Systematic evaluation of MRI findings in different stages of treatment of cervical cancer: Potential of MRI on delineation of target, pathoanatomic structures, and organs at risk

Dimopoulos, Johannes; Schard, Gerdi; Berger, Daniel; Lang, Stefan; Goldner, Gregor; Helbich, T; Pötter, Richard

doi:10.1016/j.ijrobp.2005.10.017

Cited by 115 publications

(62 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The value of MRI for the delineation procedure in IGBT has already been validated by us [9]. The gross tumor volume at diagnosis (GTV D ) and at brachytherapy (GTV BT ), the high-risk clinical target volume (HR-CTV), the anatomic structures of interest (bladder, rectum, sigmoid, parametria), and the applicator can all be accurately imaged [9].…”

Section: Introductionmentioning

confidence: 99%

MRI Assessment of Cervical Cancer for Adaptive Radiotherapy

et al. 2009

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

MRI Assessment of Cervical Cancer for Adaptive Radiotherapy

et al. 2009

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the late 1990s, MRI-guided adaptive brachytherapy was first introduced into treatment planning for brachytherapy. MRI allows tailoring of dose distribution according to the tumour topography while sparing critical adjacent organs [5][6][7][8][9][10]. Target volume definitions for MRI and recommendations for concepts in treatment planning have been published by the Gynaecological GEC-ESTRO Working Group [11][12][13][14].…”

mentioning

confidence: 99%

MRI-based pre-planning in patients with cervical cancer treated with three-dimensional brachytherapy

Doležel¹,

Odrážka²,

Vaňásek³

et al. 2011

BJR

View full text Add to dashboard Cite

Objective: The aim of this study was to analyse the feasibility and determine the benefits of MRI-based pre-planning with CT/MRI data fusion in patients with cervical cancer treated with radical radiotherapy. Methods: Patients underwent MRI examination prior to external beam radiotherapy and prior to the first and fourth fraction of brachytherapy with applicators in place. Insertion of applicators at the radiology department was performed under paracervical anaesthesia. The benefit of MRI pre-planning was determined by comparing conventional treatment planning with dose specification to \point A" and dose specification to 90% of the high-risk clinical target volume (HR-CTV D90). Tolerance of MRI evaluation with applicators, coverage of HR-CTV and dose-volume parameters for organs at risk (OAR) has been assessed in 42 brachytherapy procedures. Results: Insertion of applicators at the radiology department was successful in all patients and there were no complications. The target dose was higher for MRI planning than for conventional planning (5.3 Gy vs 4.5 Gy). Maximum doses in the bladder and rectum were significantly lower (p,0.05) for MRI planning than for the conventional approach (6.49 Gy vs 7.45 Gy for bladder; 4.57 Gy vs 5.06 Gy for rectum). We found no correlation between the International Commission on Radiation Units (ICRU) point dose for OAR and the maximum dose in OAR. Nevertheless, a strong correlation between the maximum dose in OAR and the minimal dose in a volume of 2 cm 3 has been observed. Conclusion: MRI-based pre-planning with consecutive CT/MRI data fusion is feasible and safe, with the advantage of increasing the dose to the tumour and decreasing the dose to the organs at risk.

show abstract

“…The urine was then allowed to drain with gravity to attain a constant bladder filling. MRI imaging was done in accordance with the protocol described by Dimopoulos et al (Dimopoulos et al, 2006). Images were acquired on a 3-Tesla Magnetron Veiro System (Siemens AG, Healthcare Sector, Erlangen, Germany) with pelvic surface coils with patient in supine position.…”

Section: Mri At Brachytherapymentioning

confidence: 99%

Vaginal Dose, Toxicity and Sexual Outcomes in Patients of Cervical Cancer Undergoing Image Based Brachytherapy

Rai

Dhanireddy²,

Patel³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: The aim of the study was to evaluate the vaginal dose and toxicity in patients of cervical cancer treated with image guided brachytherapy at our institute. Materials and Methods: Thirty-five patients treated with image based brachytherapy for cervical cancer were included. Vaginal contouring was done on MRI at brachytherapy and with CT scans of subsequent brachytherapy fractions. Dose volume parameters (DVH) were reported in accordance with the GEC-ESTRO guidelines. These were correlated with vaginal toxicity (assessed by CTCAE version 3) and quality of sexual life assessed at one year of completion of treatment. Results: Vaginal shortness was observed in 22 out of 30 (62.8%) patients, Nine (25.7%) had vaginal dryness and in 10 (28.5%) patients, there was contact bleeding. No association could be demonstrated between the dose volume parameters and vaginal toxicity in the present study. Conclusions: The lack of association between dose volume parameters of vagina with vaginal morbidity may be due to uncertainties involved in the delineation of vaginal wall and dosimetry. Future research is required to accurately define vaginal dose distribution to study its correlation with vaginal morbidity. Vaginal morbidity needs to be documented in order to improve the sexual outcome in these patients.

show abstract

Systematic evaluation of MRI findings in different stages of treatment of cervical cancer: Potential of MRI on delineation of target, pathoanatomic structures, and organs at risk

Cited by 115 publications

References 28 publications

MRI Assessment of Cervical Cancer for Adaptive Radiotherapy

MRI Assessment of Cervical Cancer for Adaptive Radiotherapy

MRI-based pre-planning in patients with cervical cancer treated with three-dimensional brachytherapy

Vaginal Dose, Toxicity and Sexual Outcomes in Patients of Cervical Cancer Undergoing Image Based Brachytherapy

Contact Info

Product

Resources

About