Abstract:Controlling the expression levels of multiple recombinant proteins for optimal performance is crucial for synthetic biosystems but remains difficult given the large number of DNA-encoded factors that influence the process of gene expression from transcription to translation. In bacterial hosts, biosystems can be economically encoded as operons, but the sequence requirements for exact tuning of expression levels in an operon remain unclear. Here, we demonstrate the extent and predictability of protein-level var… Show more
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