Systematic investigation of functional core variation within hyperbranched polyglycerols

Abstract

A novel series of hyperbranched polyether polyols with various n‐alkyl amine cores (mono‐ and bifunctional) and photoactive cores (benzylamine and 1‐naphthylmethylamine) have been prepared. Polymerization of glycidol was carried out in two ways, starting directly from primary amine initiators and from bisglycidolized amine initiators. NMR spectroscopy and size exclusion chromatography (SEC) showed good control over the molecular weights only, when bisglycidolized amines were used. Molecular weights and polydispersity of the hyperbranched polyglycerols prepared with these initiator‐cores were in the range of 1600 to 8400 g/mol and of 1.5 to 2.5, respectively. MALDI‐ToF mass spectrometry confirmed covalent attachment of the functional cores to the hyperbranched polymers. When using the bis‐glycidolized amine‐initiators, only functionally initiated polymers could be observed. In contrast, the direct amine‐initiated polymers always showed the presence of nonfunctionalized PG homopolymer. Steady‐state and time‐resolved fluorescence measurements further support covalent attachment and site isolation of the functional initiators within the hyperbranched structure. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 2049–2061, 2008

Dendritic Polyglycerols for Biomedical Applications

“…[120] A systematic investigation of utilizing different functional cores within hyperbranched PGs has also been carried out by Frey and coworkers. [121] They reported the preparation of a novel series of hyperbranched polyether polyols with various n-alkyl amine cores (mono-and bifunctional) and photoactive cores (benzylamine and 1-naphthylmethylamine). Polymerization of glycidol was carried out either directly from the primary amine initiators or from bisglycidolized amine initators.…”

Stimulus responsive fluorescent hyperbranched polymers and their applications

“…Meanwhile, they reported another FHBP named hyperbranched polyglycerol with naphthalene as the core [80]. As the amino-group is proximate to the core, the PL intensity of the polymer is pH-dependent.…”

Branched aliphatic polyesters by ring-opening (co)polymerization

“…The method of synthesis of hyperbranched polymers by the ROMBR (ring-opening multibranching polymerization) of "latent" AB 2 cyclic monomers is predominantly exploited A c c e p t e d M a n u s c r i p t 11 for hydroxyl-substituted cyclic ethers like 3-membered hydroxymethyloxiranes [24,[55][56][57][58][59][60][61][62][63] or 4-membered hydroxymethyloxetanes [64][65][66][67][68][69][70][71][72][73].…”