Systematic approaches for biodiagnostics using exhaled air

Shende, Pravin; Vaidya, Jai; Kulkarni, Yogesh A.; Gaud, Ram

doi:10.1016/j.jconrel.2017.10.035

Cited by 37 publications

(17 citation statements)

References 112 publications

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“…Furthermore, selected ion flow tube-mass spectrometry (SIFT-MS), allows one to quantify a range of VOCs in air and breath in a single test. This technique is based on the principle of chemical ionization (63) and potentially allows for a fast assessment of occupational exposure in real time (64,65). The main limitation is the uncertain quantification and identification of analyte ions, and the fact that it is expensive and spaceconsuming (63,65).…”

Section: Breath Analysis: Methodsmentioning

confidence: 99%

“…This technique is based on the principle of chemical ionization (63) and potentially allows for a fast assessment of occupational exposure in real time (64,65). The main limitation is the uncertain quantification and identification of analyte ions, and the fact that it is expensive and spaceconsuming (63,65). Lastly, proton transfer reaction-mass spectrometry (PTR-MS) is also based on the principal of chemical ionization whereby analytes are characterized according to mass/charge ratio.…”

Section: Breath Analysis: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Breath analysis as a diagnostic and screening tool for malignant pleural mesothelioma: a systematic review

Brusselmans

Arnouts

Millevert

et al. 2018

Transl. Lung Cancer Res

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Malignant pleural mesothelioma (MPM) is a tumour related to a historical exposure to asbestos fibres. Currently, the definite diagnosis is made only by the histological examination of a biopsy obtained through an invasive thoracoscopy. However, diagnosis is made too late for curative treatment because of non-specific symptoms mainly appearing at advanced stage disease. Hence, due to its biologic aggressiveness and the late diagnosis, survival rate is low and the patients' outcome poor. In addition, radiological imaging, like computed tomographic scans, and blood biomarkers are found not to be sensitive enough to be used as an early diagnostic tool. Detection in an early stage is assumed to improve the patients' outcome but is hampered due to non-specific and late symptomology. Hence, there is a need for a new screening and diagnostic test which could improve the patients' outcome. Despite extensive research has focused on blood biomarkers, not a single has been shown clinically useful, and therefore research recently shifted to "breathomics" techniques to recognize specific volatile organic compounds (VOCs) in the breath of the patient as potential non-invasive biomarkers for disease. In this review, we summarize the acquired knowledge about using breath analysis for diagnosing and monitoring MPM and asbestos-related disorders (ARD). Gas chromatography-mass spectrometry (GC-MS), the gold standard of breath analysis, appears to be the method with the highest accuracy (97%) to differentiate MPM patients from at risk asbestosexposed subjects. There have already been found some interesting biomarkers that are significantly elevated in asbestosis (NO, 8-isoprostane, leukotriene B4, α-Pinene…) and MPM (cyclohexane) patients. Regrettably, the different techniques and the plethora of studies suffer some limitations. Most studies are pilot studies with the inclusion of a limited number of patients. Nevertheless, given the promising results and easy sampling methods, we can conclude that breath analysis may become a useful tool in the future to screen for MPM, but further research is warranted.

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Section: Breath Analysis: Methodsmentioning

confidence: 99%

Section: Breath Analysis: Methodsmentioning

confidence: 99%

Breath analysis as a diagnostic and screening tool for malignant pleural mesothelioma: a systematic review

Brusselmans

Arnouts

Millevert

et al. 2018

Transl. Lung Cancer Res

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“…Modifications of surface characteristics, polymer biocompatibility and better drug loading capacity of nanocarriers provide the advantages of biosensors [ 42–45 ] in comparison with other implants. In case of nano‐biosensors, multifunctional in‐vivo therapies such as self‐powered triboelectric nanogenerators released the drug at the targeted site in response to the seizure attack.…”

Section: Nanotheranostic Strategies In Epilepsymentioning

confidence: 99%

Nanotheranostics in epilepsy: A perspective for multimodal diagnosis and strategic management

Shende

Trivedi

2021

Nano Select

Self Cite

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Epilepsy is a common but a complex neurological disorder with limited practices for successful management due to the complicated neuronal network and lack of knowledge of epileptic pathophysiology. Theranostic systems such as implantable devices and biodegradable nanomaterials offer better tailor‐made methods for the detection and treatment using nanotechnology‐based approaches for patients with epilepsy. Miniaturized nano‐implantable devices and biosensors equipped with operations to mimic neurostimulation demonstrate excellent opportunities in profiling the disease and assist in comprehension of the relationship between the disease and host. This strategy is developed for diagnoses and mapping brain activities to integrate and target therapeutic nanosystems in epilepsy. Non‐invasive class of nanotheranostics such as biodegradable and stimuli‐responsive polymers includes nanomaterials that utilize bio‐physico‐chemical processes or stimuli as a source for detecting the state and progress of the disease. The superior form of nanotheranostics encompasses in‐situ diagnostics with triggered release at the specific site. This review article focuses on the nanotheranostic strategies for epilepsy, their implications, challenges and new potentials for detection and therapy in personalized medicine. The concept of “on‐demand” release of drugs at the site of action using bio‐responsive theranostic approach reveals a potential for developing a point of primary care for epilepsy in the future.

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“…SIFT-MS is better for complex mixtures of unknown composition but has low detection selectivity and requires frequent calibrations [28,29]. Both are used in various from both natural and anthropogenic atmospheric chemistry [30,31], plant studies [32], food science [33], and medical applications like breath-analysis [34][35][36]. GC-MS can analyze multiple compounds simultaneously with detection-sensitivity of ppb (parts-per-billion) to ppt (parts-per-trillion) but requires complicated procedures for sample collection and pre-concentration and also has high instrument costs [37][38][39].…”

Section: Introductionmentioning

confidence: 99%

Applications of Near Infrared Photoacoustic Spectroscopy for Analysis of Human Respiration: A Review

et al. 2020

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In this review, applications of near-infrared photoacoustic spectroscopy are presented as an opportunity to evaluate human respiration because the measurement of breath is fast, intact and simple to implement. Recently, analytical methods for measuring biomarkers in exhaled air have been extensively developed. With laser-based photoacoustic spectroscopy, volatile organic compounds can be identified with high sensitivity, at a high rate, and with very good selectivity. The literature review has shown the applicability of near-infrared photoacoustic spectroscopy to one of the problems of the real world, i.e., human health. In addition, the review will consider and explore different breath sampling methods for human respiration analysis.

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Systematic approaches for biodiagnostics using exhaled air

Cited by 37 publications

References 112 publications

Breath analysis as a diagnostic and screening tool for malignant pleural mesothelioma: a systematic review

Breath analysis as a diagnostic and screening tool for malignant pleural mesothelioma: a systematic review

Nanotheranostics in epilepsy: A perspective for multimodal diagnosis and strategic management

Applications of Near Infrared Photoacoustic Spectroscopy for Analysis of Human Respiration: A Review

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