Systematic review and meta-analysis of olfactive stimulation interventions to manage procedural pain in preterm and full-term neonates

Clifford-Faugère, Gwenaëlle De; Lavallée, Andréane; Khadra, Christelle; Ballard, Ariane; Colson, Sébastien; Aita, Marilyn

doi:10.1016/j.ijnurstu.2020.103697

Cited by 15 publications

(24 citation statements)

References 48 publications

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“…These results support not only our hypotheses but also confirm the effects of BMO or BMO + BMTSF on reducing variations in heart rate, SpO 2 , and time to crying cessation. Our study findings echo two meta-analyses on the effects of BMO: one reported that BMO reduced pain [41]; a second reported that BMO affected variations in heart rate, SpO 2 , and crying duration [42]. The results of this study also support reports showing that BM odor has a calming effect, using changes in heart rate and SpO 2 as biological parameters of pain.…”

Section: Discussionsupporting

confidence: 87%

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Efficacy of Breast Milk Olfactory and Gustatory Interventions on Neonates’ Biobehavioral Responses to Pain during Heel Prick Procedures

Lin

Liaw

Chen

et al. 2022

IJERPH

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This study aimed to evaluate the efficacy of breast milk odor either alone or in combination with breast milk taste (via syringe-feeding) to alleviate neonates’ biobehavioral responses to pain during heel-prick procedures. This prospective randomized controlled trial recruited 114 neonates by convenience sampling from a newborn unit of a medical center in Taiwan. Neonates were randomly assigned to three groups: control (gentle touch + human voice), control + breast milk odor, and control + breast milk odor + breast milk taste. Heart rate, oxygen saturation, and voice recordings of crying were measured across heel-prick procedures: baseline, no stimuli (stage 0); during heel prick (Stages 1–4); and recovery (Stages 5–10). Generalized estimating equations and Kaplan–Meier survival analysis compared differences in changes between groups for heart rate, oxygen saturation, and time to crying cessation. Changes in mean heart rate and oxygen saturation in neonates receiving breast milk odor or breast milk odor + breast milk taste were significantly less than those at the corresponding stage for the control group. Among neonates receiving breast milk odor or breast milk odor + breast milk taste, hazard rate ratios for crying cessation were 3.016 and 6.466, respectively. Mother’s breast milk olfactory and gustatory interventions could stabilize the biobehavioral responses to pain during heel prick procedures in neonates.

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Section: Discussionsupporting

confidence: 87%

“…One study found that BMO was more effective when compared with formula odor during the heel-prick procedure [43]. Two studies demonstrated a reduction in pain for preterm infants receiving BMO during venipuncture [27,41].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Breast Milk Olfactory and Gustatory Interventions on Neonates’ Biobehavioral Responses to Pain during Heel Prick Procedures

Lin

Liaw

Chen

et al. 2022

IJERPH

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“…There are contradictory results for aromatherapy by inhalation (e.g., do they provide relief and comfort and reduce stress?) although an extensive body of research exists on clinical procedural pain in infants and its relation with smell [106][107][108][109][110]. Aromatherapy may therefore have an effect on pain intensity modulation and be a useful treatment in clinical practice.…”

Section: Interaction Pain-smell In Pathological Conditionsmentioning

confidence: 99%

Pain, Smell, and Taste in Adults: A Narrative Review of Multisensory Perception and Interaction

et al. 2021

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Every day our sensory systems perceive and integrate a variety of stimuli containing information vital for our survival. Pain acts as a protective warning system, eliciting a response to remove harmful stimuli; it may also be a symptom of an illness or present as a disease itself. There is a growing need for additional pain-relieving therapies involving the multisensory integration of smell and taste in pain modulation, an approach that may provide new strategies for the treatment and management of pain. While pain, smell, and taste share common features and are strongly linked to emotion and cognition, their interaction has been poorly explored. In this review, we provide an overview of the literature on pain modulation by olfactory and gustatory substances. It includes adult human studies investigating measures of pain threshold, tolerance, intensity, and/or unpleasantness. Due to the limited number of studies currently available, we have structured this review as a narrative in which we comment on experimentally induced and clinical pain separately on pain-smell and pain-taste interaction. Inconsistent study findings notwithstanding, pain, smell, and taste seem to interact at both the behavioral and the neural levels. Pain intensity and unpleasantness seem to be affected more by olfactory substances, whereas pain threshold and tolerance are influenced by gustatory substances. Few pilot studies to date have investigated these effects in clinical populations. While the current results are promising for the future, more evidence is needed to elucidate the link between the chemical senses and pain. Doing so has the potential to improve and develop novel options for pain treatment.

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“…Subscale 5 ("massage" and "music") presents a moderate inter-item correlation (0.31) between the 2 items, which translates into an internal consistency of 0.50. This weak internal consistency can be explained by the low number of items composing this subscale, which could be improved by adding new items reflecting emerging evidence-based NICU practices pertaining to sensory stimulation such as the use of white noise ( Ren et al, 2019 ) or artificial smells (lavender, vanilla) ( De Clifford-Faugère et al, 2020 ).…”

Section: Part IIImentioning

confidence: 99%

French Translation, Adaptation, and Initial Validation of the Nurses’ Attitudes and Perceptions of Pain Assessment in Neonatal Intensive Care Questionnaire (NAPPAQ)

Clifford-Faugère

Laporte

Gélinas

et al. 2022

Pain Management Nursing

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The purpose of this study was to translate, adapt and conduct initial psychometric validation of the French version of the Nurses' Attitudes and Perceptions of Pain Assessment in neonatal intensive care Questionnaire (NAPPAQ) developed by Polkki in 2010. Background: Assessing nurses' perceptions, attitudes and knowledge about pain management in preterm infants is important to improve neonatal practices. Methods: A sample of French-speaking nurses (n = 147) from Quebec and France working in neonatal intensive care was selected to validate the 46-item questionnaire. A French translation of the NAPPAQ, which includes Part I and II, was undertaken prior to its administration. The FIPM questionnaire was added as a Part III. Internal consistency and instrument structure were examined using Cronbach's alphas, inter-item and inter-scale correlations and exploratory factor analysis. Results: The NAPPAQ-FIPM is divided into three parts. Part I of the French version had a Cronbach's alpha of 0.64 and was composed of five factors. Part II had good total internal consistency (0.79) and adequate structure, established by inter-item correlations. Part III had good total internal consistency (0.76), and factor analysis findings suggested the presence of five factors. Conclusions: The NAPPAQ-FIPM can be used for research purposes. Parts II and III obtained adequate psychometrics results. However, further refinement of Part I could improve its content and internal structure.

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Systematic review and meta-analysis of olfactive stimulation interventions to manage procedural pain in preterm and full-term neonates

Cited by 15 publications

References 48 publications

Efficacy of Breast Milk Olfactory and Gustatory Interventions on Neonates’ Biobehavioral Responses to Pain during Heel Prick Procedures

Efficacy of Breast Milk Olfactory and Gustatory Interventions on Neonates’ Biobehavioral Responses to Pain during Heel Prick Procedures

Pain, Smell, and Taste in Adults: A Narrative Review of Multisensory Perception and Interaction

French Translation, Adaptation, and Initial Validation of the Nurses’ Attitudes and Perceptions of Pain Assessment in Neonatal Intensive Care Questionnaire (NAPPAQ)

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