Systematic meta-analyses and field synopsis of genetic association studies of violence and aggression

Vassos, Evangelos; Collier, David A.; Fazel, Seena

doi:10.1038/mp.2013.31

Cited by 216 publications

(103 citation statements)

References 60 publications

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“…Aggression also constitutes the sixth highest cause of disability in young people worldwide and contributes to approximately 5% of all disability [Vassos et al, 2014]. A study of the burden of crime on USA services found that $3% of expenses were secondary to violent crime driven by aggression.…”

Section: Introductionmentioning

confidence: 99%

Comparative mRNA analysis of behavioral and genetic mouse models of aggression

Malki

Tosto

Pain

et al. 2016

American J of Med Genetics Pt B

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Mouse models of aggression have traditionally compared strains, most notably BALB/cJ and C57BL/6. However, these strains were not designed to study aggression despite differences in aggression-related traits and distinct reactivity to stress. This study evaluated expression of genes differentially regulated in a stress (behavioral) mouse model of aggression with those from a recent genetic mouse model aggression. The study used a discovery-replication design using two independent mRNA studies from mouse brain tissue. The discovery study identified strain (BALB/cJ and C57BL/6J) × stress (chronic mild stress or control) interactions. Probe sets differentially regulated in the discovery set were intersected with those uncovered in the replication study, which evaluated differences between high and low aggressive animals from three strains specifically bred to study aggression. Network analysis was conducted on overlapping genes uncovered across both studies. A significant overlap was found with the genetic mouse study sharing 1,916 probe sets with the stress model. Fifty-one probe sets were found to be strongly dysregulated across both studies mapping to 50 known genes. Network analysis revealed two plausible pathways including one centered on the UBC gene hub which encodes ubiquitin, a protein well-known for protein degradation, and another on P38 MAPK. Findings from this study support the stress model of aggression, which showed remarkable molecular overlap with a genetic model. The study uncovered a set of candidate genes including the Erg2 gene, which has previously been implicated in different psychopathologies. The gene networks uncovered points at a Redox pathway as potentially being implicated in aggressive related behaviors.

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Section: Introductionmentioning

confidence: 99%

Comparative mRNA analysis of behavioral and genetic mouse models of aggression

Malki

Tosto

Pain

et al. 2016

American J of Med Genetics Pt B

View full text Add to dashboard Cite

show abstract

“…Several genetic variants have been identified that incrementally increase the risk for antisocial behavior [4][5][6][7] . Although approximately half of 185 studies have reported effects, a meta-analysis revealed that no variant was associated with aggression at the 5% level of significance 8 . This finding underscores the idea that, as with other complex behaviors, the contribution of any single gene is likely to be quite small.…”

Section: Geneticsmentioning

confidence: 99%

Neurocriminology: implications for the punishment, prediction and prevention of criminal behaviour

2013

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Criminal behaviour and violence are increasingly viewed as worldwide public health problems. A growing body of knowledge shows that criminal behaviour has a neurobiological basis, and this has intensified judicial interest in the potential application of neuroscience to criminal law. It also gives rise to important questions. What are the implications of such application for predicting future criminal behaviour and protecting society? Can it be used to prevent violence? And what are the implications for the way offenders are punished?

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“…Violent conduct may reflect a dysfunction of the neural mechanisms involved in the control of this response (Anderson & Bushman, 2002). In any event, and following Vassos, Collier, and Fazel (2104), aggression and violence would form part of the same behavioural continuum.…”

Section: Introductionmentioning

confidence: 99%

Socio-cognitive and personal characteristics of young offenders: a field study

Borrás¹,

Pol²,

Hernández

et al. 2017

Int. j. psychol. res.

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Adolescence is characterised by a higher prevalence of risk-taking and the challenging of social norms, which appears to bear a relationship to personal abilities and social-cognitive deficits. With the aim of understanding this relationship, a comparative study was undertaken with two groups of adolescents, one belonging to the standard population and one comprising young people who have been subject to correctional measures. In order to evaluate the variables involved, use was made of the Questionnaire for the Assessment of Psychopathology in Adolescence (Q-PAD). The results obtained show that both groups display significant differences in all the variables considered in the Questionnaire, with the exception of those relating to body dissatisfaction and family conflicts. Succinctly, it emerged that the juvenile offenders had emotional and interpersonal problems and were at risk of psychological disturbance. They demonstrated uncertainty about the future, liability to substance abuse, and issues of self-esteem. These results suggest the need for prevention and intervention programmes which specifically take into account these variables. ResumenLa adolescencia constituye una etapa caracterizada por una mayor prevalencia de conductas de riesgo y antinormativas que se relacionan con competencias personales y sociocognitivas deficitarias. Al objeto de conocer dicha relación, se llevó a cabo un estudio comparativo con dos grupos de adolescentes -uno perteneciente a la población normal (n = 35) y el otro compuesto por jóvenes sujetos a medidas de reforma (n = 44) -. Para la evaluación de las variables objeto de estudio se utilizó el Cuestionario para la Evaluación de Problemas en Adolescentes (Q-PAD). Los resultados obtenidos ponen de manifiesto que ambos grupos presentan diferencias significativas en todas las variables contempladas en el instrumento a excepción de las relativas a la insatisfacción corporal y a los conflictos familiares. Sucintamente, se encontró que los menores infractores presentan problemas emocionales, interpersonales, de riesgo psicosocial, incertidumbre sobre el futuro, abuso de sustancias y de autoestima. Los resultados sugieren la necesidad de programas de prevención e intervención que contemplen dichas variables de forma específica.

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Systematic meta-analyses and field synopsis of genetic association studies of violence and aggression

Cited by 216 publications

References 60 publications

Comparative mRNA analysis of behavioral and genetic mouse models of aggression

Comparative mRNA analysis of behavioral and genetic mouse models of aggression

Neurocriminology: implications for the punishment, prediction and prevention of criminal behaviour

Socio-cognitive and personal characteristics of young offenders: a field study

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