Systematic review and meta‐analysis of the risk factors for sudden sensorineural hearing loss in adults

Lin, Rui; Krall, Randall; Westerberg, Brian D.; Chadha, Neil K.; Chau, Jason

doi:10.1002/lary.22480

Cited by 155 publications

(181 citation statements)

References 38 publications

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“…The presence of tinnitus was correlated with higher recovery rate, and the difference was close to statistical significance (p=0.071). Uri also reported better hearing outcome if tinnitus was present and worse outcome if vertigo was accompanied [13] . Although vertigo is considered a poor prognostic factor [1] , we did not notice any difference on hearing gain if vertigo was present.…”

Section: Discussionmentioning

confidence: 92%

“…In the vascular hypothesis, the blood supply of the cochlea seems to be compromised [5,13] . The cochlea receives blood from the labyrinthine artery, which is a small terminal artery and lacks collateral blood supply.…”

Section: Introductionmentioning

confidence: 99%

“…The cochlea receives blood from the labyrinthine artery, which is a small terminal artery and lacks collateral blood supply. Any ischemic effects (like vascular occlusion by emboli, vasospasm, acute vascular hemorrhage, or change in blood viscosity) can cause damage to the cochlea and thus hearing impairment [5,13] .…”

Section: Introductionmentioning

confidence: 99%

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A Comparison of Two Vasoactive/Vasodilative Agents in Combination with Corticosteroid for Treatment of Sudden Sensorineural Hearing Loss

Kordiš¹,

Žargi²,

Battelino³

2015

Int Adv Otol

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OBJECTIVE:Idiopathic sudden sensorineural hearing loss (ISSNHL) or sudden deafness is considered an otologic emergency. In spite of numerous investigations, its cause and treatment remain uncertain. Vascular hypothesis is one of the accepted etiologic theories, and vasodilator agents have been used to treat this medical condition. MATERIALS and METHODS:We conducted a retrospective study in which we have compared the efficiency of two vasoactive/vasodilative agents-pentoxifylline and betahistine-separately and together for treatment of sudden deafness in 59 patients. Methylprednisolone was used in all three groups. Hearing threshold (HT) was measured, and pure tone average (PTA) was calculated on admission, after 1 week, and after 3 months. RESULTS:Hearing improvement was noticed in 33 out of 59 patients (56%) at the second follow-up with a mean PTA improvement of 20 dB. The best recovery rate was seen in the pentoxifylline + steroid group (69%) versus the pentoxifylline + betahistine + steroid group (55%) and betahistine + steroid group (48%). There was no statistically significant difference in treatment outcome (p=0.433) between all three groups. Methylprednisolone dosage was 32, 48, or 64 mg/day. The amount of steroid given was not statistically significant for recovery of hearing loss (HL) (p=0.418). CONCLUSION:The pentoxifylline with methylprednisolone group achieved the best results. In that group, 67% of patients improved at the first follow-up versus 69% after 3 months. Statistically, there was no significant difference in treatment outcome between all three groups (p=0.433). Greater PTA improvement was seen at higher doses of steroid. The amount of steroid given was not found to have a statistically significant influence on hearing recovery (p=0.418).

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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A Comparison of Two Vasoactive/Vasodilative Agents in Combination with Corticosteroid for Treatment of Sudden Sensorineural Hearing Loss

Kordiš¹,

Žargi²,

Battelino³

2015

Int Adv Otol

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“…(17) yaptığı çalışmada ise, AİK olan hastalar hemostatik sorunlar açısından araştırıl-mış ve önemli bir bulguya rastlanmamıştır. AİK'lı hastalarda koenzim Q, folat, doymamış yağ asit dü-zeylerinde kontrol grubuna göre düşüklük saptanmış, ancak trigliserid seviyeleri ve AİK arasında anlamlı bir ilişkiye rastlanmamıştır (18) .…”

Section: Gereç Ve Yöntemunclassified

New Prognostic Parameters of Sudden Hearing Loss: Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio

Aydoğdu¹,

Yıldırım²,

Kumral³

et al. 2017

Okmeydani Medical Journal

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ÖZ Amaç: Ani işitme kaybı (AİK) en fazla üç gün içinde aniden Objective: Sudden hearing loss is a sensorineural hearing loss that develops within three days, leading to a minimum 30 dB hearing loss, involving at least three frequencies. This study aims to investigate the correlations between sudden sensorineural hearing loss with neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR).Material and Methods: 58 patients diagnosed with sudden sensorineural hearing loss were included in our study. Blood samples and the hearing assessments of the patients were carried out. Then, the patients were divided into 2 groups as "recovered" and "unrecovered" according

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“…2 Diabetes Mellitus is known to cause SNHL in adult population. Correlations between diabetes and decreased hearing acuity are present at high frequencies in diabetics more than in non-diabetics.…”

mentioning

confidence: 99%

Sensorineural Hearing Loss in Adults; (18-45 Years of Age)

Khan

Ashfaq

Ahmed³

et al. 2017

TPMJ

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ABSTRACT… Objectives:The objective of the study was to determine the etiology of SNHL in young adults between 18-45 years of age. Study design: Prospective study. Place and duration: The study was conducted at Benazir Bhutto Hospital, Rawalpindi from Jan 2012-13. Patients and methods: Patients presenting with hearing loss/ear blockage and additional symptoms were selected. Psychiatric problems were excluded from study. Patient's problem was analyzed through a protocol consisting of history, clinical examination, lab investigations, radiology and audiology. Results: The results of 25 patients were as follows: The age ranged from 18-45 years with marked preponderance of patients in 31-45 years age group amounting to 60% of the total cases.18-20 years groups were least affected. The incidence of SNHL gradually increased in older age groups. There were more female patients 56% of the total as compared to males, which were 44%. Bilateral SNHL was more 72% with compared to unilateral loss which was 28%. The mode of onset was insidious in 72% cases while sudden loss was 28%. The duration of symptoms ranged between 3 days to 15 years. While fluctuation of hearing loss was observed in one case (4%). The nature of problem ranged from mild to severe. Associated symptoms were present in different percentages. The hearing loss ranged from 10-80 decibel. Trauma was the major cause 28% followed by infections in 16% with various causes in various percentages. Conclusion: The trauma in the form of surgery, blast injury and occupational noise is the major cause of SNHL in adults ranging between 18-45 years of age. Males are more affected because of trauma than the females and younger groups more than older groups.

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Systematic review and meta‐analysis of the risk factors for sudden sensorineural hearing loss in adults

Abstract: Acquired and inherited cardiovascular risk factors appeared to be associated with an increased risk of developing SSNHL.

Cited by 155 publications

References 38 publications

A Comparison of Two Vasoactive/Vasodilative Agents in Combination with Corticosteroid for Treatment of Sudden Sensorineural Hearing Loss

A Comparison of Two Vasoactive/Vasodilative Agents in Combination with Corticosteroid for Treatment of Sudden Sensorineural Hearing Loss

New Prognostic Parameters of Sudden Hearing Loss: Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio

Sensorineural Hearing Loss in Adults; (18-45 Years of Age)

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