Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta2 agonists for the treatment of chronic asthma in children under the age of 12 years

Abstract

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Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta2 agonists for the treatment of chronic asthma in adults and children aged 12 years and over

“…Results pertaining to children, where reported separately, are presented in our accompanying assessment report for the efficacy and safety of ICS in children. 181 229 reported that mean FEV 1 increased from baseline values in both treatment groups. A comparison of the ratios of geometric means from a multiplicative model showed no significant between-group differences.…”

“…Consequently, a proportion of the 807 papers screened were included in that report. 181 Of these, 113 records describing 84 studies were included.…”

“…These included studies that were potentially relevant to the present assessment and also those relevant to the related technology assessment project on the clinical effectiveness and cost-effectiveness of ICS and LABAs for the treatment of chronic asthma in children under 12. 181 Of the titles and abstracts screened, 58 were ordered as full papers and assessed in detail.…”

The H Antigen at Epithelial Surfaces Is Associated with Susceptibility to Asthma Exacerbation

“…The rationale for this definition was that a lack of severe exacerbations since age 12 would definitively identify adults with exacerbationresistant asthma. The 12-year-old cut off has been used in other studies of asthma (11,12). Exclusion criteria included history of prednisone use for asthma after the age of 12 years but not within the past 2 years and history of current cigarette smoking.…”

Natural Surfactant Combined with Beclomethasone Decreases Lung Inflammation in the Preterm Lamb

“…To test this hypothesis, we evaluated cytokine changes in the bronchial aspirate fluid of preterm lambs that were randomized to receive natural surfactant plus beclomethasone or only a natural surfactant. We chose beclomethasone because it is cheap and its effectiveness is similar to that of other inhaled steroids [17]. Moreover, we decided to measure interleukin 6 (IL-6) and 8 (IL-8) and the macrophage migration inhibitory factor (MIF) because: (1) IL-6 is a proinflammatory cytokine which plays a relevant role in the pathogenesis of BPD in preterm infants [18]; (2) IL-8 is probably the most important chemotactic factor [18] in the human immune system; (3) MIF has recently been found to play a key role in pulmonary maturation and protection in newborn lung disease [19,20].…”