Systematic Immune-Inflammation Index Predicts Embolic Events in Infective Endocarditis

Abstract

Infective endocarditis (IE) is a life-threatening disease with embolisms occurring in 20%-50% of cases. We aimed to evaluate the value of the systemic immune-inflammation index (SII) in predicting embolic events (EEs) in patients with infective endocarditis.A total of 186 patients diagnosed with definite IE, who admitted to the Union Hospital affiliated to Tongji Medical College, Huazhong University of Science and Technology, were retrospectively identified from November 2011 to March 2019.The median (interquartile) age of the patients was 46 (32-57) years. Viridans group streptococci were the most common microorganism identified from blood culture (24.7%). The most frequent complication was heart failure (64.2%), followed by EEs (30.2%). Patients complicated with EEs presented a significantly higher SII than those without EEs (1605.38 versus 1039.61, P = 0.001). SII had an area under the curve (AUC) value for EEs of 0.661 (95% CI: 0.575-0.747, P = 0.001), which predicted the presence of EEs with a sensitivity of 42.6% and specificity of 86.3%. Multivariate logistic regression analysis revealed that SII (OR = 6.925; 95% CI: 1.035-46.318, P = 0.046) was an independent predictor of EEs in IE patients.We demonstrated that a high level of SII is associated with a higher likelihood of EEs. The SII may be a promising predictor for EEs in patients with IE.

The Systemic Immune-Inflammation Index and Predicting Cardiac Implantable Electronic Device Infections

“…24 Having higher SII was associated with embolic events in these patients. 31 In the present study, patients with CIED infection had higher SII values before the procedure compared with those without CIED infection. Higher SII before the procedure may be a sign of infection or inflammation, especially in cases having early infection risk.…”

Comparison of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) as marker of adverse prognosis in patients with infective endocarditis

“… 5 Recently two studies have found that high SII levels are independently associated with mortality and embolic events in IE. 6 , 7 NLR has been shown to have a high predictive value for many cardiovascular diseases. However, data are scarce on its predictive value in IE patients.…”