Systematic Literature Review on the Incidence and Prevalence of Heart Failure in Children and Adolescents

Shaddy, Robert E.; George, Aneesh Thomas; Jaecklin, Thomas; Lochlainn, Eimear Nic; Thakur, Lalit; Agrawal, R.; Solar-Yohay, Susan; Chen, Fabian; Rossano, Joseph W.; Severin, Thomas; Burch, Michael

doi:10.1007/s00246-017-1787-2

Cited by 58 publications

(47 citation statements)

References 79 publications

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“…Symptomatic atrial septal defects or clinically manifested heart failure has been reported to be present in 11.6-20% of children with atrial septal defect and even more common in children with large atrial septal defects. 33,34 This is in line with our study, as 48 (12%) of the children had symptomatic atrial septal defects. This rules out the risk of selection bias due to overtreatment in our study.…”

Section: Discussionsupporting

confidence: 90%

Risk factors for adverse events within one year after atrial septal closure in children: a retrospective follow-up study

et al. 2019

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Introduction:Secundum atrial septal defect is one of the most common congenital heart defects. Previous paediatric studies have mainly addressed echocardiographic and few clinical factors among children associated with adverse events. The aim of this study was to identify neonatal and other clinical risk factors associated with adverse events up to one year after closure of atrial septal defect.Methods:This retrospective case–control study includes children born in Sweden between 2000 and 2014 that were treated surgically or percutaneously for an atrial septal defect. Conditional logistic regression was used to evaluate the association between major and minor adverse events and potential risk factors, adjusting for confounding factors including prematurity, neonatal sepsis, neonatal general ventilatory support, symptomatic atrial septal defects, and pulmonary hypertension.Results:Overall, 396 children with 400 atrial septal defect closures were included. The median body weight at closure was 14.5 (3.5–110) kg, and the median age was 3.0 (0.1–17.8) years. Overall, 110 minor adverse events and 68 major events were recorded in 87 and 49 children, respectively. Only symptomatic atrial septal defects were associated with both minor (odds ratio (OR) = 2.18, confidence interval (CI) 95% 1.05–8.06) and major (OR = 2.80 CI 95% 1.23–6.37) adverse events.Conclusion:There was no association between the investigated neonatal comorbidities and major or minor events after atrial septal defect closure. Patients with symptomatic atrial septal defects had a two to four times increased risk of having a major event, suggesting careful management and follow-up of these children prior to and after closure.

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Section: Discussionsupporting

confidence: 90%

Risk factors for adverse events within one year after atrial septal closure in children: a retrospective follow-up study

et al. 2019

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“…The other main cause of pediatric HF is cardiomyopathy (predominantly dilated cardiomyopathy), with an estimated annual incidence of 1 per 100,000 children in the US, Australia, United Kingdom (UK), and Ireland [ 11 , 12 , 13 ]. Recently, Shaddy et al have described the incidence of HF ranging from 0.87/100,000 (UK and Ireland), 7.4/100,000 (Taiwan), and 83.3/100,000 (Spain) [ 14 ]. Key findings of their study included a prevalence of HF associated with cardiomyopathies ranging from 36.1% (Japan) to 79% (US); associated with CHD from 8% (Norway) to 82.2% (Nigeria); associated with rheumatic heart diseases from 1.5% (Turkey) to 74% (Zimbabwe); associated with renal disorders from 3.8% (India) to 24.1% (Nigeria); and associated with HIV from 1% (US) to 29.3% (Brazil).…”

Section: Incidence and Prevalencementioning

confidence: 99%

Current State of Pediatric Heart Failure

Das

2018

Children

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Pediatric heart failure (HF) represents an important cause of morbidity and mortality in childhood. There is an overlapping relationship of HF, congenital heart disease, and cardiomyopathy. The goal of treatment of HF in children is to maintain stability, prevent progression, and provide a reasonable milieu to allow somatic growth and optimal development. Current management and therapy for HF in children are extrapolated from treatment approaches in adults. There are significant barriers in applying adult data to children because of developmental factors, age variation from birth to adolescence, and differences in the genetic expression profile and β-adrenergic signaling. At the same time, there are significant challenges in performing well-designed drug trials in children with HF because of heterogeneity of diagnoses identifying a clinically relevant outcome with a high event rate, and a difficulty in achieving sufficient enrollment. A judicious balance between extrapolation from adult HF guidelines and the development of child-specific data on treatment represent a wise approach to optimize pediatric HF management. This approach is helpful as reflected by the increasing role of ventricular assist devices in the management of advanced HF in children. This review discusses the causes, epidemiology, pathophysiology, clinical manifestations, conventional medical treatment, clinical trials, and the role of device therapy in pediatric HF.

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“…Levosimendan povisuje unutarstaničnu koncentraciju kalcija i time ima pozitivno inotropno djelovanje, ali bez aritmogenog učinka. [78][79][80][81][82] Sve se češće indicira njegova primjena u jedinicama intenzivnog liječenja novorođenčadi. U našoj zemlji već se niz godina u nekoliko centara izvodi ehokardiografski probir na prirođene srčane greške.…”

Section: Srčane Greške Ovisne O Arterijskom (Botallovu) Duktusuunclassified

Clinical Manifestation of Late Neonatal Sepsis – Continu-Ous Differential Diagnostic Dilemma

Katavić

Buljević

2018

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Neonatal sepsis as a clinical syndrome is one of the most common challenges in neonatal medicine with a relatively high mortality rate. At the time of clinical manifestation it can be distinguished into early onset and late onset sepsis, highly depending on sources and medical experts opinions.Its multiorgan affection can be associated with major complications and high late morbidity and mortality. The period of the second week of life is the primary interest of this paper, because children who were thought to be healthy are discharged home from the maternity ward, more or less successfully adapted to extrauterine life with the possibility of developing serial noninfectious conditions and diseases that clinically impress as sepsis. Such state can make serious differental diagnostic difficulty and requires quick reaction with timely and appropriate therapy that could be crucial in the management of these patients. Definitive care should be continued in an adequate institution, depending on diagnosis. The aim of this review is pointing out the wide range of noninfectious conditions that can present as late onset neonatal sepsis.

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Systematic Literature Review on the Incidence and Prevalence of Heart Failure in Children and Adolescents

Cited by 58 publications

References 79 publications

Risk factors for adverse events within one year after atrial septal closure in children: a retrospective follow-up study

Risk factors for adverse events within one year after atrial septal closure in children: a retrospective follow-up study

Current State of Pediatric Heart Failure

Clinical Manifestation of Late Neonatal Sepsis – Continu-Ous Differential Diagnostic Dilemma

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