Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish

Truong, Lisa; Rericha, Yvonne; Thunga, Preethi; Marvel, Skylar W.; Wallis, Dylan J.; Simonich, Michael T.; Field, Jennifer A.; Cao, Dunping; Reif, David M.; Tanguay, Robyn L

doi:10.1016/j.jhazmat.2022.128615

Cited by 38 publications

(25 citation statements)

References 46 publications

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“…PFOSA was the only structure that was bioactive in embryonic photomotor response (EPR), larval photomotor response (LPR), and altered morphology assays (Truong et al, 2022). Compared with PFOA and other commonly seen PFASs, perfluorooctane sulfonamide (PFOSA) was a more potent developmental toxicant because the pathways related to hepatotoxicity and lipid transport were disrupted in embryos, there was a decrease in the liver area and an increase in yolk sac neutral lipids (0.75-128 h post-fertilization/ hpf) (Dasgupta et al, 2020).…”

Section: Pfosamentioning

confidence: 99%

Toxicity of per- and polyfluoroalkyl substances to aquatic vertebrates

Wang

et al. 2023

Front. Environ. Sci.

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Rapid industrial development and extensive use of chemicals have resulted in elevated concentrations of emerging contaminants worldwide, posing a substantial threat to the ecological environment and human health. Per- and polyfluoroalkyl substances (PFASs) have been recognized as emerging pollutants that are widely distributed and accumulated in the environment and they have drawn the attention of scholars for several decades. The variety, long-term use, and long-distance transmission of PFASs have resulted in the ubiquitous contamination of global ecosystems, especially in aquatic environments. Ever since perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) were added to the Stockholm Convention on Persistent Organic Pollutants (POPs), they have become the most typical, eye-catching, and frequently investigated PFASs. Owing to the high stability and bioaccumulation of PFASs, as well as the adverse impact on the endocrine, immune, and nervous systems, investigating their contamination levels, risk of transfer along the food chain, and ecotoxicity should be prioritized. In addition to the important evolutionary significance as primitive vertebrates and the main consumers of aquatic environment, fishes generally exist in various aquatic food chains from the bottom to the top and occupy a critical position in terms of aquatic ecology protection; while amphibians, as the key link from aquatic to terrestrial organisms, are highly sensitive to different environmental pollutants. This review is a comprehensive summary of the toxic effects and toxicity-related factors of PFASs on aquatic vertebrates, mainly Pisces and Amphilla organisms, the characteristics of different aquatic vertebrates in toxicity investigations, and the evaluation of the feasibility of PFASs substitute applications.

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Section: Pfosamentioning

confidence: 99%

Toxicity of per- and polyfluoroalkyl substances to aquatic vertebrates

Wang

et al. 2023

Front. Environ. Sci.

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“…The study showed that 49 PFAS exhibited bioactivity in one or more assays, with 25 induced altered LPR, 11 altered EPR, and 31 altered morphologies. Perfluorooctanesulfonamide (FOSA) was the only substance with activity in the 3 assays and perfluorodecanoic acid (PFDA) was the one that showed the highest bioactivity (Truong et al, 2022).…”

Section: Environment and Health Effectsmentioning

confidence: 99%

Detection and Tertiary Treatment Technologies of Poly-and Perfluoroalkyl Substances in Wastewater Treatment Plants

Araújo

Rodríguez-Hernández

González-González

et al. 2022

Front. Environ. Sci.

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PFAS are a very diverse group of anthropogenic chemicals used in various consumer and industrial products. The properties that characterize are their low degradability as well as their resistance to water, oil and heat. This results in their high persistence in the environment and bioaccumulation in different organisms, causing many adverse effects on the environment as well as in human health. Some of their effects remain unknown to this day. As there are thousands of registered PFAS, it is difficult to apply traditional technologies for an efficient removal and detection for all. This has made it difficult for wastewater treatment plants to remove or degrade PFAS before discharging the effluents into the environment. Also, monitoring these contaminants depends mostly on chromatography-based methods, which require expensive equipment and consumables, making it difficult to detect PFAS in the environment. The detection of PFAS in the environment, and the development of technologies to be implemented in tertiary treatment of wastewater treatment plants are topics of high concern. This study focuses on analyzing and discussing the mechanisms of occurrence, migration, transformation, and fate of PFAS in the environment, as well the main adverse effects in the environment and human health. The following work reviews the recent advances in the development of PFAS detection technologies (biosensors, electrochemical sensors, microfluidic devices), and removal/degradation methods (electrochemical degradation, enzymatic transformation, advanced oxidation, photocatalytic degradation). Understanding the risks to public health and identifying the routes of production, transportation, exposure to PFAS is extremely important to implement regulations for the detection and removal of PFAS in wastewater and the environment.

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“…Zebrafish larvae were screened for 2 morphological endpoints at 24 hpf, 10 morphological endpoints 120 hpf, and mortality at both time points. Dead and individuals with abnormal morphology in any of those endpoints were removed from behavioral analysis [18]. At 120 hpf, individuals were subject to the larval photomotor assay (LPR) using Zebrabox behavioral analysis chambers (ViewPoint Behavior Technologies).…”

Section: Morbidity and Behavioral Assessmentmentioning

confidence: 99%

Utilizing a Population-Genetic Framework to Test for Gene-Environment Interactions between Zebrafish Behavior and Chemical Exposure

Thunga

Truong

Rericha

et al. 2022

Toxics

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Individuals within genetically diverse populations display broad susceptibility differences upon chemical exposures. Understanding the role of gene-environment interactions (GxE) in differential susceptibility to an expanding exposome is key to protecting public health. However, a chemical’s potential to elicit GxE is often not considered during risk assessment. Previously, we’ve leveraged high-throughput zebrafish (Danio rerio) morphology screening data to reveal patterns of potential GxE effects. Here, using a population genetics framework, we apportioned variation in larval behavior and gene expression in three different PFHxA environments via mixed-effect modeling to assess significance of GxE term. We estimated the intraclass correlation (ICC) between full siblings from different families using one-way random-effects model. We found a significant GxE effect upon PFHxA exposure in larval behavior, and the ICC of behavioral responses in the PFHxA exposed population at the lower concentration was 43.7%, while that of the control population was 14.6%. Considering global gene expression data, a total of 3746 genes showed statistically significant GxE. By showing evidence that heritable genetics are directly affecting gene expression and behavioral susceptibility of individuals to PFHxA exposure, we demonstrate how standing genetic variation in a heterogeneous population such as ours can be leveraged to test for potential GxE.

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Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish

Cited by 38 publications

References 46 publications

Toxicity of per- and polyfluoroalkyl substances to aquatic vertebrates

Toxicity of per- and polyfluoroalkyl substances to aquatic vertebrates

Detection and Tertiary Treatment Technologies of Poly-and Perfluoroalkyl Substances in Wastewater Treatment Plants

Utilizing a Population-Genetic Framework to Test for Gene-Environment Interactions between Zebrafish Behavior and Chemical Exposure

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