Systematic characterisation of the structure and radical scavenging potency of Pu'Er tea () polyphenol theaflavin

Vu, Huyen Trang; Song, Fu; Tian, Kun; Su, Haibin; Chass, Gregory A.

doi:10.1039/c9ob02007a

Cited by 15 publications

(14 citation statements)

References 45 publications

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“…Like EGCG, theaflavins can stimulate Aβ and α nuclide (αS) to assemble non-toxic spherical polymers, and are effective inhibitors of Aβ and αS fiber formation. Mechanism studies have shown that theaflavins have a stronger conjugation effect and phenol-qhinone balance structure than catechins, leading to stronger proton supply and nucleophilicity, which is essential to inhibit the aggregation of Aβ [65][66][67][68][69][70].…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Six Types of Tea on Aging and High-Fat Diet-Related Amyloid Formation Activities

et al. 2021

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Aging and lipid metabolism disorders promote the formation and accumulation of amyloid with β-sheet structure, closely related to cardiovascular disease, senile dementia, type 2 diabetes, and other senile degenerative diseases. In this study, five representative teas were selected from each of the six types of tea, and a total of 30 teas were selected to evaluate the inhibitory activities on the formation of aging-related amyloid in vitro. The results showed that the 30 teas had a significant inhibitory effect on the formation activity on aging-related amyloid at the protein level in vitro. Although the content of catechins is relatively low, black tea and dark tea still have significant antioxidant activity and inhibit the formation of amyloid. A high-fat diet established the model of lipid metabolism disorder in premature aging SAMP8 mice, and these mice were gavaged different tea water extracts. The results showed that different tea types have a significant inhibitory effect on the formation of β-amyloid and Aβ42 mediated by age-related lipid metabolism disorders, and the in vivo activity of fully fermented teas was better than that of green tea. The action mechanism was related to antioxidation, anti-inflammatory, and improving lipid metabolism.

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Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Six Types of Tea on Aging and High-Fat Diet-Related Amyloid Formation Activities

et al. 2021

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“…33 A systematic approach of indexing and accounting for the contributions of each molecular component and their individual degrees of freedom allows one to more effectively generate a non-degenerate set of topologically possible conformations ( poses) towards resolving the structurally probable set. Such an approach has been successfully implemented for peptides, 34 lipids, 35,36 anti-oxidants, 37,38 bioactive molecules, [39][40][41][42] antibiotics 43 and relevant polyphenols. 44 Each manifests their own unique set of conformational poses, stabilised by unique intramolecular interactions 45 and systemic energy management.…”

Section: Papermentioning

confidence: 99%

Bioactivity of the cannabigerol cannabinoid and its analogues – the role of 3-dimensional conformation

et al. 2023

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“…The strong antioxidant activity of theaflavins gives them unique physiological functions. The diversity of the theaflavin structure is mainly caused by the changes in its 9-OH group, and its structural preference is regulated by its unique fused bicyclic benzotropolone part and its flatness . It can be seen from Figure that the benzophenone ring structure formed by the two B rings may be the preferred oxidation position of TF.…”

Section: Physicochemical Properties and Biosynthesis Of Theaflavinsmentioning

confidence: 99%

“…The diversity of the theaflavin structure is mainly caused by the changes in its 9-OH group, and its structural preference is regulated by its unique fused bicyclic benzotropolone part and its flatness. 67 It can be seen from Figure 1 that the benzophenone ring structure formed by the two B rings may be the preferred oxidation position of TF. They are considered to be the basis of theaflavin's superior ability to scavenge free radicals and neutralize reactive oxygen species (ROS).…”

Section: ■ Introductionmentioning

confidence: 99%

Anticancer Effects and Molecular Target of Theaflavins from Black Tea Fermentation in Vitro and in Vivo

Luo

Jiang

2021

J. Agric. Food Chem.

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Black tea is one of the most popular beverages in the world, and numerous epidemiological studies have shown that drinking black tea is good for health. As a natural tea pigment formed during the fermentation of black tea, the content of theaflavins accounts for only 2−6% of the dry weight of black tea, but they have a great impact on the color and taste of black tea soup. Recently, a large number of studies have shown that theaflavins have a significant anticancer effect. In this Perspective, we first state the physical and chemical properties, separation and purification methods, and biological formation pathways of theaflavins and analyze their safety and oral bioavailability and the structure−activity relationship of their antioxidant and anticancer activities; then, we describe in detail their anticancer effect in vitro and in vivo and highlight their various molecular targets involved in cancer inhibition. The anticancer molecular targets of theaflavins are mainly cell-cycle regulatory proteins, apoptosis-related proteins, cellmigration-related proteins, and growth transcription factors. Finally, the possibility of developing new health-care food based on theaflavins is discussed. This Perspective is expected to provide a theoretical basis for the anticancer application of theaflavins in the future.

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Systematic characterisation of the structure and radical scavenging potency of Pu'Er tea () polyphenol theaflavin

Abstract: Resolving the functional 3D structural poses of Pu'Er tea antioxidant theaflavin.

Cited by 15 publications

References 45 publications

Inhibitory Effects of Six Types of Tea on Aging and High-Fat Diet-Related Amyloid Formation Activities

Inhibitory Effects of Six Types of Tea on Aging and High-Fat Diet-Related Amyloid Formation Activities

Bioactivity of the cannabigerol cannabinoid and its analogues – the role of 3-dimensional conformation

Anticancer Effects and Molecular Target of Theaflavins from Black Tea Fermentation in Vitro and in Vivo

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