Abstract:Expansion of short tandem repeats (STRs) in the human genome underlies over fifty genetic disorders. A common pathological feature of repeat RNAs is their propensity to aggregate in cells. While these RNA aggregates have been shown to cause toxicity by sequestering RNA-binding proteins, the molecular mechanism of repeat RNA aggregation remains unclear. Here we devised a generalizable method to efficiently generate long tandem repeat DNAs de novo and applied it to systematically determine the sequence features … Show more
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