Systematic Long-term Follow Up After Endovascular Abdominal Aortic Aneurysm Repair With the Zenith Stent Graft

Abstract

This paper reports the 16 year outcomes of elective endovascular aneurysm repair (EVAR) with the Zenith stent graft. The results indicate that graft related complications keep appearing years after the primary procedure, suggesting mandatory lifelong surveillance. Abdominal aortic aneurysm rupture is rare after EVAR, with a mean annual risk of 0.5%, and is not prevented by regular follow up.Objective/Background: Although endovascular aneurysm repair (EVAR) has been widely adopted, long-term data remain limited. This study analyses the long-term outcome (16 years) after EVAR with the Zenith stent graft in a single academic centre. Methods: From 2000 to 2010, 282 patients with an abdominal aortic aneurysm (AAA) were treated electively and monitored annually. Primary outcomes were overall and AAA rupture free survival; the secondary outcomes were complication and re-intervention free survival. KaplaneMeier analysis was used to examine survival. Results: The median patient age was 76 years (range 49e92 years) and mean aneurysm diameter 61 mm (range 40e110 mm). Patients were followed for a median of 76 months (range 0e201 months). Overall survival was 93% (SE 0.02), 61% (SE 0.08), 25% (SE 0.16), and 9% (0.19) at 1, 2, 5, 10, and 16 years, respectively. Ten (3.5%) AAA ruptures occurred, and the cumulative AAA rupture free survival was 100%, 98% (SE 0.01), 96% (SE0.02), and 79% (SE 0.12) at 1, 5, 10, and 16 years, respectively. The mean annual AAA rupture rate was 0.5%. Freedom from any stent graft related complications was 68% (SE 0.03), 58% (SE 0.09), 54% (SE 0.17), and 52% (SE 0.21), respectively; freedom from graft related re-interventions was 95% (SE 0.01), 80% (SE 0.08), 73% (SE 0.11), 70% (SE 0.16), at 1, 5, 10, and 16 years, respectively. Five (1.8%) late conversions were required during follow up. The variables that significantly and independently correlated with ruptured AAA were pre-operative aneurysm size and primary type II endoleak. The latter was the only independent significant factor to increase the risk of re-intervention. Conclusion:The number of graft related complications is high after EVAR, and new complications keep appearing years after the initial procedure. Even though fatal AAA rupture after EVAR is rare, it cannot be totally avoided despite systematic follow up.

Outcomes of Endovascular Aneurysm Repair Using the Anaconda Stent-Graft

“…The low 1.4% rate of aneurysm-related mortality would be expected in patients who fulfill the anatomical criteria for EVAR and are relatively free from aneurysm-related complications and secondary interventions. Vaaramaki et al 27 recently reported long-term follow-up of patients treated with the Zenith stent-graft. Ten patients (3.5%) experienced rupture after EVAR, 7 of them due to type I endoleak during a mean follow-up of 76 months.…”

Analysis of Outcomes After Endovascular Abdominal Aortic Aneurysm Repair in Patients With Abnormal Findings on the First Postoperative Computed Tomography Angiography

“…After this period the need for secondary interventions continues to remain stable over time similar to other long-term studies. 24,25 The majority of patients with an abnormal CTA that underwent a secondary intervention were asymptomatic and underwent their first intervention due to surveillance imaging after EVAR. A smaller proportion presented with symptoms, all of whom needed secondary intervention.…”

One Year on: Test Your Knowledge From August 2019

“…2 days C. 3 days D. 5 days E. 7 days 2. The re-intervention rate at ten years after endovascular aneurysm repair (EVAR) with the Zenith stent graft is 2 A. 7% B.…”