Systematic differences in electrochemical reduction of the structurally characterized anti-cancer platinum(IV) complexes [Pt{((p-HC6F4)NCH2)2}-(pyridine)2Cl2], [Pt{((p-HC6F4)NCH2)2}(pyridine)2(OH)2], and [Pt{((p-HC6F4)NCH2)2}(pyridine)2(OH)Cl]

Guo, SiXuan; Mason, Dayna; Turland, Susan A; Lawrenz, E T; Kelly, Lance; Fallon, Gary D.; Gatehouse, B. M.; Bond, Alan M.; Deacon, Glen B.; Battle, Andrew R.; Hambley, Trevor W.; Rainone, Silvina; Webster, Lorraine K.; Cullinane, Carleen

doi:10.1016/j.jinorgbio.2012.07.016

Cited by 31 publications

(17 citation statements)

References 60 publications

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“…249,250 A recent report describes the action of PhICl 2 on an organoamide platinum(II) complex in a mixture of acetone and basic water. 307 A mixed trans hydroxo-chlorido platinum(IV) complex is obtained (Scheme 22), 307 consistent with a solvent-assisted mechanism, similar to that observed for oxidations by chlorine and hydrogen peroxide.…”

Section: Synthesis Of Platinum(iv) Anticancer Complexessupporting

confidence: 62%

Synthetic Methods for the Preparation of Platinum Anticancer Complexes

2013

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Section: Synthesis Of Platinum(iv) Anticancer Complexessupporting

confidence: 62%

Synthetic Methods for the Preparation of Platinum Anticancer Complexes

2013

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“…This compound does not have hydrogen substituents on the donor nitrogen atoms (81). The drug already has shown anticancer activity against cisplatin-resistant cell lines and is active in vivo (81,82). Pt-103 has caused nearly complete tumor regression in the ADJ/PC6 mouse tumor model (83).…”

Section: Resultsmentioning

confidence: 99%

Infrared nanospectroscopic mapping of a single metaphase chromosome

Lipiec

Ruggeri

Benadiba

et al. 2019

Nucleic Acids Research

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The integrity of the chromatin structure is essential to every process occurring within eukaryotic nuclei. However, there are no reliable tools to decipher the molecular composition of metaphase chromosomes. Here, we have applied infrared nanospectroscopy (AFM-IR) to demonstrate molecular difference between eu- and heterochromatin and generate infrared maps of single metaphase chromosomes revealing detailed information on their molecular composition, with nanometric lateral spatial resolution. AFM-IR coupled with principal component analysis has confirmed that chromosome areas containing euchromatin and heterochromatin are distinguishable based on differences in the degree of methylation. AFM-IR distribution of eu- and heterochromatin was compared to standard fluorescent staining. We demonstrate the ability of our methodology to locate spatially the presence of anticancer drug sites in metaphase chromosomes and cellular nuclei. We show that the anticancer 'rule breaker' platinum compound [Pt[N(p-HC6F4)CH2]2py2] preferentially binds to heterochromatin, forming localized discrete foci due to condensation of DNA interacting with the drug. Given the importance of DNA methylation in the development of nearly all types of cancer, there is potential for infrared nanospectroscopy to be used to detect gene expression/suppression sites in the whole genome and to become an early screening tool for malignancy.

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“…36 In only a few reports have we and others used iodobenzene dichloride in the preparation of platinum anticancer agents bearing axial trans chlorides. 11,37-40 …”

Section: Resultsmentioning

confidence: 99%

Oxidative halogenation of cisplatin and carboplatin: synthesis, spectroscopy, and crystal and molecular structures of Pt(iv) prodrugs

et al. 2015

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A series of Pt(IV) prodrugs has been obtained by oxidative halogenation of either cisplatin or carboplatin. Iodobenzene dichloride is a general reagent that cleanly provides prodrugs bearing axial chlorides without the need to prepare intervening Pt(IV) intermediates or handle chlorine gas. Elemental bromine and iodine afford Pt(IV) compounds as well, although in the case of the iodine-mediated oxidation of carboplatin, an amido-bridged Pt(IV) side product also formed. A detailed analysis of the changes in spectroscopic and structural parameters induced by varying the axial halide is presented. A number of recurring motifs are observed in the solid state structures of these compounds.

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Systematic differences in electrochemical reduction of the structurally characterized anti-cancer platinum(IV) complexes [Pt{((p-HC6F4)NCH2)2}-(pyridine)2Cl2], [Pt{((p-HC6F4)NCH2)2}(pyridine)2(OH)2], and [Pt{((p-HC6F4)NCH2)2}(pyridine)2(OH)Cl]

Cited by 31 publications

References 60 publications

Synthetic Methods for the Preparation of Platinum Anticancer Complexes

Synthetic Methods for the Preparation of Platinum Anticancer Complexes

Infrared nanospectroscopic mapping of a single metaphase chromosome

Oxidative halogenation of cisplatin and carboplatin: synthesis, spectroscopy, and crystal and molecular structures of Pt(iv) prodrugs

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