Systematic approach for assessment of imaging features in chronic pancreatitis: a feasibility and validation study from the Scandinavian Baltic Pancreatic Club (SBPC) database

Lisitskaya, M. V.; Olesen, Søren Schou; Svarc, Petra; Ebrahim, Mohamed A.; Jensen, Annette Bøjer; Nøjgaard, Camilla; Nørregaard, Peter; Drewes, Asbjørn Mohr; Haldorsen, Ingfrid Salvesen; Engjom, Trond; Frøkjær, Jens Brøndum

doi:10.1007/s00261-020-02466-x

Cited by 12 publications

(10 citation statements)

References 29 publications

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“…We performed measurements using the same standardized positions for the pancreatic body, and added a standardized measurement of the pancreatic head. These standards are simple and have demonstrated good inter-observer reproducibility [17]. The 25-percentile cut-off for the measures of the body of pancreas in males in our cohort was largely corresponding to the cut-offs for moderate atrophy in the two studies mentioned above, but indicate a somewhat lower cut-off for females.…”

Section: Discussionsupporting

confidence: 60%

“…By distributing instructions to the centres before the registrations, we attempted to reduce such differences. In a recent study we found good inter-observer reproducibility for the applied standards [17].…”

Section: Limitationsmentioning

confidence: 71%

“…Radiologists or clinicians with special experience in pancreatic imaging reviewed the imaging studies at each centre. Standardized definitions and instructions for reporting assessments into the imaging module of the SBPC database were provided [17]. Definitions are presented in Table 1.…”

Section: Pancreatic Imaging Datamentioning

confidence: 99%

“…Some continuous variables such as number of calcifications and two-dimensional measurements of pancreatic size and ductal diameter are also included. The inter-observer agreement for imaging features in the SBPC imaging module was recently published [17].…”

Section: Introductionmentioning

confidence: 99%

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Aetiological risk factors are associated with distinct imaging findings in patients with chronic pancreatitis: A study of 959 cases from the Scandinavian Baltic Pancreatic Club (SBPC) imaging database

et al. 2021

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Section: Discussionsupporting

confidence: 60%

Section: Limitationsmentioning

confidence: 71%

Section: Pancreatic Imaging Datamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Aetiological risk factors are associated with distinct imaging findings in patients with chronic pancreatitis: A study of 959 cases from the Scandinavian Baltic Pancreatic Club (SBPC) imaging database

et al. 2021

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“…Both followed standards for reading that were defined in advance. 18 They were blinded to other examiner's interpretation of the imaging data and results from other diagnostic tests. Blinding for the general reason for referral (suspected CP) was not feasible.…”

Section: Image Analysismentioning

confidence: 99%

Diagnostic Accuracy of Computed Tomography Scores in Chronic Pancreatitis

et al. 2021

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Objectives: Computed tomography (CT) is the most commonly used imaging modality when diagnosing chronic pancreatitis (CP). We aimed to evaluate the diagnostic accuracy of CT scores for diagnosing CP.Methods: One hundred eighteen patients were retrospectively included from an observational cohort study that comprised patients referred because of suspected CP. Patients were categorized as CP or non-CP using a modified Mayo score based on biochemistry, clinical presentation, and findings on endoscopic ultrasound and/or transabdominal ultrasound. The CT scans were scored according to the modified Cambridge classification and the unweighted CT score. Diagnostic performance indices were calculated using the modified Mayo score as reference standard.Results: Seventy-six of the 118 patients fulfilled the CP diagnostic criteria (Mayo score ≥4). The modified Cambridge classification and the unweighted CT score yielded sensitivities of 63% and 67% and specificities of 91% and 91%, respectively, and similar areas under the receiver operating characteristic curves (95% confidence interval) of 0.79 (0.71-0.88)/0.81 (0.73-0.89), respectively (P, not significant).Conclusions: Both CT scores had similar, moderate accuracies for diagnosing CP. The limitation in diagnostic accuracy makes CT ineligible as a single method to diagnose CP, supporting that the diagnostic process for CP needs to incorporate other imaging methods and/or markers for better diagnostics.

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Structural imaging findings are related to clinical complications in chronic pancreatitis

et al. 2022

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Background/objectives Structural pancreatic changes and complications related to chronic pancreatitis are well described, but little is known about their relationship. We aimed to explore the associations between pancreatic morphology and clinical complications in a large chronic pancreatitis cohort. Methods The Scandinavian Baltic Pancreatic Club database collects registrations on patients with definite or probable chronic pancreatitis according to the M‐ANNHEIM diagnostic criteria. In this cross‐sectional study, we used multivariate logistic regression analyses to evaluate whether imaging‐based structural pancreatic changes were associated with common clinical complications. We adjusted for sex, age, disease duration, current alcohol abuse and current smoking. Results We included 742 patients with a mean age of 55 years. Among these, 68% were males, 69% had pancreatic exocrine insufficiency, 35% had diabetes, 12% were underweighted and 68% reported abdominal pain. Main pancreatic duct obstruction, severe (i.e. more than 14) calcifications, pancreatic atrophy and parenchymal changes throughout the entire pancreas (continuous organ involvement) were positively associated with pancreatic exocrine insufficiency. Continuous organ involvement and pseudocysts were positively and negatively associated with diabetes, respectively. Pancreatic atrophy and severe calcifications were positively associated with underweight, and severe calcifications were negatively associated with pain. Conclusions This study shows independent associations between distinct structural changes on pancreatic imaging and clinical complications in chronic pancreatitis. Pancreatic atrophy, severe calcifications and continuous organ involvement may be of particular clinical relevance, and these findings should motivate monitoring of pancreatic function and nutritional status.

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Systematic approach for assessment of imaging features in chronic pancreatitis: a feasibility and validation study from the Scandinavian Baltic Pancreatic Club (SBPC) database

Cited by 12 publications

References 29 publications

Aetiological risk factors are associated with distinct imaging findings in patients with chronic pancreatitis: A study of 959 cases from the Scandinavian Baltic Pancreatic Club (SBPC) imaging database

Aetiological risk factors are associated with distinct imaging findings in patients with chronic pancreatitis: A study of 959 cases from the Scandinavian Baltic Pancreatic Club (SBPC) imaging database

Diagnostic Accuracy of Computed Tomography Scores in Chronic Pancreatitis

Structural imaging findings are related to clinical complications in chronic pancreatitis

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