Systematic mediastinal lymphadenectomy does not increase postoperative immune response after major lung resections☆

Abstract

Systematic lymphadenectomy added to major lung resection does not increase postoperative humoral immune response in uncomplicated cases, as measured by levels of IL-6 and IL-1 ra in serum, pleural fluid, and sputum.

Comparison of lobe-specific mediastinal lymphadenectomy versus systematic mediastinal lymphadenectomy for clinical stage T 1a N 0 M 0 non-small cell lung cancer

“…In addition, lymph nodes have an important defensive function and SL can cause reduction of local immune function so that local recurrence or distant metastasis of the tumor may occur. [10] Therefore, SL cannot more benefit than LL. Our study found that LL group has a significant advantage in shortening the time of operation, decreasing blood loss and reducing the incidence of post-operative complications compared with SL group.…”

Comparison of Systematic Mediastinal Lymph Node Dissection Versus Systematic Sampling for Lung Cancer Staging and Completeness of Surgery

“…In a non-randomized control trial, Keller et al implied that SS is as efficacious as SMLD at staging [9]. However, debate still exists on the best procedure for lymph node management on different sides [19]. For the left, some surgeons perform less S (-) D (-) ¼ negative node in SS, additional negative node in SMLD; S (-) D (þ) ¼ negative node in SS, additional positive node in SMLD; S (þ) D (þ) ¼ positive node in SS; NPV ¼ negative predictive value; SMLD ¼ systematic lymph node dissection; SS ¼ systematic sampling.…”

Video-Assisted Thoracic Surgery (VATS) Systematic Mediastinal Nodal Dissection

“…It was reported that Systematic lymphadenectomy added to major lung resection performed by open thoracotomy does not increase postoperative humoral immune response in uncomplicated cases [35]. However; there are no studies in the literature that looked into the VMPR-SND and the role of SND in postoperative inflammatory response.…”