Systematic Pharmacological Methodology to Explore the Pharmacological Mechanism of Siwu Decoction for Osteoporosis

Abstract

BackgroundOsteoporosis is an important health problem worldwide. Siwu decoction (SWD) and its modification have a good clinical effect on osteoporosis. However, the molecular mechanism of SWD on osteoporosis has not been thoroughly explained.Material/MethodsA systematic pharmacological methodology was utilized to predict the active compounds and potential targets of SWD, collect the genes of osteoporosis and the known targets of SWD, and analyze the osteoporosis and SWD’s network.ResultsFive networks were constructed and analyzed: (1) Osteoporosis genes’ protein–protein interaction (PPI) network; (2) Compound-compound target network of SWD; (3) SWD-osteoporosis PPI network; (4) Compound-known target network of SWD; and (5) SWD known target- osteoporosis PPI network. Several osteoporosis and treatment-related targets (eg.,. HSP90AB1, FGFR1, HRAS, GRB2, and PGF), clusters, biological processes, and signaling pathways (e.g., PI3K-Akt signaling pathway, insulin signaling pathway, MAPK signaling pathway and FoxO signaling pathway) were found.ConclusionsThe therapeutic effect of SWD on osteoporosis may be achieved by interfering with the biological processes and signaling pathways related to the development of osteoporosis.

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Integrating systematic biological and proteomics strategies to explore the pharmacological mechanism of danshen yin modified on atherosclerosis

“…48 The definition and the methodology of acquisition of clusters were described in our previous work. [19][20][21][22][23]…”

“…29 The compounds with OB ≥ 30%, Caco-2> −0.4 and DL ≥ 0.18 were considered to be orally absorbable and pharmacologically active (namely, potential compounds). [19][20][21][22][23][24][25][26][27]29 Due to the limitation of predicting potential components based on pharmacokinetic parameters only, 30 in order to avoid omission of components, we searched a large number of literatures to supplement orally absorbable compounds with bioactive. Finally, after searching, a total of 34 components were added from the reference.…”

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“…The network pharmacology strategy provides new opportunities for revealing complex traditional Chinese medicine prescriptions [ 20 – 24 ]. Traditional Chinese Medicine (TCM) treats diseases following a holistic view.…”

“…Network pharmacology is an important part of systematic biology. Its holistic, systemic, and drug-oriented interactions are in line with the basic characteristics of TCM, which is a new discipline that reveals the regulatory effects of compound drugs on the biological network of the body from a system level, and has established a bridge for studying the relationship between TCM and modern pharmacology [ 20 – 25 ]. Therefore, this study hopes to explore the molecular network of HDC intervention in DCM through a network pharmacology strategy.…”