Systematic quantification of nanoscopic dose enhancement of gold nanoparticles in ion beams

Fuß, Martina; Boscolo, Daria; Durante, Marco; Scifoni, E.; Krämer, M.

doi:10.1088/1361-6560/ab7504

Cited by 10 publications

(14 citation statements)

References 51 publications

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“…However, several experiments have shown significant sensitizations following proton irradiation, too (reviewed in [ 253 , 254 ]). Simulations for C-ions show large local dose enhancement in isolated nanoparticles, but do not identify any LET-dependence [ 255 , 256 ]. The additional problem in C-ion radiotherapy with nanoparticles is that the effect depends on the cross-section for the ion-nanoparticle interaction.…”

Section: Molecular Radiobiologymentioning

confidence: 99%

Carbon Ion Radiobiology

Tinganelli

Durante

2020

Cancers

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149

134

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Radiotherapy using accelerated charged particles is rapidly growing worldwide. About 85% of the cancer patients receiving particle therapy are irradiated with protons, which have physical advantages compared to X-rays but a similar biological response. In addition to the ballistic advantages, heavy ions present specific radiobiological features that can make them attractive for treating radioresistant, hypoxic tumors. An ideal heavy ion should have lower toxicity in the entrance channel (normal tissue) and be exquisitely effective in the target region (tumor). Carbon ions have been chosen because they represent the best combination in this direction. Normal tissue toxicities and second cancer risk are similar to those observed in conventional radiotherapy. In the target region, they have increased relative biological effectiveness and a reduced oxygen enhancement ratio compared to X-rays. Some radiobiological properties of densely ionizing carbon ions are so distinct from X-rays and protons that they can be considered as a different “drug” in oncology, and may elicit favorable responses such as an increased immune response and reduced angiogenesis and metastatic potential. The radiobiological properties of carbon ions should guide patient selection and treatment protocols to achieve optimal clinical results.

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Section: Molecular Radiobiologymentioning

confidence: 99%

Carbon Ion Radiobiology

Tinganelli

Durante

2020

Cancers

Self Cite

149

134

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“… 31 Fuss et al also excluded the importance of any indirect physical effects, that is, the dose enhancement only depends on the interaction between secondary electrons and AuNPs. 32 …”

Section: Discussionmentioning

confidence: 99%

“…31 Fuss et al also excluded the importance of any indirect physical effects, that is, the dose enhancement only depends on the interaction between secondary electrons and AuNPs. 32 Carbon ion irradiation led to the targeted necrosis and apoptosis of tumor tissue. The addition of mAuNPs could enhance the number of apoptotic cells in the tumor tissue.…”

Section: Radiosensitizing Mechanism Of Maunps Under Carbon Ion Irradiationmentioning

confidence: 99%

Therapeutic Efficacy of Carbon Ion Irradiation Enhanced by 11-MUA-Capped Gold Nanoparticles: An in vitro and in vivo Study

Zhang¹,

Yu²,

Jin³

et al. 2021

IJN

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Purpose: Gold nanoparticles (AuNPs) are widely studied as radiosensitizers, but their radiosensitization in carbon ion radiotherapy is unsatisfactory. There is a lack of in vivo data on the radiosensitization of AuNPs under carbon ion irradiation. This study focused on the radiosensitization effect of AuNPs in the mouse melanoma cell line B16-F10 in vitro and in vivo. Materials and Methods: 11-mercaptoundecanoic acid (11-MUA)-coated gold (Au) nanoparticles (mAuNPs) formulations were prepared and characterized. To verify the radiosensitization effect of mAuNPs, hydroxyl radicals were generated in aqueous solution, and the detection of intracellular reactive oxygen species (ROS) and clone survival were carried out in vitro. The tumor growth rate (TGR) and survival of mice were analyzed to verify the radiosensitization effect of mAuNPs in vivo. The apoptosis of tumor cells was detected, and the expression of key proteins in the apoptosis pathway was verified by immunohistochemistry. Results: The intracellular ROS level in B16-F10 cells was enhanced by mAuNPs under carbon ion irradiation. The sensitization rate of mAuNPs was 1.22 with a 10% cell survival rate. Compared with irradiation alone, the inhibitory effect of mAuNPs combined with carbon ion irradiation on tumor growth was 1.94-fold higher, the survival time of mice was prolonged by 1.75-fold, and the number of apoptotic cells was increased by 1.43-fold. The ratio of key proteins Bax and Bcl2 in the apoptosis pathway was up-regulated, and the expression of caspase-3, a key executor of the apoptosis pathway, was up-regulated. Conclusion:In in vivo and in vitro experiments, mAuNPs showed radiosensitivity to carbon ion irradiation. The sensitization effect of mAuNPs on mice tumor may be achieved by activating the mitochondrial apoptosis pathway and increasing tumor tissue apoptosis. To our best knowledge, the present study is the first in vivo evidence for radiosensitization of mAuNPs in tumor-bearing mice exposed to carbon ion irradiation.

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“…Another possibility is the enhancement of biologic effects by the collision of electrons (β-ray) with Mn elements. The collision of high energy charged particles with high-Z element enhances the biologic effects [45][46][47][48][49][50][51]. Therefore, the effects of electrons emitted from 56 Mn are also possibly enhanced with MnO 2 particles.…”

Section: Discussionmentioning

confidence: 99%

Impact of Local High Doses of Radiation by Neutron Activated Mn Dioxide Powder in Rat Lungs: Protracted Pathologic Damage Initiated by Internal Exposure

et al. 2020

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Internal radiation exposure from neutron-induced radioisotopes environmentally activated following atomic bombing or nuclear accidents should be considered for a complete picture of pathologic effects on survivors. Inhaled hot particles expose neighboring tissues to locally ultra-high doses of β-rays and can cause pathologic damage. 55MnO2 powder was activated by a nuclear reactor to make 56MnO2 which emits β-rays. Internal exposures were compared with external γ-rays. Male Wistar rats were administered activated powder by inhalation. Lung samples were observed by histological staining at six hours, three days, 14 days, two months, six months and eight months after the exposure. Synchrotron radiation—X-ray fluorescence—X-ray absorption near-edge structure (SR–XRF–XANES) was utilized for the chemical analysis of the activated 56Mn embedded in lung tissues. 56Mn beta energy spectrum around the particles was calculated to assess the local dose rate and accumulated dose. Hot particles located in the bronchiole and in damaged alveolar tissue were identified as accumulations of Mn and iron. Histological changes showed evidence of emphysema, hemorrhage and severe inflammation from six hours through eight months. Apoptosis was observed in the bronchiole epithelium. Our study shows early event damage from the locally ultra-high internal dose leads to pathogenesis. The trigger of emphysema and hemorrhage was likely early event damage to blood vessels integral to alveolar walls.

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Systematic quantification of nanoscopic dose enhancement of gold nanoparticles in ion beams

Cited by 10 publications

References 51 publications

Carbon Ion Radiobiology

Carbon Ion Radiobiology

Therapeutic Efficacy of Carbon Ion Irradiation Enhanced by 11-MUA-Capped Gold Nanoparticles: An in vitro and in vivo Study

Impact of Local High Doses of Radiation by Neutron Activated Mn Dioxide Powder in Rat Lungs: Protracted Pathologic Damage Initiated by Internal Exposure

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