Systematic retinotopic reaching error vectors in unilateral optic ataxia

Blangero, Annabelle; Ota, Hisaaki; Rossetti, Yves; Fujii, Toshikatsu; Ohtake, Hiroto; Tabuchi, Mototsugu; Vighetto, Alain; Yamadori, Atsushi; Vindras, Philippe; Pisella, Laure

doi:10.1016/j.cortex.2009.02.015

Cited by 58 publications

(53 citation statements)

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“…More recent findings, however, have challenged this notion by providing evidence for a hand-target comparison in gaze-centered coordinates (Beurze et al 2006;Blangero et al 2007Blangero et al , 2010; Buneo et al 2002;Pisella et al 2009). …”

Section: Introductionmentioning

confidence: 93%

“…Buneo et al (2002) showed that position of the hand relative to gaze modulated the neuronal activity in area 5 of the posterior parietal cortex (PPC), whereas Pesaran et al (2006) discovered that reach-related activity in neurons in the dorsal premotor cortex depends on hand, eye, and target positions. Finally, unilateral and bilateral optic ataxia patients with damage in the PPC show reach deficits that reflect the use of gaze-centered coordinates (Blangero et al 2007(Blangero et al , 2009(Blangero et al , 2010Coslett 1997, 1998;Jackson et al 2009;Khan et al 2005a,b;Pisella et al 2009).…”

Section: Introductionmentioning

confidence: 99%

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Reference Frames for Reach Planning in Human Parietofrontal Cortex

Beurze

Toni

Pisella

et al. 2010

Journal of Neurophysiology

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To plan a reaching movement, the brain must integrate information about the spatial goal of the reach with positional information about the selected hand. Recent monkey neurophysiological evidence suggests that a mixture of reference frames is involved in this process. Here, using 3T functional magnetic resonance imaging (fMRI), we tested the role of gaze-centered and bodycentered reference frames in reach planning in the human brain. Fourteen human subjects planned and executed arm movements to memorized visual targets, while hand starting position and gaze direction were monitored and varied on a trial-by-trial basis. We further introduced a variable delay between target presentation and movement onset to dissociate cerebral preparatory activity from stimulusand movement-related responses. By varying the position of the target and hand relative to the gaze line, we distinguished cerebral responses that increased for those movements requiring the integration of peripheral target and hand positions in a gaze-centered frame. Posterior parietal and dorsal premotor areas showed such gaze-centered integration effects. In regions closer to the primary motor cortex, bodycentered hand position effects were found. These results suggest that, in humans, spatially contiguous neuronal populations operate in different frames of reference, supporting sensorimotor transformations according to gaze-centered or body-centered coordinates. The former appears suited for calculating a difference vector between target and hand location, whereas the latter may be related to the implementation of a joint-based motor command.

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Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Reference Frames for Reach Planning in Human Parietofrontal Cortex

Beurze

Toni

Pisella

et al. 2010

Journal of Neurophysiology

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“…At least post-acutely, patients reach accurately to fixated targets, but accuracy declines dramatically with eccentricity (Blangero, Ota et al, 2010;Perenin & Vighetto, 1988). It has been argued that this extrafoveal dependence is so fundamental that the definition of optic ataxia should exclude reaching errors in central vision (Jackson et al, 2009;Pisella et al, 2007Pisella et al, , 2008Pisella et al, , 2009.…”

Section: Introductionmentioning

confidence: 99%

Correlated deficits of perception and action in optic ataxia

et al. 2011

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a b s t r a c tOptic ataxia, following dorsal stream lesions, is characterised by impaired visuomotor guidance. Recent studies have found concurrent perceptual deficits, but it is unclear whether these are functionally related to the visuomotor symptoms. We studied the ability of a well-documented patient (IG) with bilateral optic ataxia to react to sudden target jumps by correcting ongoing reaches or by explicitly reporting the jump direction. IG showed deficient reach corrections, especially for target jumps to the visual periphery, and was similarly slow to discriminate the same jumps perceptually. Across six test conditions, in which the retinal locations of target jumps were varied, her perceptual slowing mirrored her reaching deficit precisely. These findings confirm perceptual impairments after dorsal stream lesions, and imply a shared functional basis with the classical visuomotor symptoms of optic ataxia. Additionally, we show that the online correction deficit is determined dually by the retinal location to which the reach must be diverted, and the location to which it is initially directed. We suggest that this deficit, and its perceptual counterpart, can be traced to a slowed contralesional orienting of attention in optic ataxia.

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“…In contrast, the functionally symmetrical dorsal network (including the superior parietal lobule (SPL) and the IPS) is involved in attentional shifts and visuo-motor transformations. Damage to this network potentially induces contralesional optic ataxia (OA) and contralesional visual extinction [31,32]. Corbetta et al [33] have provided evidence that a lesion restricted to the right TPJ causes clinical neglect because of (i) the direct damage to the ventral network and (ii) the resulting indirect imbalance of neuronal activity in the dorsal network, with increased activity in the left hemisphere resulting in lateralized bias of attention towards the right visual space.…”

Section: Introductionmentioning

confidence: 99%

Right-hemispheric dominance for visual remapping in humans

Pisella

Alahyane

Blangero

et al. 2011

Phil. Trans. R. Soc. B

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We review evidence showing a right-hemispheric dominance for visuo-spatial processing and representation in humans. Accordingly, visual disorganization symptoms (intuitively related to remapping impairments) are observed in both neglect and constructional apraxia. More specifically, we review findings from the intervening saccade paradigm in humans-and present additional original data-which suggest a specific role of the asymmetrical network at the temporo-parietal junction (TPJ) in the right hemisphere in visual remapping: following damage to the right dorsal posterior parietal cortex (PPC) as well as part of the corpus callosum connecting the PPC to the frontal lobes, patient OK in a double-step saccadic task exhibited an impairment when the second saccade had to be directed rightward. This singular and lateralized deficit cannot result solely from the patient's cortical lesion and, therefore, we propose that it is due to his callosal lesion that may specifically interrupt the interhemispheric transfer of information necessary to execute accurate rightward saccades towards a remapped target location. This suggests a specialized right-hemispheric network for visuo-spatial remapping that subsequently transfers target location information to downstream planning regions, which are symmetrically organized.

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Systematic retinotopic reaching error vectors in unilateral optic ataxia

Cited by 58 publications

References 50 publications

Reference Frames for Reach Planning in Human Parietofrontal Cortex

Reference Frames for Reach Planning in Human Parietofrontal Cortex

Correlated deficits of perception and action in optic ataxia

Right-hemispheric dominance for visual remapping in humans

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