Systematic Cancer-Testis Expression Analysis Identifies CDCA5 As a Potential Therapeutic Target in Esophageal Squamous Cell Carcinoma

Xu, Jianping; Zhu, Chengxiang; Yu, Yue; Wu, Weibing; Cao, Jing; Li, Zhihua; Dai, Juncheng; Wang, Cheng; Tang, Yu; Zhu, Quan; Wang, Jun; Wei, Wen Jun; Xue, Lijun; Zhen, Fuxi; Liu, Jinyuan; Huang, Chenjun; Zhao, Fei; Zhou, Yue; He, Zhicheng; Pan, Xinliang; Wei, Haixing; Zhu, Yining; He, Yunjie; Que, Jun; Luo, Jiwei; Liang, Changhong; Wang, Wei

doi:10.2139/ssrn.3343635

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“…HAT1 has been observed to trigger cisplatin resistance and stimulate the hepatocellular carcinoma cell proliferation (Jin, Tian, & Li, ). Existing evidence supports the functionality of HAT1 as a promising target of drug for esophageal squamous cell cancer treatment (Xue et al, ; Yang et al, ). HAT1 exercises its carcinogenic properties in various human cancers.…”

Section: Resultsmentioning

confidence: 78%

“…The microRNA‐377 (miR‐377) has been demonstrated to significantly influence many kinds of cancers, for example, OS, renal carcinoma, glioblastoma, and malignant melanoma (Chang et al, ). The impact of histone acetyltransferases (HATs) has been trivial on various cellular processes through acetylation and deacetylation with their dysfunction greatly affecting carcinogenesis by modulating the respective genes associated with cell apoptosis and proliferation; thus their inhibitors may represent a desirable therapeutic tool (Xue et al, ). Histone acetyltransferase 1 (HAT1), the first identified HAT, was originally discovered in yeast and showed diverse functionality on cells in varied distribution patterns (Lebel, Boukamp, & Tafrov, ).…”

Section: Introductionmentioning

confidence: 99%

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MicroRNA‐377 exerts a potent suppressive role in osteosarcoma through the involvement of the histone acetyltransferase 1‐mediated Wnt axis

Xia

Zhang

et al. 2019

Journal Cellular Physiology

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It has been demonstrated that microRNAs (miRNAs) may contribute to tumorigenesis and tumor growth in osteosarcoma (OS), which is a primary malignant tumor of bone frequently diagnosed in adolescents and young people. The purpose of our investigation was to evaluate the functional relevance of miR-377 in OS and to investigate whether the mechanism was related to the histone acetyltransferase 1 (HAT1)-mediated Wnt signaling pathway. By screening differentially expressed genes in microarray GSE47572, HAT1 was found to be a candidate gene of interest. Besides, the regulatory miRNA (miR-377) of HAT1 was also selected. The interaction among miR-377, HAT1, and the Wnt signaling pathway was evaluated. In addition, the miR-377 expression was altered in OS cells (U-2OS and SOSP-9607) to assess the in vitro cell apoptosis and the in vivo tumor growth. OS tissues presented elevated HAT1 expression and decreased miR-377 expression. A putative miR-377 binding site in HAT1 3′-UTR HAT1 was verified. Cells with miR-377 overexpression or HAT1 silencing were observed to exhibit reduced HAT1 expression and promoted apoptosis, accompanied by blockade of Wnt signaling. Moreover, the in vivo experiment revealed that miR-377 overexpression or HAT1 silencing inhibited tumor growth and reduced tumor size in nude mice. Taken together, our results conclude that miR-377 may promote OS cell apoptosis through inactivation of the HAT1mediated Wnt signaling pathway, highlighting the potential therapeutic effect of miR-377 on OS treatment.

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Section: Resultsmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%