Abstract:Background
COVID-19 could develop severe respiratory symptoms in certain infected patients, especially in the patients with immune disorders. Gut microbiome and plasma metabolome act important immunological modulators in the human body and could contribute to the immune responses impacting the progression of COVID-19.
Methods
Based on two-sample Mendelian randomization framework, the causal effects of 131 microbiota in genus or species level and 452 plasma metabolites on severe COVID-19 are estimated. Single… Show more
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