Systematic and meta-analysis of Mycobacterium avium subsp. paratuberculosis related type 1 and type 2 diabetes mellitus

Ekundayo, Temitope C.; Falade, Ayodeji O.; Igere, Bright E.; Iwu, Chidozie Declan; Adewoyin, Mary Ayobami; Olasehinde, Tosin A.; Ijabadeniyi, Oluwatosin Ademola

doi:10.1038/s41598-022-08700-4

Cited by 10 publications

(10 citation statements)

References 64 publications

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“…In Canada, the annual economic impact of JD is estimated at $28 million USD, mainly due to reduced milk production, increased cattle mortality, and the early culling of infected animals ( Rasmussen et al, 2021 ). In addition, this infection has raised concerns, in part due to the possible link between MAP and Crohn’s disease in humans, leading to discussions related to the impact of MAP on chronic diseases and food safety ( Waddell L. A. et al, 2016 ; Kuenstner et al, 2017 ; Agrawal et al, 2021 ; Ekundayo et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Genomic epidemiology of Mycobacterium avium subsp. paratuberculosis isolates from Canadian dairy herds provides evidence for multiple infection events

et al. 2023

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Mycobacterium avium subsp. paratuberculosis (MAP) is the pathogen responsible for paratuberculosis or Johne’s Disease (JD) in ruminants, which is responsible for substantial economic losses worldwide. MAP transmission primarily occurs through the fecal-oral route, and the introduction of an MAP infected animal into a herd is an important transmission route. In the current study, we characterized MAP isolates from 67 cows identified in 20 herds from the provinces of Quebec and Ontario, Canada. Whole genome sequencing (WGS) was performed and an average genome coverage (relative to K-10) of ∼14.9 fold was achieved. The total number of SNPs present in each isolate varied from 51 to 132 and differed significantly between herds. Isolates with the highest genetic variability were generally present in herds from Quebec. The isolates were broadly separated into two main clades and this distinction was not influenced by the province from which they originated. Analysis of 8 MIRU-VNTR loci and 11 SSR loci was performed on the 67 isolates from the 20 dairy herds and publicly available references, notably major genetic lineages and six isolates from the province of Newfoundland and Labrador. All 67 field isolates were phylogenetically classified as Type II (C-type) and according to MIRU-VNTR, the predominant type was INMV 2 (76.1%) among four distinct patterns. Multilocus SSR typing identified 49 distinct INMV SSR patterns. The discriminatory index of the multilocus SSR typing was 0.9846, which was much higher than MIRU-VNTR typing (0.3740). Although multilocus SSR analysis provides good discriminatory power, the resolution was not informative enough to determine inter-herd transmission. In select cases, SNP-based analysis was the only approach able to document disease transmission between herds, further validated by animal movement data. The presence of SNPs in several virulence genes, notably for PE, PPE, mce and mmpL, is expected to explain differential antigenic or pathogenetic host responses. SNP-based studies will provide insight into how MAP genetic variation may impact host-pathogen interactions. Our study highlights the informative power of WGS which is now recommended for epidemiological studies and to document mixed genotypes infections.

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Section: Introductionmentioning

confidence: 99%

Genomic epidemiology of Mycobacterium avium subsp. paratuberculosis isolates from Canadian dairy herds provides evidence for multiple infection events

et al. 2023

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“…The statistical program R 4.0.5 packages was used to conduct all analyses with 2-tailed of p -values < 0.05 level of significance [30] . Further, heterogeneity between studies was quantified using Q -statistic and I 2 -statistics at a significant heterogeneity threshold [33] , [34] , [35] .…”

Section: Methods and Search Strategiesmentioning

confidence: 99%

Polymyxin sensitivity/resistance cosmopolitan status, epidemiology and prevalence among O1/O139 and non-O1/non-O139 Vibrio cholerae: A meta-analysis

Igere,

Onohuean,

Iwu

et al. 2023

Infectious Medicine

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“…T1D is a severe autoimmune condition associated with infant exposure to dietary cow milk (Dow & Alvarez, 2022;Ozana et al, 2022), with the disease high in children worldwide (Ozana et al, 2022). An investigation using meta-analysis found that anti-MAP antibodies and MAP deoxyribonucleic acid (DNA) have a significant link with T1D (Ekundayo et al, 2022b). Association between MAP and T1D has been confirmed using polymerase chain reaction (PCR); by detecting MAP-specific IS900 signature (Sechi et al, 2008;Rosu et al, 2009;Rani et al, 2010;Shariati et al, 2016), immune assay (ELISA); by detecting antibodies against MAP 3865c and ZnT8 homologous epitopes, and the detection of the cell envelope protein (MptD) and immune response to MptD peptide.…”

Section: Tablementioning

confidence: 99%

Paratuberculosis Cases in the Livestock Industry in Nigeria: A Review

Gana,

Kuyet,

Abdurrahman

2023

Ukr. Jour. of Vet. and Agr. Sci.

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Paratuberculosis, also known as Johne’s (Yo’-ness) disease, is a significant bacterial disease of large and small ruminants, including other animals, caused by Mycobacterium avium subspecies paratuberculosis (MAP). Due to its impact on animal health and severe economic loss, the disease is recognized and reported in developed countries as a significant disease of livestock importance. The paper aims to review the current information about paratuberculosis in Nigeria. About 95 research articles were downloaded from various online journals databases such as Scopus, Google Scholar, Research Gate, PubMed, and CABI abstracts based on the following keywords: Johne’s disease, paratuberculosis, Africa, prevalence, Nigeria, report, occurrence, and Mycobacterium avium subspecies paratuberculosis. In addition to the perusal of organization databases, 60 research articles were used in writing this review article. Few cases and suspected cases of paraTB were reported in Nigeria by the World Organization for Animal Health (OIE). Despite growing global concerns, Johne's disease can be considered an unreported disease of livestock animals in Nigeria based on the knowledge gap and lack of reports about this significant disease of livestock animals. Studies need to be carried out to address the knowledge gaps before the disease becomes endemic and causes severe economic and public health menace in Nigeria and, by extension, Sub-Saharan Africa.

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Systematic and meta-analysis of Mycobacterium avium subsp. paratuberculosis related type 1 and type 2 diabetes mellitus

Cited by 10 publications

References 64 publications

Genomic epidemiology of Mycobacterium avium subsp. paratuberculosis isolates from Canadian dairy herds provides evidence for multiple infection events

Genomic epidemiology of Mycobacterium avium subsp. paratuberculosis isolates from Canadian dairy herds provides evidence for multiple infection events

Polymyxin sensitivity/resistance cosmopolitan status, epidemiology and prevalence among O1/O139 and non-O1/non-O139 Vibrio cholerae: A meta-analysis

Paratuberculosis Cases in the Livestock Industry in Nigeria: A Review

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