Systematic characterization of the local evolutionary space available to human PKR and vaccinia virus K3
Michael J. Chambers,
Sophia Scobell,
Meru J. Sadhu
Abstract:The interfaces between host and viral proteins can be dynamic spaces in which genetic variants are continually pursued, giving rise to evolutionary arms races. One such scenario is found between the mammalian innate immunity protein PKR (protein kinase R) and the poxvirus antagonist K3. Once activated, PKR phosphorylates the natural substrate eIF2α, which halts protein synthesis within the cell and prevents viral replication. K3 acts as a pseudosubstrate antagonist against PKR by directly antagonizing this hal… Show more
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