In recent years, interest has increased in biorefineries that use a variety of biomass residues and non‐food crops. Triticale (X Triticosecale Wittmack) is a human‐developed crop that has the potential to become a preferred industrial energy crop for the biorefinery because of its capacity to grow on marginal land, its higher yields compared to existing cereal crops such as wheat, and its non‐competition with food‐based crops. However, implementation of the triticale‐based biorefinery will require the identification of sustainable strategies and as its sustainability pillar, the identification of economically promising strategies. In this study, the economic performance of several triticale‐based product‐process scenarios, including the production of ethanol, polylactic acid (PLA), and thermoplastic starch polymer, has been assessed through the evaluation of six economic criteria. These conflicting criteria have been evaluated in a multi‐criteria decision‐making (MCDM) panel, demonstrated for PLA platform, which has made it possible (i) to rank the alternatives by their economic performance, and (ii) to identify a set of the most important criteria to be used in a sustainability study. The MCDM results show that the alternatives with the best performance on profitability‐oriented criteria do not necessarily achieve the highest overall economic score. This suggests the need to consider both business‐strategy‐oriented criteria and profitability‐oriented criteria in strategic decision‐making. The MCDM results show that the internal rate of return, the downside internal rate of return, and the resistance to supply market uncertainty with relative weights of 24.8%, 23.6%, and 18.1% respectively, are the most important of the criteria assessed. © 2018 Society of Chemical Industry and John Wiley & Sons, Ltd