Systematic Modification of the Glass Transition Temperature of Ion-Pair Comonomer Based Polyelectrolytes and Ionomers by Copolymerization with a Chemically Similar Cationic Monomer

Deng, Guodong; Schoch, Timothy D.; Cavicchi, Kevin A.

doi:10.3390/gels7020045

Cited by 6 publications

(3 citation statements)

References 46 publications

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“…For instance, in a polymer with multiple distinct monomeric units, it is possible for two monomeric components to segregate into the same phase, and interactions between repeat units may change chain mobility and hence the T g of a given phase. 50 It is also challenging to characterize the phase separation behavior of a copolymer when one of the T g s is unknown and above the degradation temperature, as is the case for SEMA. Nonetheless, thermal analysis can give insights into the self-assembly of these copolymers.…”

Section: Copolymer Characterizationmentioning

confidence: 99%

Amphiphilic Polyampholytes for Fouling-Resistant and Easily Tunable Membranes

Mazzaferro,

Lounder,

Asatekin

2023

ACS Appl. Mater. Interfaces

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The versatility of membranes is limited by the narrow range of material chemistries on the market, which cannot address many relevant separations. Expanding their use requires new membrane materials that can be tuned to address separations by providing the desired selectivity and robustness. Self-assembly is a versatile and scalable approach to create tunable membranes with a narrow pore size distribution. This study reports the first examples of a new class of membrane materials that derives stateof-the-art permeability, selectivity, and fouling resistance from the self-assembly of random polyampholyte amphiphilic copolymers. These membranes feature a network of ionic nanodomains that serve as nanochannels for water permeation, framed by hydrophobic nanodomains that preserve their structural integrity. This copolymer design approach enables precise selectivity control. For example, sodium sulfate rejections can be tuned from 5% to 93% with no significant change in the pore size or fouling resistance. Membranes developed here have potential applications in wastewater treatment and chemical separations.

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Section: Copolymer Characterizationmentioning

confidence: 99%

Amphiphilic Polyampholytes for Fouling-Resistant and Easily Tunable Membranes

Mazzaferro,

Lounder,

Asatekin

2023

ACS Appl. Mater. Interfaces

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“…Moreover, the agonism of β 3 -AR in brown adipose tissue increases glucose utilization in adipose tissue and promotes lipid metabolism for thermogenesis [40,41]. Long-term use of CL-316243 or BRL37344 (selective β 3 -AR agonists) increased glucose uptake in white and brown adipocytes without stimulating GLUT4 translocation [42]. Thus, the interaction of β 2 -ARs and β 3 -ARs accelerates glucose utilization and thermogenesis.…”

Section: Fzl Accelerated Liver Glycogenolysis Through Activation Of β...mentioning

confidence: 99%

Fuziline Ameliorates Glucose and Lipid Metabolism by Activating Beta Adrenergic Receptors to Stimulate Thermogenesis

Gao

Cheng

et al. 2023

IJMS

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Radix aconiti carmichaeli is a widely used traditional Chinese medicine that has been found to be effective in treating cardiovascular diseases and metabolic disorders. Patients with these diseases often experience a heat generation disorder, which is characterized by chilliness and can worsen the progression of the disease. This study established an in vitro screening model combining the examination of cellular mitochondrial membrane potential and mitochondrial temperature to screen drugs with thermogenic activity. After differentiation and determination of the content of characteristic metabolites of the drug-containing serum blood components, it was found that Fuziline (FZL) is the key thermogenic property in Radix aconiti carmichaeli, responsible for its thermogenic effects with a high relative importance of 33%. Experiments were conducted to evaluate the thermogenic activity of Radix aconiti carmichaeli and FZL in vivo by assessing temperature changes in various organs, including the rectum, liver, and brown adipose tissue. Moreover, the effects of intracellular β3-adrenergic receptor (β3-AR) agonistic effects were evaluated using transient β3-AR transfection and dual-luciferase assay systems. The molecular mechanism by which FZL promotes thermogenesis and improves mitochondrial function was investigated by verifying the β-adrenergic receptors (β-AR) downstream signaling pathway. The results suggest that FZL activates β-AR nonselectively, which in turn activates the downstream cAMP-PKA signaling pathway and leads to an increase in liver glycogenolysis and triglyceride hydrolysis, accompanied by enhancing mitochondrial energy metabolism. Consequently, the liver and brown adipose tissue receive energy to generate heat. In summary, these findings provide insight into the therapeutic application of Radix aconiti carmichaeli for metabolic disorders associated with heat generation disorders.

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“…Thus, the bridged ionomers have tunable mechanical properties since the strength of physical cross-linking can be controlled. In another research study, Deng et al 33 synthesized a copolymer of the bridged and pendant ionomers and were able to monotonically tune the T g by varying the fraction of bridged ion pairs. A molecular-level understanding of phase behavior and ionic dynamics and their dependence on different parameters, such as chain architecture, is required to design the ionomer for the desired application.…”

Section: Introductionmentioning

confidence: 99%

Microscopic Morphology and Dynamics of Polyampholyte and Cationic Ionomers

Sadeghi,

Kim,

Cavicchi

et al. 2024

Macromolecules

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Molecular dynamics (MD) simulations are performed using a coarse-grained model of polyampholyte ionomers in which both types of ions are incorporated in the polymer chain and, consequently, the ion-pairs form bridges across the chains (i.e., bridged ion-pair) and compared their dynamics and structures with the conventional cationic ionomers, where only cations are incorporated into the polymer chain (e.g., pendant ion-pair). While the glass transition temperatures of both structures are comparable, mesoscale ordering within large, string-like aggregates is observed in the polyampholyte (bridged) ionomer instead of square-like aggregates in the cationic (pendant) ionomer. Both systems show dynamical heterogeneities at temperatures above T g , which persist at higher temperatures for the bridged ionomers. A linear correlation between the lifetime of the ionic bonds and the dynamic relaxation time over a wide temperature range is observed. A comparison of these time scales showed that ions have collective dynamics in the bridged ionomers. Furthermore, the intermediate scattering function data obtained at different temperatures can collapse onto master curves, which confirms the applicability of the time−temperature superposition principle in these structures. Overall, this study shows that modifying the chain connectivity of the ion-pairs provides an alternative route to control the morphology and dynamics of ionomers.

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Systematic Modification of the Glass Transition Temperature of Ion-Pair Comonomer Based Polyelectrolytes and Ionomers by Copolymerization with a Chemically Similar Cationic Monomer

Cited by 6 publications

References 46 publications

Amphiphilic Polyampholytes for Fouling-Resistant and Easily Tunable Membranes

Amphiphilic Polyampholytes for Fouling-Resistant and Easily Tunable Membranes

Fuziline Ameliorates Glucose and Lipid Metabolism by Activating Beta Adrenergic Receptors to Stimulate Thermogenesis

Microscopic Morphology and Dynamics of Polyampholyte and Cationic Ionomers

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