, we also discussed the cross-system mechanisms of aerobic exercise in regulating imbalances in brain function, such as the “bone-brain axis.” Furthermore, our findings provide a scientific basis for the clinical application of aerobic physical exercise in the fight against brain disorders.

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“…In this regard, an increasing number of animal studies have demonstrated the impact of exercise in epilepsy and the neurobiological mechanisms of these beneficial effects (4,17). Two systematic reviews and meta-analyses addressed the efficacy of exercise before and after the induction of epilepsy, using the pilocarpine and kainate models of epilepsy (18,19). In their review, the physical exercise program significantly reduced the number of spontaneous recurrent seizures in the pilocarpine and kainate models (18,19).…”

Section: Introductionmentioning

confidence: 99%

“…Two systematic reviews and meta-analyses addressed the efficacy of exercise before and after the induction of epilepsy, using the pilocarpine and kainate models of epilepsy (18,19). In their review, the physical exercise program significantly reduced the number of spontaneous recurrent seizures in the pilocarpine and kainate models (18,19). Physical exercise also exerted a positive influence before pilocarpine and kainate induction by increasing the latency to develop status epilepticus (SE), although not statistically significant in the pilocarpine model.…”

Section: Introductionmentioning

confidence: 99%

The Potential Role of Previous Physical Exercise Program to Reduce Seizure Susceptibility: A Systematic Review and Meta-Analysis of Animal Studies

et al. 2021

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Background: Clinical and pre-clinical studies indicate a reduction in seizure frequency as well as a decrease in susceptibility to subsequently evoked seizures after physical exercise programs. In contrast to the influence of exercise after epilepsy previously established, various studies have been conducted attempting to investigate whether physical activity reduces brain susceptibility to seizures or prevents epilepsy. We report a systematic review and meta-analysis of different animal models that addressed the impact of previous physical exercise programs to reduce seizure susceptibility.Methods: We included animal model (rats and mice) studies before brain insult that reported physical exercise programs compared with other interventions (sham, control, or naïve). We excluded studies that investigated animal models after brain insult, associated with supplement nutrition or drugs, that did not address epilepsy or seizure susceptibility, ex vivo studies, in vitro studies, studies in humans, or in silico studies. Electronic searches were performed in the MEDLINE (PubMed), Web of Science (WOS), Scopus, PsycINFO, Scientific Electronic Library Online (SciELO) databases, and gray literature, without restrictions to the year or language of publication. We used SYRCLE's risk of bias tool and CAMARADES checklist for study quality. We performed a synthesis of results for different types of exercise and susceptibility to seizures by random-effects meta-analysis.Results: Fifteen studies were included in the final analysis (543 animals), 13 of them used male animals, and Wistar rats were the most commonly studied species used in the studies (355 animals). The chemoconvulsants used in the selected studies were pentylenetetrazol, penicillin, kainic acid, pilocarpine, and homocysteine. We assessed the impact of study design characteristics and the reporting of mitigations to reduce the risk of bias. We calculated a standardized mean difference effect size for each comparison and performed a random-effects meta-analysis. The meta-analysis included behavioral analysis (latency to seizure onset, n = 6 and intensity of motor signals, n = 3) and electrophysiological analysis (spikes/min, n = 4, and amplitude, n = 6). The overall effect size observed in physical exercise compared to controls for latency to seizure onset was −130.98 [95% CI: −203.47, −58.49] (seconds) and the intensity of motor signals was −0.40 [95% CI: −1.19, 0.40] (on a scale from 0 to 5). The largest effects were observed in electrophysiological analysis for spikes/min with −26.96 [95% CI: −39.56, −14.36], and for spike amplitude (μV) with −282.64 [95% CI: −466.81, −98.47].Discussion:Limitations of evidence. A higher number of animal models should be employed for analyzing the influence of exerciseon seizure susceptibility. The high heterogeneity in our meta-analysis is attributable to various factors, including the number of animals used in each study and the limited number of similar studies. Interpretation. Studies selected in this systematic review and meta-analysis suggest that previous physical exercise programs can reduce some of the main features related to seizure susceptibility [latency seizure onset, spikes/min, and spike amplitude (μV)] induced by the administration of different chemoconvulsants.Systematic Review Registration: PROSPERO, identifier CRD42021251949; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=251949.

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Systematic review and meta-analysis of the efficacy of different exercise programs in pilocarpine induced status epilepticus models

Cited by 12 publications

References 66 publications

The Benefits of Physical Activity in Children and Adolescents with Epilepsy: A Systematic Review

The Benefits of Physical Activity in Children and Adolescents with Epilepsy: A Systematic Review

Aerobic Physical Exercise as a Non-medical Intervention for Brain Dysfunction: State of the Art and Beyond

The Potential Role of Previous Physical Exercise Program to Reduce Seizure Susceptibility: A Systematic Review and Meta-Analysis of Animal Studies

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