Systematic in vitro and in vivo study on porous silicon to improve the oral bioavailability of celecoxib

Tailoring Porous Silicon for Biomedical Applications: From Drug Delivery to Cancer Immunotherapy

“…The pore size and porosity/pore volume of PSi can be precisely controlled by manipulating the fabrication parameters, and its biodegradability can be adjusted by porosity and pore size . Importantly, PSi possesses several particularly appealing tunable properties for designing drug delivery systems: (1) high porosity/large pore volume (≈50–80%/≈0.5–2.0 cm 3 g −1 ) for achieving high loading degree of payloads; (2) tunable pore size (≈5–150 nm) for loading a broad range of small molecules, macromolecules, and nanoparticles; (3) versatile surface chemistry and high specific surface area (up to 580 m 2 g −1 ) that can be surface functionalized for controlled drug release and (multiple) biological functions; (4) excellent biocompatibility and the ability to completely degrade into nontoxic orthosilicic acid [Si(OH) 4 ], which is naturally present in the human body . The PSi for constructing drug delivery systems are mostly (quasi) spherical shaped micro‐ and nanoparticles due to their wide applicability and easiness of fabrication.…”

From The Mine to Cancer Therapy: Natural and Biodegradable Theranostic Silicon Nanocarriers from Diatoms for Sustained Delivery of Chemotherapeutics

“…Considering different materials, micro and nanocarriers based on silicon materials have been recognized as promising alternatives to polymer materials for drug delivery applications because of their unique physical, chemical and optical properties . In particular, porous silicon nanoparticles (SiNPs) obtained by electrochemical etching of silicon wafers have been recognized as promising candidate as chemotherapeutic carrier for cancer treatment having some desirable properties to overcame biological barriers such as high surface area, high drug loading capacity, tunable pore morphology and surface chemistry, chemical inertness, excellent biocompatibility, and biodegradability . In addition, silicon is biodegradable and can be readily excreted by kidneys, as demonstrated in animal models .…”

“…In addition, silicon is biodegradable and can be readily excreted by kidneys, as demonstrated in animal models . Porous SiNPs can be produced with engineered chemical and physical properties (e.g., large surface area, significantly high pore volumes, high drug loading capacity together with the ability to stabilize loaded drugs within its pores and possibility of surface modification for sustained and triggered release) . Another important feature of porous SiNPs is that they can be precisely engineered as photonic crystals with photoluminescent properties and provide theranostic functions such as in‐vivo imaging and self‐reporting, drug‐release and degradation .…”

Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles, and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics

“…XMU‐MP‐1 is a highly insoluble drug in different solvents and it is very difficult to be administered (Table S1, Supporting Information). PSi has been showed to have the ability to improve the in vivo drug bioavailability, especially for hydrophobic drug . Without the application of DPSi, by using the same drug encapsulation procedure, the drug loading degree within the AcDEX matrix is as low as 0.04%.…”