Systematic design of cell membrane coating to improve tumor targeting of nanoparticles

Liu, Lizhi; Pan, Dingyi; Chen, Sheng; Martikainen, Maria-Viola; Kårlund, Anna; Jin, Ke; Pulkkinen, Herkko; Ruhanen, Hanna; Roponen, Marjut; Käkelä, Reijo; Xu, Wujun; Wang, Jie; Lehto, Vesa‐Pekka

doi:10.1038/s41467-022-33889-3

Cited by 43 publications

(37 citation statements)

References 61 publications

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“…However, this cellular heterogeneity could fine-tune host-pathogen interactions which is challenging to reproduce with our platform. Recent advances on coating beads with native cellular membranes would be an opportunity to recreate this complexity ( 20, 21 ). Another limitation of fBSLBs is its inability to initially detect cellular toxic compounds.…”

Section: Discussionmentioning

confidence: 99%

A Multiparametric and High-Throughput Platform for Host-Virus Binding Screens

Schlegel

Porębski

Andronico

et al. 2022

Preprint

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Speed is key during infectious disease outbreaks. It is essential, for example, to identify critical host binding factors to the pathogens as fast as possible. The complexity of host plasma membrane is often a limiting factor hindering fast and accurate determination of host binding factors as well as high-throughput screening for neutralizing antimicrobial drug targets. Here we describe MIGH-T, a multi-parametric and high-throughput platform tackling this bottleneck and enabling fast screens for host binding factors as well as new antiviral drug targets. The sensitivity and robustness of our platform was validated by blocking SARS-CoV-2 spike particles with nanobodies and IgGs from human serum samples.

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Section: Discussionmentioning

confidence: 99%

A Multiparametric and High-Throughput Platform for Host-Virus Binding Screens

Schlegel

Porębski

Andronico

et al. 2022

Preprint

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“…With the mentioned approach, the rate of NPs with full coating reaches 23% which is significantly higher than previously-designed full coating approaches (6%). Moreover, full coated-NPs achieved by this technique showed a significant better tumor targeting and accumulation properties ( Liu et al, 2022c ).…”

Section: An Overview On Cm-coating Technologymentioning

confidence: 99%

The role of cell membrane-coated nanoparticles as a novel treatment approach in glioblastoma

Allami

Heidari²,

Rezaei³

2023

Front. Mol. Biosci.

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Glioblastoma multiform (GBM) is the most prevalent and deadliest primary brain malignancy in adults, whose median survival rate does not exceed 15 months after diagnosis. The conventional treatment of GBM, including maximal safe surgery followed by chemotherapy and radiotherapy, usually cannot lead to notable improvements in the disease prognosis and the tumor always recurs. Many GBM characteristics make its treatment challenging. The most important ones are the impermeability of the blood-brain barrier (BBB), preventing chemotherapeutic drugs from reaching in adequate amounts to the tumor site, intratumoral heterogeneity, and roles of glioblastoma stem cells (GSCs). To overcome these barriers, the recently-developed drug-carrying approach using nanoparticles (NPs) may play a significant role. NPs are tiny particles, usually less than 100 nm showing various diagnostic and therapeutic medical applications. In this regard, cell membrane (CM)-coated NPs demonstrated several promising effects in GBM in pre-clinical studies. They benefit from fewer adverse effects due to their specific targeting of tumor cells, biocompatibility because of their CM surfaces, prolonged half-life, easy penetrating of the BBB, and escaping from the immune reaction, making them an attractive option for GBM treatment. To date, CM-coated NPs have been applied to enhance the effectiveness of major therapeutic approaches in GBM treatment, including chemotherapy, immunotherapy, gene therapy, and photo-based therapies. Despite the promising results in pre-clinical studies regarding the effectiveness of CM-coated NPs in GBM, significant barriers like high expenses, complex preparation processes, and unknown long-term effects still hinder its mass production for the clinic. In this regard, the current study aims to provide an overview of different characteristics of CM-coated NPs and comprehensively investigate their application as a novel treatment approach in GBM.

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“…21,22 With specific coating lipids, these NPs demonstrate excellent targeting abilities for membranes and even tissues, showing great potential in precision medicine. [23][24][25][26][27][28] However, given the intricate nature of biological processes and the growing need to expand the potential biomedical applications of NPs, further efforts are required to develop novel regulatory strategies for NP cellular uptake, such as exploring new NP species or properties and investigating alternative modes of membrane-NP interactions. [29][30][31][32][33][34][35] Photothermal therapy (PTT) has garnered significant attention in recent years as a promising noninvasive technique for tumor treatment.…”

Section: Introductionmentioning

confidence: 99%